BPG is committed to discovery and dissemination of knowledge
Cited by in CrossRef
For: Chaicharoenaudomrung N, Kunhorm P, Noisa P. Three-dimensional cell culture systems as an in vitro platform for cancer and stem cell modeling. World J Stem Cells 2019; 11(12): 1065-1083 [PMID: 31875869 DOI: 10.4252/wjsc.v11.i12.1065]
URL: https://www.wjgnet.com/1948-0210/full/v11/i12/1065.htm
Number Citing Articles
1
Soliman Alhudaithy, Kazunori Hoshino, Esmaiel Jabbari. Biocompatible micro tweezers for 3D hydrogel organoid array mechanical characterizationPLOS ONE 2022; 17(1) doi: 10.1371/journal.pone.0262950
2
Cristina Banda Sánchez, Nieves Cubo Mateo, Laura Saldaña, Alba Valdivieso, Julie Earl, Itziar González Gómez, Luis M. Rodríguez-Lorenzo. Selection and Optimization of a Bioink Based on PANC-1- Plasma/Alginate/Methylcellulose for Pancreatic Tumour ModellingPolymers 2023; 15(15) doi: 10.3390/polym15153196
3
Sarah Alsobaie, Tamador Alsobaie, Amal F Alshammary, Manal Abudawood, Athanasios Mantalaris. Alginate Beads as a Promising Tool for Successful Production of Viable and Pluripotent Human-Induced Pluripotent Stem Cells in a 3D Culture SystemStem Cells and Cloning: Advances and Applications 2023;  doi: 10.2147/SCCAA.S409139
4
Paramjeet Yadav, Shiwani Singh, Sheetal Jaiswal, Rajesh Kumar. Synthetic and natural polymer hydrogels: A review of 3D spheroids and drug deliveryInternational Journal of Biological Macromolecules 2024; 280 doi: 10.1016/j.ijbiomac.2024.136126
5
Ender Berat ELLİDOKUZ, Tolga SEVER, Gizem ÇALIBAŞI KOÇAL, Aras Emre CANDA, Sulen SARİOGLU, Hasan KURTER, İlhan ÖZTOP, Yeşim TUNÇOK, Yasemin BAŞBINAR. Tissue Processing and Isolation of Tumor Cells from Human Colorectal Cancer TissueJournal of Basic and Clinical Health Sciences 2022; 6(3) doi: 10.30621/jbachs.1154867
6
Jacob G Hodge, Jennifer L Robinson, Adam J Mellott. Novel Hydrogel System Eliminates Subculturing and Improves Retention of Nonsenescent Mesenchymal Stem Cell PopulationsRegenerative Medicine 2023; 18(1) doi: 10.2217/rme-2022-0140
7
Sara Al-Ghadban, India A. Pursell, Zaidmara T. Diaz, Karen L. Herbst, Bruce A. Bunnell. 3D Spheroids Derived from Human Lipedema ASCs Demonstrated Similar Adipogenic Differentiation Potential and ECM Remodeling to Non-Lipedema ASCs In VitroInternational Journal of Molecular Sciences 2020; 21(21) doi: 10.3390/ijms21218350
8
Plinio Alejandro Trinidad-Calderón, Laura Margarita López-Castillo, Salvador Gallegos-Martínez, Grissel Trujillo-de Santiago, Silverio García-Lara, Mario Moisés Álvarez. nurP28, a New-to-Nature Zein-Derived Peptide, Enhances the Therapeutic Effect of Docetaxel in Breast Cancer Monolayers and SpheroidsMolecules 2022; 27(9) doi: 10.3390/molecules27092824
9
Federica Iberite, Marco Piazzoni, Daniele Guarnera, Francesco Iacoponi, Silvia Locarno, Lorenzo Vannozzi, Giacomo Bolchi, Federica Boselli, Irini Gerges, Cristina Lenardi, Leonardo Ricotti. Soft Perfusable Device to Culture Skeletal Muscle 3D Constructs in AirACS Applied Bio Materials 2023; 6(7) doi: 10.1021/acsabm.3c00215
10
Prakash Gangadaran, Eun Jung Oh, Ramya Lakshmi Rajendran, Ji Min Oh, Hyun Mi Kim, Suin Kwak, Ho Yun Chung, Jaetae Lee, Byeong-Cheol Ahn, Chae Moon Hong. Three-dimensional culture conditioned bone marrow MSC secretome accelerates wound healing in a burn injury mouse modelBiochemical and Biophysical Research Communications 2023; 673 doi: 10.1016/j.bbrc.2023.05.088
11
Ronja Pscheid, Esther Drent, Judith Wienke, Josephine G M Strijker, Mark Throsby, Jan J Molenaar. Three-Dimensional Modeling of Solid Tumors and Their Microenvironment to Evaluate T Cell Therapy Efficacy In VitroThe Journal of Immunology 2023; 211(2) doi: 10.4049/jimmunol.2200573
12
Saber Khazaei, Rezvan Amirkhani, Azam Bozorgi, Mozafar Khazaei. Three-Dimensional Culture of Human Dental Pulp Tissue: A Preliminary Experimental In Vitro Model for Regenerative Endodontic ProceduresDental Hypotheses 2023; 14(4) doi: 10.4103/denthyp.denthyp_101_23
13
Cristiano Ceron Jayme, Ananda Ferreira Pires, Daniela Silvestrini Fernandes, Hong Bi, Antonio Claudio Tedesco. DNA polymer films used as drug delivery systems to early-stage diagnose and treatment of breast cancer using 3D tumor spheroids as a modelPhotodiagnosis and Photodynamic Therapy 2022; 37 doi: 10.1016/j.pdpdt.2021.102575
14
Frederika Rentzeperis, Benjamin Coleman, Dorothy Wallace. Cell-Cycle Synchronization Prior to Radiotherapy: A Mathematical Model of the Use of Gemcitabine on Melanoma XenograftsAppliedMath 2024; 4(1) doi: 10.3390/appliedmath4010010
15
Louise Lacalendola Tundisi, Janaína Artem Ataide, Juliana Souza Ribeiro Costa, Diego de Freitas Coêlho, Raquel Bester Liszbinski, André Moreni Lopes, Laura Oliveira-Nascimento, Marcelo Bispo de Jesus, Angela Faustino Jozala, Carsten Ehrhardt, Priscila Gava Mazzola. Nanotechnology as a tool to overcome macromolecules delivery issuesColloids and Surfaces B: Biointerfaces 2023; 222 doi: 10.1016/j.colsurfb.2022.113043
16
Xiaowen Wu, Junxiang Su, Jizhen Wei, Nan Jiang, Xuejun Ge, Valdo Jose Dias Da Silva. Recent Advances in Three-Dimensional Stem Cell Culture Systems and ApplicationsStem Cells International 2021; 2021 doi: 10.1155/2021/9477332
17
Javier Munoz-Garcia, Camille Jubelin, Aurélie Loussouarn, Matisse Goumard, Laurent Griscom, Axelle Renodon-Cornière, Marie-Françoise Heymann, Dominique Heymann. In vitro three-dimensional cell cultures for bone sarcomasJournal of Bone Oncology 2021; 30 doi: 10.1016/j.jbo.2021.100379
18
Sanjay R. Nair, Muhammad Nihad, Sudheer Shenoy P, Sebanti Gupta, Bipasha Bose. Unveiling the effects of micro and nano plastics in embryonic developmentToxicology Reports 2025; 14 doi: 10.1016/j.toxrep.2025.101954
19
Iwona Ziółkowska-Suchanek. Mimicking Tumor Hypoxia in Non-Small Cell Lung Cancer Employing Three-Dimensional In Vitro ModelsCells 2021; 10(1) doi: 10.3390/cells10010141
20
Federica Giordano, Stefania Lenna, Riccardo Rampado, Ava Brozovich, Takashi Hirase, Mauro G. Tognon, Fernanda Martini, Marco Agostini, Jason T. Yustein, Francesca Taraballi. Nanodelivery Systems Face Challenges and Limitations in Bone Diseases ManagementAdvanced Therapeutics 2021; 4(12) doi: 10.1002/adtp.202100152
21
Francesco Muoio, Stefano Panella, Matias Lindner, Valentin Jossen, Yves Harder, Tiziano Moccetti, Regine Eibl, Michele Müller, Tiziano Tallone. Development of a Biodegradable Microcarrier for the Cultivation of Human Adipose Stem Cells (hASCs) with a Defined Xeno- and Serum-Free MediumApplied Sciences 2021; 11(3) doi: 10.3390/app11030925
22
Thais Monteiro, Alex Alves Rodrigues, Giovana Dias da Silva, Esther Carolina dos Santos, Patricia Lima Falcão, Suleyna Ribeiro Prudente, Mayelle Maria Paz, Daniel Perez Vieira. Development of Spheroid in Co-Culture of Prostate Tumor with Human Fibroblast, using the Hanging Drop Technique with Plate Inversion for Analysis of GammaCell220 Irradiation in Co-60<i></i>Brazilian Journal of Radiation Sciences 2026; 14(1) doi: 10.15392/2319-0612.2024.2682
23
Devika Tripathi, Vivek Kumar Gupta, Prashant Pandey. Recent Applications of Tissue-Engineered 3D Scaffolds in Oncology: Present and Future PerspectivesProtein & Peptide Letters 2026; 33(1) doi: 10.2174/0109298665391686251124053211
24
Elvira Immacolata Parrotta, Valeria Lucchino, Luana Scaramuzzino, Stefania Scalise, Giovanni Cuda. Modeling Cardiac Disease Mechanisms Using Induced Pluripotent Stem Cell-Derived Cardiomyocytes: Progress, Promises and ChallengesInternational Journal of Molecular Sciences 2020; 21(12) doi: 10.3390/ijms21124354
25
Jintao Zhong, Wenhua Li, Hetong Li, Jin Zhang, Zuoxu Hou, Xiao Wang, Enhui Zhou, Ke Lu, Weida Zhuang, Hongxun Sang. A self-forming bone membrane generated by periosteum-derived stem cell spheroids enhances the repair of bone defectsActa Biomaterialia 2025; 193 doi: 10.1016/j.actbio.2024.12.058
26
Achilleas G. Mitrakas, Avgi Tsolou, Stylianos Didaskalou, Lito Karkaletsou, Christos Efstathiou, Evgenios Eftalitsidis, Konstantinos Marmanis, Maria Koffa. Applications and Advances of Multicellular Tumor Spheroids: Challenges in Their Development and AnalysisInternational Journal of Molecular Sciences 2023; 24(8) doi: 10.3390/ijms24086949
27
Renata Lima, Vitoria Aparecida Nobrega Antunes, Tais Germano da Costa, Mariana Guilger Casagrande. Biotechnology Applied to Inflammatory DiseasesInterdisciplinary Biotechnological Advances 2023;  doi: 10.1007/978-981-19-8342-9_9
28
Alexandru Blidisel, Iasmina Marcovici, Dorina Coricovac, Florin Hut, Cristina Adriana Dehelean, Octavian Marius Cretu. Experimental Models of Hepatocellular Carcinoma—A Preclinical PerspectiveCancers 2021; 13(15) doi: 10.3390/cancers13153651
29
Yarely M. Salinas-Vera, Jesús Valdés, Alfredo Hidalgo-Miranda, Mireya Cisneros-Villanueva, Laurence A. Marchat, Stephanie I. Nuñez-Olvera, Rosalio Ramos-Payán, Carlos Pérez-Plasencia, Lourdes A. Arriaga-Pizano, Jessica L. Prieto-Chávez, César López-Camarillo. Three-Dimensional Organotypic Cultures Reshape the microRNAs Transcriptional Program in Breast Cancer CellsCancers 2022; 14(10) doi: 10.3390/cancers14102490
30
Teruki Nii, Yasuhiko Tabata. Immunosuppressive mesenchymal stem cells aggregates incorporating hydrogel microspheres promote an in vitro invasion of cancer cellsRegenerative Therapy 2021; 18 doi: 10.1016/j.reth.2021.11.006
31
Chan Hum Park, Jung Ho Park, Yong Joon Suh. Perspective of 3D culture in medicine: transforming disease research and therapeutic applicationsFrontiers in Bioengineering and Biotechnology 2024; 12 doi: 10.3389/fbioe.2024.1491669
32
Marco Cavaco, Patrícia Fraga, Javier Valle, David Andreu, Miguel A. R. B. Castanho, Vera Neves. Development of Breast Cancer Spheroids to Evaluate Cytotoxic Response to an Anticancer PeptidePharmaceutics 2021; 13(11) doi: 10.3390/pharmaceutics13111863
33
Rasoul Yahyapour, Samideh Khoei, Zeinab Kordestani, Mohammad Hasan Larizadeh, Ali Jomehzadeh, Maryam Amirinejad, Meysam Ahmadi-Zeidabadi. Comparative Study of Extremely Low-Frequency Electromagnetic Field, Radiation, and Temozolomide Administration in Spheroid and Monolayer Forms of the Glioblastoma Cell Line (T98)Current Radiopharmaceuticals 2023; 16(2) doi: 10.2174/1874471016666221207163043
34
Aijing Shi, Yixin Shi, Jie Li, Minghan Ye, Xiaoqing Ma, Yuke Peng, Kuo Gai, Junyu Chen. Advancements in 3D gel culture systems for enhanced angiogenesis in bone tissue engineeringJournal of Materials Chemistry B 2025; 13(11) doi: 10.1039/D4TB01139B
35
Patrik Macášek, Adriana Kapustová, Jitka Viktorová, Ján Víglaš, Petra Olejníková, Lukas Grey, Lucia Laubertová, Helena Gbelcová. Agar Composition Modulates Production of Trichoderma Peptaibols, Affecting Antibacterial and Antiproliferative ActivityCurrent Microbiology 2025; 82(8) doi: 10.1007/s00284-025-04322-x
36
Elena Morrocchi, Simon van Haren, Paolo Palma, Ofer Levy. Modeling human immune responses to vaccination in vitroTrends in Immunology 2024; 45(1) doi: 10.1016/j.it.2023.11.002
37
Yarely M. Salinas-Vera, Jesús Valdés, Yussel Pérez-Navarro, Stephanie I. Nuñez-Olvera, Mercedes Bermúdez, Eloisa Ibarra-Sierra, María Elizbeth Álvarez-Sánchez, Nancy L. Martínez- Rodriguez, Macrina B. Silva-Cázares, Laurence A. Marchat, César López-Camarillo. A three-dimensional microenvironment rewires the transcriptome and reveals the regulation of the SNHG7/miR-486-3p/HIF1A axis in breast cancer cellsHeliyon 2026; 12(10) doi: 10.1016/j.heliyon.2026.e45063
38
Perla Uc, Jael Miranda, Arturo Raya‑Sandino, Lourdes Alarc�n, Mar�a Rold�n, Rodolfo Ocadiz‑Delgado, Enoc Cort�s‑Malag�n, Bibiana Ch�vez‑Mungu�a, Georgina Ram�rez, Ren� Asomoza, Liora Shoshani, Patricio Gariglio, Lorenza Gonz�lez‑Mariscal. E7 oncoprotein from human papillomavirus 16 alters claudins expression and the sealing of epithelial tight junctionsInternational Journal of Oncology 2020;  doi: 10.3892/ijo.2020.5105
39
Nadab H. Wubshet, Grace Cai, Samuel J. Chen, Molly Sullivan, Mark Reeves, David Mays, Morgan Harrison, Paul Varnado, Benjamin Yang, Esmeralda Arreguin-Martinez, Yunjia Qu, Shan-Shan Lin, Pamela Duran, Carlos Aguilar, Shelby Giza, Twyman Clements, Allen P. Liu. Cellular mechanotransduction of human osteoblasts in microgravitynpj Microgravity 2024; 10(1) doi: 10.1038/s41526-024-00386-4
40
Thuy Trang Truong, Yu Bin Lee, Kyoung Hwan Park, Hye-Eun Shim, Jin Jung Song, Hyung-Sun Kim, Jeong Ho Hwang, Sun-Woong Kang, Kang Moo Huh. Cryopreservable three-dimensional spheroid culture for ready-to-use systemsKorean Journal of Chemical Engineering 2023; 40(2) doi: 10.1007/s11814-022-1279-9
41
Yamin Yang, Sijia Liu, Chunxiao Chen, Haipeng Huang, Ling Tao, Zhiyu Qian, Weitao Li. Microfluidic-enabled self-organized tumor model for in vitro cytotoxicity assessment of doxorubicinBiomedical Microdevices 2020; 22(4) doi: 10.1007/s10544-020-00523-2
42
Cian-Ru Yang, Chu-Ting Liang, Shih-Chieh Tsai, Yu-Chun Wu, Ching-Wen Liu, Hui-Hua Yang, Ting-Yuan Tu, Yueh-Chun Lee, Kuei-Yang Hsiao, Wei-Chun Chang, Wen-Lung Ma. A Novel 3D Culture Scaffold to Shorten Development Time for Multicellular Tumor SpheroidsInternational Journal of Molecular Sciences 2022; 23(22) doi: 10.3390/ijms232213962
43
Vasavi Pasupuleti, Lalitkumar Vora, Renuka Prasad, D.N. Nandakumar, Dharmendra Kumar Khatri. Glioblastoma preclinical models: Strengths and weaknessesBiochimica et Biophysica Acta (BBA) - Reviews on Cancer 2024; 1879(1) doi: 10.1016/j.bbcan.2023.189059
44
Salvador Gallegos-Martínez, Itzel Montserrat Lara-Mayorga, Mohamadmahdi Samandari, Christian Mendoza-Buenrostro, Brenda Giselle Flores-Garza, Luisa María Reyes-Cortés, Juan Carlos Segoviano-Ramírez, Yu Shrike Zhang, Grissel Trujillo-de Santiago, Mario Moisés Álvarez. Culture of cancer spheroids and evaluation of anti-cancer drugs in 3D-printed miniaturized continuous stirred tank reactors (mCSTRs)Biofabrication 2022; 14(3) doi: 10.1088/1758-5090/ac61a4
45
Taylor Do, Lilly Synan, Gibran Ali, Heather Gappa-Fahlenkamp. 3D tissue-engineered lung models to study immune responses following viral infections of the small airwaysStem Cell Research & Therapy 2022; 13(1) doi: 10.1186/s13287-022-03134-1
46
Nkune Williams Nkune, Heidi Abrahamse. Anti-Hypoxia Nanoplatforms for Enhanced Photosensitizer Uptake and Photodynamic Therapy Effects in Cancer CellsInternational Journal of Molecular Sciences 2023; 24(3) doi: 10.3390/ijms24032656
47
Marwa Ibrahim Salman, Ahmed Majeed Al-Shammari, Mahfodha Abbas Emran. 3-Dimensional coculture of breast cancer cell lines with adipose tissue–Derived stem cells reveals the efficiency of oncolytic Newcastle disease virus infection via labeling technologyFrontiers in Molecular Biosciences 2022; 9 doi: 10.3389/fmolb.2022.754100
48
Abi Jones, Charlotte Hulme, Tom Link, Helen McCarthy, Zaid Maniar, Jade Perry, Karina Wright. Cell Therapy2025;  doi: 10.1007/978-981-96-1261-1_19
49
Mishra Bharti, Khan Anam, Gothalwal Ragini, Jaiswal Prashansa, Kotnis Ashwin. Stem Cell Therapy in Dermatological Disorders2025;  doi: 10.1002/9781394393145.ch11
50
Anastasia N. Shishparenok, Vitalina V. Furman, Natalia V. Dobryakova, Dmitry D. Zhdanov. Protein Immobilization on Bacterial Cellulose for Biomedical ApplicationPolymers 2024; 16(17) doi: 10.3390/polym16172468
51
Tan Tang, Peipei Zhang, Yanran Wei, Hongxing Jia, Lin Feng, Ye Xu. High-efficiency 3D cell spheroid formation via the inertial focusing effect in rotating dropletsBio-Design and Manufacturing 2023; 6(1) doi: 10.1007/s42242-022-00211-5
52
Shiya Lv, Enhui He, Jinping Luo, Yaoyao Liu, Wei Liang, Shihong Xu, Kui Zhang, Yan Yang, Mixia Wang, Yilin Song, Yirong Wu, Xinxia Cai. Using Human‐Induced Pluripotent Stem Cell Derived Neurons on Microelectrode Arrays to Model Neurological Disease: A ReviewAdvanced Science 2023; 10(33) doi: 10.1002/advs.202301828
53
P.V. Migisha Ntwali, Chae Eun Heo, Jong Yoon Han, Soo Yeon Chae, Minji Kim, Hung M. Vu, Min-Sik Kim, Hugh I. Kim. Mass spectrometry-based proteomics of single cells and organoids: The new generation of cancer researchTrAC Trends in Analytical Chemistry 2020; 130 doi: 10.1016/j.trac.2020.116005
54
Sanyog Jain, Kaisar Raza, Ashish Kumar Agrawal, Ankur Vaidya. Nanotechnology Applications for Cancer Chemotherapy2021;  doi: 10.1016/B978-0-12-817846-1.00027-8
55
Yuuki Shichi, Fujiya Gomi, Norihiko Sasaki, Keisuke Nonaka, Tomio Arai, Toshiyuki Ishiwata. Epithelial and Mesenchymal Features of Pancreatic Ductal Adenocarcinoma Cell Lines in Two- and Three-Dimensional CulturesJournal of Personalized Medicine 2022; 12(5) doi: 10.3390/jpm12050746
56
Quan Ma, Hai Lei, Yi Cao. Intramolecular Covalent Bonds in Gram‐Positive Bacterial Surface ProteinsChemBioChem 2022; 23(20) doi: 10.1002/cbic.202200316
57
Marta Nowacka, Karolina Sterzynska, Malgorzata Andrzejewska, Michal Nowicki, Radoslaw Januchowski. Drug resistance evaluation in novel 3D in vitro modelBiomedicine & Pharmacotherapy 2021; 138 doi: 10.1016/j.biopha.2021.111536
58
Nkune Williams Nkune, Nokuphila Winifred Nompumelelo Simelane, Hanieh Montaseri, Heidi Abrahamse. Photodynamic Therapy-Mediated Immune Responses in Three-Dimensional Tumor ModelsInternational Journal of Molecular Sciences 2021; 22(23) doi: 10.3390/ijms222312618
59
Joonhwa Choi, JinKi Min, Dohyung Kim, Jin Kim, Jinsol Kim, Hyeokjun Yoon, Jinwoo Lee, Youngin Jeong, C-Yoon Kim, Seung Hwan Ko. Hierarchical 3D Percolation Network of Ag–Au Core–Shell Nanowire-Hydrogel Composite for Efficient Biohybride ElectrodesACS Nano 2023; 17(18) doi: 10.1021/acsnano.3c04292
60
Guya Diletta Marconi, Antonella Mazzone, Ylenia Della Rocca, Oriana Trubiani, Jacopo Pizzicannella, Francesca Diomede. Three-Dimensional Culture System: A New Frontier in Cancer Research, Drug Discovery, and Stem Cell-Based TherapyBiology 2025; 14(7) doi: 10.3390/biology14070875
61
Vaishali Aggarwal, Catalina Ardila Montoya, Vera S. Donnenberg, Shilpa Sant. Interplay between tumor microenvironment and partial EMT as the driver of tumor progressioniScience 2021; 24(2) doi: 10.1016/j.isci.2021.102113
62
Daniella Da Silva, Anine Crous, Heidi Abrahamse. Enhancing Osteoblast Differentiation from Adipose-Derived Stem Cells Using Hydrogels and Photobiomodulation: Overcoming In Vitro Limitations for Osteoporosis TreatmentCurrent Issues in Molecular Biology 2024; 46(7) doi: 10.3390/cimb46070379
63
Everton Freitas de Morais, Leonardo de Oliveira Siquara da Rocha, John Lenon de Souza Santos, Raíza Dias Freitas, Bruno Solano de Freitas Souza, Ricardo D. Coletta, Clarissa A. Gurgel Rocha. Use of Three-Dimensional Cell Culture Models in Drug Assays for Anti-Cancer Agents in Oral Cancer: Protocol for a Scoping ReviewJournal of Personalized Medicine 2023; 13(11) doi: 10.3390/jpm13111618
64
Sandra Cordeiro, Beatriz B. Oliveira, Ruben Valente, Daniela Ferreira, André Luz, Pedro V. Baptista, Alexandra R. Fernandes. Breaking the mold: 3D cell cultures reshaping the future of cancer researchFrontiers in Cell and Developmental Biology 2024; 12 doi: 10.3389/fcell.2024.1507388
65
Yadong Yang, Geng Yang, Xingzhu Liu, Yimeng Xu, Siyu Zhao, Wenyuan Zhang, Mengjiao Xu. Construction of Lung Tumor Model for Drug Screening Based on 3D Bio-Printing TechnologyJournal of Biomaterials and Tissue Engineering 2021; 11(7) doi: 10.1166/jbt.2021.2706
66
Xiaoyan Lyu, Feiyun Cui, Hang Zhou, Bo Cao, Xiaolan Zhang, Minghui Cai, Shulong Yang, Bangyong Sun, Gang Li. 3D co-culture of macrophages and fibroblasts in a sessile drop array for unveiling the role of macrophages in skin wound-healingBiosensors and Bioelectronics 2023; 225 doi: 10.1016/j.bios.2023.115111
67
Haobin Zhao, Ruining Han, Zhankun Wang, Junfang Xian, Xiaosu Bai. Colorectal Cancer Stem Cells and Targeted AgentsPharmaceutics 2023; 15(12) doi: 10.3390/pharmaceutics15122763
68
Vincenza De Gregorio, Alessia La Rocca, Francesco Urciuolo, Clorinda Annunziata, Maria Lina Tornesello, Franco Maria Buonaguro, Paolo Antonio Netti, Giorgia Imparato. Modeling the epithelial-mesenchymal transition process in a 3D organotypic cervical neoplasiaActa Biomaterialia 2020; 116 doi: 10.1016/j.actbio.2020.09.006
69
Dilek Bahar, Senem Akkoç, Buket Banu Özkan. Antiproliferative effect of silver compounds containing benzimidazole ringTrakya University Journal of Natural Sciences 2025; 26(1) doi: 10.23902/trkjnat.1549105
70
Hongda Zhao, Vincy Wing Sze Ho, Kang Liu, Xuan Chen, Hongwei Wu, Peter Ka-Fung Chiu, Lu-Yan Chan, Steffi Kar-Kei Yuen, David Ka-Wai Leung, Alex Qinyang Liu, Chris Ho-Ming Wong, Ivan Ching-Ho Ko, Chi Fai Ng, Dinglan Wu, Jeremy Yuen-Chun Teoh. Organoid models in bladder cancer: From bench to bedside?Bladder Cancer 2025; 11(2) doi: 10.1177/23523735251330404
71
Gamze Demirel, Gürsel Koltuk. The importance of 3D cell culture in drug discovery and developmentFrontiers in Life Sciences and Related Technologies 2024; 5(3) doi: 10.51753/flsrt.1488871
72
Suyeong Seo, Seung‐Yeol Nah, Kangwon Lee, Nakwon Choi, Hong Nam Kim. Triculture Model of In Vitro BBB and its Application to Study BBB‐Associated Chemosensitivity and Drug Delivery in GlioblastomaAdvanced Functional Materials 2022; 32(10) doi: 10.1002/adfm.202106860
73
Antonio Varone, Justin Ke Nguyen, Lian Leng, Riccardo Barrile, Josiah Sliz, Carolina Lucchesi, Norman Wen, Achille Gravanis, Geraldine A. Hamilton, Katia Karalis, Christopher D. Hinojosa. A novel organ-chip system emulates three-dimensional architecture of the human epithelia and the mechanical forces acting on itBiomaterials 2021; 275 doi: 10.1016/j.biomaterials.2021.120957
74
Xingxing Liu, Qiuping Su, Xiaoyu Zhang, Wenjian Yang, Junhua Ning, Kangle Jia, Jinlan Xin, Huanling Li, Longfei Yu, Yuheng Liao, Diming Zhang. Recent Advances of Organ-on-a-Chip in Cancer Modeling ResearchBiosensors 2022; 12(11) doi: 10.3390/bios12111045
75
Recapitulating the Stem Cell Niche Ex VivoAdvances in Stem Cells and their Niches 2022; 6 doi: 10.1016/bs.asn.2022.05.001
76
Joana Rita Oliveira Faria Marques, Patricia González-Alva, Ruby Yu-Tong Lin, Beatriz Ferreira Fernandes, Akhilanand Chaurasia, Nileshkumar Dubey. Advances in tissue engineering of cancer microenvironment-from three-dimensional culture to three-dimensional printingSLAS Technology 2023; 28(3) doi: 10.1016/j.slast.2023.03.005
77
Meryem Damla Özdemir Alkış, Gözde Baydemir Peşint, Dilek Göktürk. Advancing glioblastoma research: A comparative study of drug response in novel 3D pHEMA-gelatin cryogel and traditional 2D modelsJournal of Materials Research 2025; 40(12) doi: 10.1557/s43578-025-01613-8
78
Marika Musielak, Barbara Szymkowiak, Agnieszka Boś-Liedke. comparison of gold nanoparticles effectiveness in 2D and 3D cell culture. Letters in Oncology Science 2023; 20(1) doi: 10.21641/los.2023.20.1.239
79
Hidetaka Ueno, Shohei Yamamura. Fabrication Method for Shape-Controlled 3D Tissue Using High-Porosity Porous StructureBioengineering 2024; 11(2) doi: 10.3390/bioengineering11020160
80
Łucja Justyna Walczak, Monika Gawrońska-Grzywacz, Marta Arczewska, Monika Pitucha, Elżbieta Kochanowicz, Mariola Herbet. Evaluation of antitumor potential of novel semicarbazide-based derivatives: cytotoxicity, angiogenesis modulation, and cell cycle effects in in vitro and in vivo modelsAdvances in Medical Sciences 2026;  doi: 10.1016/j.advms.2026.06.001
81
Ramesh Bhonde. Future of Regenerative MedicineMedical Journal of Dr. D.Y. Patil Vidyapeeth 2022; 15(2) doi: 10.4103/mjdrdypu.mjdrdypu_651_20
82
Archana Singh, Juili Mirgule, Mamatha M. Pillai, Neha Dalal, Prakriti Tayalia. Particulate leaching improves spheroid formation in PEG and gelatin-based matrices for 3D tumor modelMaterials Today Communications 2022; 31 doi: 10.1016/j.mtcomm.2022.103494
83
Boyu Zheng, Jingyi Tang, Chuanxiong Nie, Yuhang Jiang, Mathias Dimde, Wenzhong Li, Rainer Haag. Oxidized cellulose nanofibril hydrogel as a 3D scaffold for breast tumor spheroid expansion and microenvironment modelingInternational Journal of Biological Macromolecules 2026; 338 doi: 10.1016/j.ijbiomac.2025.149716
84
Eric K. N. Gähwiler, Sarah E. Motta, Marcy Martin, Bramasta Nugraha, Simon P. Hoerstrup, Maximilian Y. Emmert. Human iPSCs and Genome Editing Technologies for Precision Cardiovascular Tissue EngineeringFrontiers in Cell and Developmental Biology 2021; 9 doi: 10.3389/fcell.2021.639699
85
Orada Sriwatananukulkit, Tulyapruek Tawonsawatruk, Kasem Rattanapinyopituk, Ticomporn Luangwattanawilai, Narongrit Srikaew, Ruedee Hemstapat. Scaffold-Free Cartilage Construct from Infrapatellar Fat Pad Stem Cells for Cartilage RestorationTissue Engineering Part A 2022; 28(5-6) doi: 10.1089/ten.tea.2020.0167
86
Keyue Wu, Qingyue Meng, Xuhua Nong, Xinye Chen, Yonghong Liu, Simon Wing-Fai Mok, Riming Huang, Xiaoyong Zhang. New insights into the cytotoxic mechanism of marine-fungus-derived citrinin in three-dimensional Hepa1-6 cell modelComparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 2025; 294 doi: 10.1016/j.cbpc.2025.110196
87
Lara S. Costard, Ryan R. Hosn, Harumi Ramanayake, Fergal J. O'Brien, Caroline M. Curtin. Influences of the 3D microenvironment on cancer cell behaviour and treatment responsiveness: A recent update on lung, breast and prostate cancer modelsActa Biomaterialia 2021; 132 doi: 10.1016/j.actbio.2021.01.023
88
Ajeya Nandi, Rumela Chakrabarti. Stem Cell AssaysMethods in Molecular Biology 2022; 2429 doi: 10.1007/978-1-0716-1979-7_33
89
Alexander Bäumchen, Johnn Majd Balsters, Beate-Sophie Nenninger, Stefan Diebels, Heiko Zimmermann, Michael Roland, Michael M. Gepp. Towards a Comprehensive Framework for Made-to-Measure Alginate Scaffolds for Tissue Engineering Using Numerical SimulationGels 2025; 11(3) doi: 10.3390/gels11030185
90
Sanaz Khaseb, Mahdi Kohansal Vajari, Mina Soufi Zomorrod, Maryam Rezai Rad, Monireh Ajami, Mansoureh Ajami, Saba Sadeghpour, Amir Atashi. Effect of fibrin on the expression of adhesion molecules (ICAM-1, ITGAV, and ITGB3) in unrestricted somatic stem cellsHematology, Transfusion and Cell Therapy 2025; 47(2) doi: 10.1016/j.htct.2025.103827
91
Parmida Sadat Pezeshki, Nima Rezaei. Cancer and Targeting the Immune SystemHandbook of Cancer and Immunology 2025; 6 doi: 10.1007/978-3-032-00767-4_206
92
Marta G. Valverde, Luis S. Mille, Kianti P. Figler, Ernesto Cervantes, Vanessa Y. Li, Joseph V. Bonventre, Rosalinde Masereeuw, Yu Shrike Zhang. Biomimetic models of the glomerulusNature Reviews Nephrology 2022; 18(4) doi: 10.1038/s41581-021-00528-x
93
Deivid Martins Santos, Edmarcia Elisa de Souza, Janaina Macedo-da-Silva, Sueli Mieko Oba-Shinjo, Claudia Blanes Angeli, Vinícius de Morais Gomes, Simon Ngao Mule, Lays Adrianne Mendonça Trajano, Guilherme Antonio de Souza-Silva, Silvia Beatriz Boscardin, Edison Luiz Durigon, Ruy Gastaldoni Jaeger, Vanessa Morais Freitas, Carsten Wrenger, Martin Røssel Larsen, Livia Rosa-Fernandes, Suely Kazue Nagashi Marie, Giuseppe Palmisano. Molecular Characterization of Calu-3 Cells from Submerged to Air–Liquid Interface to Model Lung InfectionsJournal of Proteome Research 2026; 25(2) doi: 10.1021/acs.jproteome.4c00975
94
Ryotaro Kazama, Satoshi Fujita, Shinji Sakai. Cell Dome as an Evaluation Platform for Organized HepG2 CellsCells 2022; 12(1) doi: 10.3390/cells12010069
95
Swapnil Raut, Lokesh Kumar Bhatt, Aman B. Upaganlawar, Bhupendra G. Prajapati. Colorectal Cancer2024;  doi: 10.1016/B978-0-443-13870-6.00015-5
96
Chawon Yun, Sou Hyun Kim, Kyung Mok Kim, Min Hye Yang, Mi Ran Byun, Joung-Hee Kim, Doyoung Kwon, Huyen T. M. Pham, Hyo-Sop Kim, Jae-Ho Kim, Young-Suk Jung. Advantages of Using 3D Spheroid Culture Systems in Toxicological and Pharmacological Assessment for Osteogenesis ResearchInternational Journal of Molecular Sciences 2024; 25(5) doi: 10.3390/ijms25052512
97
Peng Tang, Boonya Thongrom, Smriti Arora, Rainer Haag. Polyglycerol‐Based Biomedical Matrix for Immunomagnetic Circulating Tumor Cell Isolation and Their Expansion into Tumor Spheroids for Drug ScreeningAdvanced Healthcare Materials 2023; 12(26) doi: 10.1002/adhm.202300842
98
Maria Assunta Signore, Chiara De Pascali, Lucia Giampetruzzi, Pietro Aleardo Siciliano, Luca Francioso. Gut-on-Chip microphysiological systems: Latest advances in the integration of sensing strategies and adoption of mature detection mechanismsSensing and Bio-Sensing Research 2021; 33 doi: 10.1016/j.sbsr.2021.100443
99
Chitra Jaiswal, Bibrita Bhar, Saki Sugihara, Biman B. Mandal. Bioengineered In Vitro 3D Cancer Models: A New Paradigm in Ethical and Predictive Oncology Research Toward Successful Pre‐Clinical Drug ScreeningSmall 2026; 22(28) doi: 10.1002/smll.202513199
100
Hadis Abdolahzadeh, Niloofar Khoshdel Rad, Anastasia Shpichka, Reihaneh Golroo, Kosar Rahi, Peter Timashev, Moustapha Hassan, Massoud Vosough. Progress and promise of cell sheet assisted cardiac tissue engineering in regenerative medicineBiomedical Materials 2023; 18(3) doi: 10.1088/1748-605X/acbad4
101
D. Isabel Petrescu, Jason T. Yustein, Atreyi Dasgupta. Preclinical models for the study of pediatric solid tumors: focus on bone sarcomasFrontiers in Oncology 2024; 14 doi: 10.3389/fonc.2024.1388484
102
Edgar G. Ordóñez-Rubiano, Nicolás Rincón-Arias, William J. Shelton, Andres F. Salazar, María Alejandra Sierra, Raphael Bertani, Diego F. Gómez-Amarillo, Fernando Hakim, Matías Baldoncini, César Payán-Gómez, Alba Lucia Cómbita, Sandra C. Ordonez-Rubiano, Rafael Parra-Medina. Current Applications of Single-Cell RNA Sequencing in Glioblastoma: A Scoping ReviewBrain Sciences 2025; 15(3) doi: 10.3390/brainsci15030309
103
Zilong Li, Jiaqing Dong, Wenhua Zhong, Guijun Wang, Xuan Liu, Qiegen Liu, Xianlin Song. Motionless shape-from-focus depth measurement via high-speed axial optical scanningOptics Communications 2023; 546 doi: 10.1016/j.optcom.2023.129756
104
Simona Dobiasová, Nikoletta Szemerédi, Denisa Kučerová, Kamila Koucká, Radka Václavíková, Helena Gbelcová, Tomáš Ruml, Enrique Domínguez-Álvarez, Gabriella Spengler, Jitka Viktorová. Ketone-selenoesters as potential anticancer and multidrug resistance modulation agents in 2D and 3D ovarian and breast cancer in vitro modelsScientific Reports 2022; 12(1) doi: 10.1038/s41598-022-10311-y
105
Keykavos Gholami, Mehrnaz Izadi, Ramin Heshmat, Seyed Mohammad Kazem Aghamir. Exploring the potential of solid and liquid amniotic membrane biomaterial in 3D models for prostate cancer research: A comparative analysis with 2D modelsTissue and Cell 2025; 93 doi: 10.1016/j.tice.2025.102726
106
Chui-Wei Wong, Hao-Wei Han, Shan-hui Hsu. Changes of cell membrane fluidity for mesenchymal stem cell spheroids on biomaterial surfacesWorld Journal of Stem Cells 2022; 14(8): 616-632 doi: 10.4252/wjsc.v14.i8.616
107
Yihe Wang, Mengqi Liu, Yu Zhang, Hong Liu, Lin Han. Recent methods of droplet microfluidics and their applications in spheroids and organoidsLab on a Chip 2023; 23(5) doi: 10.1039/D2LC00493C
108
Dong-Soo Kang, Soo-Yeon Yang, Chang-Yull Lee. Fabrication of innocuous hydrogel scaffolds based on modified dextran for biotissuesCarbohydrate Research 2022; 522 doi: 10.1016/j.carres.2022.108699
109
Xiaoying Hou, Cong Du, Ligong Lu, Shengtao Yuan, Meixiao Zhan, Pengtao You, Hongzhi Du. Opportunities and challenges of patient-derived models in cancer research: patient-derived xenografts, patient-derived organoid and patient-derived cellsWorld Journal of Surgical Oncology 2022; 20(1) doi: 10.1186/s12957-022-02510-8
110
Ji Min Oh, Prakash Gangadaran, Ramya Lakshmi Rajendran, Chae Moon Hong, Jaetae Lee, Byeong-Cheol Ahn. Different Expression of Thyroid-Specific Proteins in Thyroid Cancer Cells between 2-Dimensional (2D) and 3-Dimensional (3D) Culture EnvironmentCells 2022; 11(22) doi: 10.3390/cells11223559
111
Yingxuan Zhu, Mengqi Zhang, Qingqing Sun, Xiaofeng Wang, Xiaomeng Li, Qian Li. Advanced Mechanical Testing Technologies at the Cellular Level: The Mechanisms and Application in Tissue EngineeringPolymers 2023; 15(15) doi: 10.3390/polym15153255
112
Xu Zhang, Mengqian Zhao, Pengwei Deng, Haitao Liu, Hongjing Li, Xiaoqing Zhang, Daqing Wang, Jianhua Qin. Modeling Idiopathic Inflammatory Myopathy in the Bioinspired Muscle Tissue on ChipAdvanced Healthcare Materials 2025; 14(16) doi: 10.1002/adhm.202405111
113
Yan Kong, Linzhi Jing, Dejian Huang. Plant proteins as the functional building block of edible microcarriers for cell-based meat culture applicationCritical Reviews in Food Science and Nutrition 2024; 64(15) doi: 10.1080/10408398.2022.2147144
114
Annie Agnes Suganya Samson, Sandip Gangadhar Balwe, Sera Hong, Joon Myong Song. Verification of Nanomaterial-Induced Size-Dependent Human Ether-à-Go-Go-Related Gene Potassium Channel Blockage Using Three-Dimensional Bioengineered Functional Cardiac Tissue ConstructsChemistry of Materials 2023; 35(2) doi: 10.1021/acs.chemmater.2c03249
115
Ann-Katrin Piper, Chelsea Penney, Jacqueline Holliday, Gary Tincknell, Yafeng Ma, Sarbar Napaki, Klaus Pantel, Daniel Brungs, Marie Ranson. EGFR and PI3K Signalling Pathways as Promising Targets on Circulating Tumour Cells from Patients with Metastatic Gastric AdenocarcinomaInternational Journal of Molecular Sciences 2024; 25(10) doi: 10.3390/ijms25105565
116
Jiahao Wu, Zhitong Li, Weilin Meng, Haobin Zheng, Fan Jiang, Mingjun Chen, Chunya Wu. Model Design and Path Optimization of Perfusable Chips in Extrusion-Based Bioprinting: Linking Hydrogel Rheology with Structural FeaturesACS Biomaterials Science & Engineering 2026; 12(2) doi: 10.1021/acsbiomaterials.5c01878
117
Sarah Tonello, Andrea Bianchetti, Simona Braga, Camillo Almici, Mirella Marini, Giovanna Piovani, Michele Guindani, Kamol Dey, Luciana Sartore, Federica Re, Domenico Russo, Edoardo Cantù, Nicola Francesco Lopomo, Mauro Serpelloni, Emilio Sardini. Impedance-Based Monitoring of Mesenchymal Stromal Cell Three-Dimensional Proliferation Using Aerosol Jet Printed Sensors: A Tissue Engineering ApplicationMaterials 2020; 13(10) doi: 10.3390/ma13102231
118
Prativa Das, Sahar Najafikhoshnoo, Jorge A. Tavares-Negrete, Qian Yi, Rahim Esfandyarpour. An in-vivo-mimicking 3D lung cancer-on-a-chip model to study the effect of external stimulus on the progress and inhibition of cancer metastasisBioprinting 2022; 28 doi: 10.1016/j.bprint.2022.e00243
119
Keerti Maheshwari, Pankaj Musyuni, Amitava Moulick, Harshita Mishra, Adam Ekielski, Pawan Kumar Mishra, Geeta Aggarwal. Unveiling the microbial symphony: Next-Gen sequencing and bioinformatics insights into the human gut microbiomeHealth Sciences Review 2024; 11 doi: 10.1016/j.hsr.2024.100173
120
Thi Phuong Truc Nguyen, Thi Thu Hoai Nguyen. Model Organisms in Biological Research2026;  doi: 10.1007/978-981-92-0038-2_15
121
Ilias Nikolits, Sabrina Nebel, Dominik Egger, Sebastian Kreß, Cornelia Kasper. Towards Physiologic Culture Approaches to Improve Standard Cultivation of Mesenchymal Stem CellsCells 2021; 10(4) doi: 10.3390/cells10040886
122
Xie Chen, Tao Sun, Zihou Wei, Zhe Chen, Huaping Wang, Qiang Huang, Toshio Fukuda, Qing Shi. A clamp-free micro-stretching system for evaluating the viscoelastic response of cell-laden microfibersBiosensors and Bioelectronics 2022; 214 doi: 10.1016/j.bios.2022.114517
123
Jhonatan Rafael de Oliveira Bianchi, Ana Letícia Rodrigues Costa, Hernandes F. Carvalho, Lucimara Gaziola de La Torre. Current challenges and bioengineering aspects in the development of an in vitro model of the human intestinal epitheliumBiomedical Engineering Advances 2025; 10 doi: 10.1016/j.bea.2025.100188
124
Zhidan Sun, Chenglong Ding, Yuhan Wang, Tingting Lu, Wencheng Song. Plasma-Activated Medium Inhibited the Proliferation and Migration of Non-Small Cell Lung Cancer A549 Cells in 3D CultureInternational Journal of Molecular Sciences 2024; 25(24) doi: 10.3390/ijms252413262
125
Tung Dinh Do, Uyen Thu Pham, Linh Phuong Nguyen, Trang Minh Nguyen, Cuong Nguyen Bui, Susan Oliver, Phuong Pham, Toan Quoc Tran, Bich Thi Hoang, Minh Thi Hong Pham, Dung Thuy Nguyen Pham, Duong Thanh Nguyen. Fabrication of a Low-Cost Microfluidic Device for High-Throughput Drug Testing on Static and Dynamic Cancer Spheroid Culture ModelsDiagnostics 2023; 13(8) doi: 10.3390/diagnostics13081394
126
Simona Braccini, Chiara Tacchini, Federica Chiellini, Dario Puppi. Polymeric Hydrogels for In Vitro 3D Ovarian Cancer ModelingInternational Journal of Molecular Sciences 2022; 23(6) doi: 10.3390/ijms23063265
127
Kuan-Ming Lin, Yong-Ren Chen, Ming-Hua Ho, Chung-Hsing Li. The cell-fate decision of dental follicle stem cells (DFSCs) with porcine corneal extracellular matrix (ECM)Journal of Dental Sciences 2025; 20(3) doi: 10.1016/j.jds.2025.02.019
128
Teodora Eliana Petcov, Mihai Straticiuc, Decebal Iancu, Dragoș Alexandru Mirea, Roxana Trușcă, Paul Emil Mereuță, Diana Iulia Savu, George Dan Mogoșanu, Laurențiu Mogoantă, Roxana Cristina Popescu, Verena Kopatz, Sorin Ion Jinga. Unveiling Nanoparticles: Recent Approaches in Studying the Internalization Pattern of Iron Oxide Nanoparticles in Mono- and Multicellular Biological StructuresJournal of Functional Biomaterials 2024; 15(6) doi: 10.3390/jfb15060169
129
Ana Rita Garcia, Maria Alexandra Brito. Breast Cancer Pathophysiology: An Interdisciplinary ApproachInterdisciplinary Cancer Research 2023; 5 doi: 10.1007/16833_2023_154
130
Mennatullah M. Khalil, Maryam Ibrahim, Surendra Singh Rawat, Mohamed Jamal. Comparative evaluation of 3D culture strategies for pulp-dentin modelsBMC Oral Health 2026; 26(1) doi: 10.1186/s12903-025-07561-3
131
Bahar Demir Cevizlidere, Onur Uysal, Huseyin Avci, Sibel Gunes Bagis, Tugba Semerci Sevimli, Murat Dincer, Emilia Qomi Ekenel, Suleyman Gokhan Kara, Merve Nur Soykan, Ayla Eker Sariboyaci. Establishment, culture and characterization of gemcitabine hydrochloride‐resistant human non‐small cell lung carcinoma cell line derived cancer stem cellsCell Biochemistry and Function 2024; 42(4) doi: 10.1002/cbf.4079
132
Arnab Saha, Prakriti Mahlawat, Mohit Kumar, Naval V. Koralkar. Nanoparticle Delivery in Cancer CareSeries in BioEngineering 2025;  doi: 10.1007/978-981-95-0457-2_2
133
Jhonatan Rafael de Oliveira Bianchi, Bruna Gregatti Carvalho, Hernandes F. Carvalho, Lucimara Gaziola de la Torre. Microfluidic-based gelatin methacrylate microgel as a scaffold to create reverse-polarity HT29 spheroidsInternational Journal of Biological Macromolecules 2025; 305 doi: 10.1016/j.ijbiomac.2025.140824
134
Jiang Wu, Siqi Liu, Xiaowen Zeng, Yang Li, Yinlin Yao, Jing Wang, Guangdong Hu, Kai Kang. Construction and Performance Evaluation of an Astaxanthin–Chitosan/Chitooligosaccharide Hydrogel System for Ex Vivo Culture of Murine Spermatogonial Stem CellsBiology 2025; 14(12) doi: 10.3390/biology14121664
135
Maira Moreno Valtierra, Adriana Urue Corral, Jorge Armando Jiménez-Avalos, Erika Barbosa Avalos, Judith Dávila-Rodríguez, Norma Morales Hernández, Mauricio Comas-García, Guillermo Toriz González, Antonio Oceguera-Villanueva, José Alfonso Cruz-Ramos, Rodolfo Hernández Gutiérrez, Moisés Martínez Velázquez, Zaira Yunuen García Carvajal. Patterned PVA Hydrogels with 3D Petri Dish® Micro-Molds of Varying Topography for Spheroid Formation of HeLa Cancer Cells: In Vitro AssessmentGels 2024; 10(8) doi: 10.3390/gels10080518
136
Zhen Hu, Yun-E Xu, Jie Zhang, Xue Luo, Jia-Zhe Li, Yu-Tong Wang, Heng-Mei Li, Xin Sun, Sheng-Yu Wang, Hong Song, Di-Shu Ao. Construction of a Three-Dimensional Culture Model of HSV-1 Based on the Nano-Self-Assembling Peptide RADA16-I and Preliminary Exploration of the Relationship Between HSV-1 and AutophagyMicroorganisms 2026; 14(3) doi: 10.3390/microorganisms14030601
137
Shuqian Wan, Ulises Aregueta Robles, Laura Poole-Warren, Dorna Esrafilzadeh. Advances in 3D tissue models for neural engineering: self-assembled versus engineered tissue modelsBiomaterials Science 2024; 12(14) doi: 10.1039/D4BM00317A
138
Tarek Saydé, Omar El Hamoui, Bruno Alies, Karen Gaudin, Gaëtane Lespes, Serge Battu. Biomaterials for Three-Dimensional Cell Culture: From Applications in Oncology to NanotechnologyNanomaterials 2021; 11(2) doi: 10.3390/nano11020481
139
Deniz Bakkalci, Amrita Jay, Azadeh Rezaei, Christopher A. Howard, Håvard Jostein Haugen, Judith Pape, Shosei Kishida, Michiko Kishida, Gavin Jell, Timothy R. Arnett, Stefano Fedele, Umber Cheema. Bioengineering the ameloblastoma tumour to study its effect on bone nodule formationScientific Reports 2021; 11(1) doi: 10.1038/s41598-021-03484-5
140
Hiba Aljayyousi, Sarah Sahloul, Ajymurat Orozaliev, Navajit Baban, Anh-Duc Van, Amani Al Nuairi, Pauline John, Azhar Zam, Piergiorgio Percipalle, Yong-Ak Song. A modular and reconfigurable microfluidic device for culturing spheroids under continuous perfusionAPL Bioengineering 2025; 9(3) doi: 10.1063/5.0262536
141
Andy Shar, Phillip Glass, Brandon Daul, Reza Moonesi Rad, Daeha Joung. Handbook of Neural Engineering2025;  doi: 10.1016/B978-0-323-95730-4.00010-X
142
Next-Generation Drug Delivery SystemsMethods in Pharmacology and Toxicology 2025;  doi: 10.1007/978-1-0716-4554-3_23
143
Jie Zhou, Zhiling Zhang, Shuang Fu, Lulu Xu, Yukang Wang, Zhihui Hu, Adam C. Midgley, Yufei Liu, Shufang Wang. sEV from 3D‐Cultured MSCs Engineered with miR‐27b‐3p for Treating TMJ‐OA by Suppressing OsteoclastogenesisSmall 2025; 21(46) doi: 10.1002/smll.202504482
144
Marna Eliana Sakalem, Maria Teresa De Sibio, Felipe Allan da Silva da Costa, Miriane de Oliveira. Historical evolution of spheroids and organoids, and possibilities of use in life sciences and medicineBiotechnology Journal 2021; 16(5) doi: 10.1002/biot.202000463
145
Selma Ben Hamouda, Maria Angélica Miglino, Gustavo de Sá Schiavo Matias, Guy Beauchamp, Jean-Pierre Lavoie. Asthmatic Bronchial Matrices Determine the Gene Expression and Behavior of Smooth Muscle Cells in a 3D Culture ModelFrontiers in Allergy 2021; 2 doi: 10.3389/falgy.2021.762026
146
Valentina Citi, Eugenia Piragine, Simone Brogi, Sara Ottino, Vincenzo Calderone. Development of In Vitro Corneal Models: Opportunity for Pharmacological TestingMethods and Protocols 2020; 3(4) doi: 10.3390/mps3040074
147
Hossein Abolhassani, Alireza Eskandari, Anita Saremi Poor, Ali Zarrabi, Behnoosh Khodadadi, Sara Karimifard, Hamidreza Sahrayi, Mahsa Bourbour, Mohammad Tavakkoli Yaraki. Nanobiotechnological approaches for breast cancer Management: Drug delivery systems and 3D In-Vitro modelsCoordination Chemistry Reviews 2024; 508 doi: 10.1016/j.ccr.2024.215754
148
Showkat Ul Nabi, Sofi Imtiyaz Ali, Muzafar Ahmad Rather, Wajid Mohammad Sheikh, Mehvish Altaf, Hemant Singh, Peerzada Tajamul Mumtaz, Narayan Chandra Mishra, Sheikh Uzma Nazir, Showkeen Muzamil Bashir. Organoids: A new approach in toxicity testing of nanotherapeuticsJournal of Applied Toxicology 2022; 42(1) doi: 10.1002/jat.4206
149
Sandy Eldridge, Arianna Scuteri, Eugenia Jones, Guido Cavaletti, Liang Guo, Elizabeth Glaze. Considerations for a Reliable In Vitro Model of Chemotherapy-Induced Peripheral NeuropathyToxics 2021; 9(11) doi: 10.3390/toxics9110300
150
Adem Polat, Dilek Göktürk. An alternative approach to tracing the volumic proliferation development of an entire tumor spheroid in 3D through a mini-Opto tomography platformMicron 2022; 152 doi: 10.1016/j.micron.2021.103173
151
Marko Milojević, Jan Rožanc, Jernej Vajda, Laura Činč Ćurić, Eva Paradiž, Andraž Stožer, Uroš Maver, Boštjan Vihar. In Vitro Disease Models of the Endocrine PancreasBiomedicines 2021; 9(10) doi: 10.3390/biomedicines9101415
152
Kah-Yin Lee, Hui-Xin Loh, Andrew Wan. Systems for Muscle Cell Differentiation: From Bioengineering to Future FoodMicromachines 2021; 13(1) doi: 10.3390/mi13010071
153
Ren Jie Phang, Nan Su, Anne M. Kong, Shiang Y. Lim, Jarmon G. Lees. Modelling diabetes-associated metabolic stress in human multicellular cardiac microtissuesJournal of Molecular and Cellular Cardiology 2025; 209 doi: 10.1016/j.yjmcc.2025.10.004
154
Saliha Erikci, Patricia Mundinger, Heike Boehm. Small Physical Cross-Linker Facilitates Hyaluronan HydrogelsMolecules 2020; 25(18) doi: 10.3390/molecules25184166
155
Pauline Maury, Erika Porcel, Adrien Mau, François Lux, Olivier Tillement, Pierre Mahou, Marie-Claire Schanne-Klein, Sandrine Lacombe. Rapid Evaluation of Novel Therapeutic Strategies Using a 3D Collagen-Based Tissue-Like ModelFrontiers in Bioengineering and Biotechnology 2021; 9 doi: 10.3389/fbioe.2021.574035
156
Giorgia Isinelli, Sharon Failla, Roberto Plebani, Alessandro Prete. Exploring oncology treatment strategies with tyrosine kinase inhibitors through advanced 3D models (Review)Medicine International 2024; 5(2) doi: 10.3892/mi.2024.212
157
Pancreatic Cancer: Basic Mechanisms and TherapiesAdvances in Cancer Research 2023; 159 doi: 10.1016/bs.acr.2023.02.010
158
Federica Foglietta, Loredana Serpe, Roberto Canaparo. The Effective Combination between 3D Cancer Models and Stimuli-Responsive Nanoscale Drug Delivery SystemsCells 2021; 10(12) doi: 10.3390/cells10123295
159
Daheui Choi, Kihak Gwon, Hye Jin Hong, Harihara Baskaran, Olalla Calvo-Lozano, Alan M. Gonzalez-Suarez, Kyungtae Park, Jose M. de Hoyos-Vega, Laura M. Lechuga, Jinkee Hong, Gulnaz Stybayeva, Alexander Revzin. Coating Bioactive Microcapsules with Tannic Acid Enhances the Phenotype of the Encapsulated Pluripotent Stem CellsACS Applied Materials & Interfaces 2022; 14(23) doi: 10.1021/acsami.2c06783
160
Kazim Kerim Moncal, Sena Yaman, Naside Gozde Durmus. Levitational 3D Bioassembly and Density‐Based Spatial Coding of LevitoidsAdvanced Functional Materials 2022; 32(50) doi: 10.1002/adfm.202204092
161
Samaneh Khazaei, Masoud Soleimani, Seyed Hossein Ahmadi Tafti, Rouhollah Mehdinavaz Aghdam, Zohreh Hojati. Improvement of Heart Function After Transplantation of Encapsulated Stem Cells Induced with miR-1/Myocd in Myocardial Infarction Model of RatCell Transplantation 2021; 30 doi: 10.1177/09636897211048786
162
Federico Pupilli, Andrea Ruffini, Massimiliano Dapporto, Marta Tavoni, Anna Tampieri, Simone Sprio. Design Strategies and Biomimetic Approaches for Calcium Phosphate Scaffolds in Bone Tissue RegenerationBiomimetics 2022; 7(3) doi: 10.3390/biomimetics7030112
163
Andressa Y. Fujiike, Celina Y. A. L. Lee, Fabiana S. T. Rodrigues, Larissa C. B. Oliveira, Aneli M. Barbosa-Dekker, Robert F. H. Dekker, Ilce M. S. Cólus, Juliana M. Serpeloni. Anticancer effects of carboxymethylated (1→3)(1→6)-β-D-glucan (botryosphaeran) on multicellular tumor spheroids of MCF-7 cells as a model of breast cancerJournal of Toxicology and Environmental Health, Part A 2022; 85(13) doi: 10.1080/15287394.2022.2048153
164
Sayumi Tahara, Fernanda Costas C. de Faria, Patricia Sarchet, Federica Calore, Joe Sharick, Jennifer L. Leight, Lucia Casadei, Raphael E. Pollock. Three dimensional models of dedifferentiated liposarcoma cell lines: scaffold-based and scaffold-free approachesHuman Cell 2023; 36(3) doi: 10.1007/s13577-023-00865-y
165
Jodi Graf, DeVonte Moore, Catherine L. Grimes, Catherine A. Fromen, April M. Kloxin. High-throughput bioprinted 3D cultures for probing host–pathogen interactions in bioinspired microenvironmentsRSC Applied Polymers 2026; 4(2) doi: 10.1039/D5LP00285K
166
Olga Trofimova, Ksenija Korotkaja, Dace Skrastina, Juris Jansons, Karina Spunde, Maria Isaguliants, Anna Zajakina. Alphavirus-Driven Interferon Gamma (IFNg) Expression Inhibits Tumor Growth in Orthotopic 4T1 Breast Cancer ModelVaccines 2021; 9(11) doi: 10.3390/vaccines9111247
167
Jiangtao Li, Xin Feng, Xiang Wei. Modeling hypertrophic cardiomyopathy with human cardiomyocytes derived from induced pluripotent stem cellsStem Cell Research & Therapy 2022; 13(1) doi: 10.1186/s13287-022-02905-0
168
Parmida Sadat Pezeshki, Nima Rezaei. Handbook of Cancer and Immunology2023;  doi: 10.1007/978-3-030-80962-1_206-1
169
Liang Zhu, Zhenfeng Wang, Huanming Xia, Hanry Yu. Design and Fabrication of the Vertical-Flow Bioreactor for Compaction Hepatocyte Culture in Drug Testing ApplicationBiosensors 2021; 11(5) doi: 10.3390/bios11050160
170
Hengameh Dortaj, Ali Mohammad Amani, Lobat Tayebi, Negar Azarpira, Mahtab Ghasemi Toudeshkchouei, Ashraf Hassanpour-Dehnavi, Neda Karami, Milad Abbasi, Atefeh Najafian-Najafabadi, Zeinab Zarei Behjani, Ahmad Vaez. Droplet-based microfluidics: an efficient high-throughput portable system for cell encapsulationJournal of Microencapsulation 2024; 41(6) doi: 10.1080/02652048.2024.2382744
171
Chloé Muzard, Johanne Seguin, Jonathan Bonnefoy, Nahla Salkini, Vincent Serra, Khair Alhareth, Katia Lemdani, Nathalie Mignet. Pre-clinical evaluation of mRNA-lipid nanoparticles’ potency and toxicity: current practices and future directionsIn vitro models 2025; 4(3-4) doi: 10.1007/s44164-025-00096-5
172
Susmita Roy, Mehnaz Parveen, Asis Bala, Debjeet Sur. The 3C (Cell Culture, Computer Simulation, Clinical Trial) Solution for Optimizing the 3R (Replace, Reduction, Refine) Framework during Preclinical Research Involving Laboratory AnimalsACS Pharmacology & Translational Science 2025; 8(5) doi: 10.1021/acsptsci.4c00661
173
Yoojin Seo, Min-Jung Kang, Hyung-Sik Kim. Strategies to Potentiate Paracrine Therapeutic Efficacy of Mesenchymal Stem Cells in Inflammatory DiseasesInternational Journal of Molecular Sciences 2021; 22(7) doi: 10.3390/ijms22073397
174
Laura Lacerda Coelho, Matheus Menezes Vianna, Debora Moraes da Silva, Beatriz Matheus de Souza Gonzaga, Roberto Rodrigues Ferreira, Ana Carolina Monteiro, Adriana Cesar Bonomo, Pedro Paulo de Abreu Manso, Marcelo Alex de Carvalho, Fernando Regla Vargas, Luciana Ribeiro Garzoni. Spheroid Model of Mammary Tumor Cells: Epithelial–Mesenchymal Transition and Doxorubicin ResponseBiology 2024; 13(7) doi: 10.3390/biology13070463
175
Irmak Ayvaz, Dilara Sunay, Ece Sariyar, Esra Erdal, Zeynep Firtina Karagonlar. Three-Dimensional Cell Culture Models of Hepatocellular Carcinoma — a ReviewJournal of Gastrointestinal Cancer 2021; 52(4) doi: 10.1007/s12029-021-00772-1
176
Elham Afzali, Touba Eslaminejad, Seyede Elmira Yazdi Rouholamini, Mariam Shahrokhi-Farjah, Mehdi Ansari. Cytotoxicity Effects of Curcumin Loaded on Chitosan Alginate Nanospheres on the KMBC-10 Spheroids Cell LineInternational Journal of Nanomedicine 2021;  doi: 10.2147/IJN.S251056
177
Annachiara Dozzo, Krishnakumar Chullipalliyalil, Michael McAuliffe, Caitriona M. O’Driscoll, Katie B. Ryan. Nano-Hydroxyapatite/PLGA Mixed Scaffolds as a Tool for Drug Development and to Study Metastatic Prostate Cancer in the BonePharmaceutics 2023; 15(1) doi: 10.3390/pharmaceutics15010242
178
Thomas A Bos, Elizaveta Polyakova, Janine Maria van Gils, Antoine AF de Vries, Marie-José Goumans, Christian Freund, Marco C DeRuiter, Monique RM Jongbloed. A systematic review and embryological perspective of pluripotent stem cell-derived autonomic postganglionic neuron differentiation for human disease modelingeLife 2025; 14 doi: 10.7554/eLife.103728
179
Seung Yeon Lee, Jin Woo Lee. 3D Spheroid Cultures of Stem Cells and Exosome Applications for Cartilage RepairLife 2022; 12(7) doi: 10.3390/life12070939
180
Vidur Raj, Chennupati Jagadish, Vini Gautam. Understanding, engineering, and modulating the growth of neural networks: An interdisciplinary approachBiophysics Reviews 2021; 2(2) doi: 10.1063/5.0043014
181
Reza Bayat Mokhtari, Manpreet Sambi, Bessi Qorri, Narges Baluch, Neda Ashayeri, Sushil Kumar, Hai-Ling Margaret Cheng, Herman Yeger, Bikul Das, Myron R. Szewczuk. The Next-Generation of Combination Cancer Immunotherapy: Epigenetic Immunomodulators Transmogrify Immune Training to Enhance ImmunotherapyCancers 2021; 13(14) doi: 10.3390/cancers13143596
182
Zin Zin Ei, Supaporn Barrameesangpet, Pithi Chanvorachote. Exploration of Aloe vera, Centella asiatica, Green Tea, and Pueraria mirifica Extracts in Modulating Stem Cell-Like Properties for Hair Rejuvenation Through β-Catenin Stabilization and Activation of the Akt Signaling Cascade in Human Dermal Papilla CellsNatural Product Communications 2025; 20(2) doi: 10.1177/1934578X251320146
183
Liezaan van der Merwe, Hanna Svitina, Clarissa Willers, Krzysztof Wrzesinski, Chrisna Gouws. A novel NCI‐H69V small cell lung cancer functional mini‐tumor model for future treatment screening applicationsBiotechnology Progress 2022; 38(4) doi: 10.1002/btpr.3253
184
Justyna Sośniak, Jolanta Opiela. 3D Cell Culture Technology – A New Insight Into in Vitro Research – A ReviewAnnals of Animal Science 2021; 21(4) doi: 10.2478/aoas-2021-0039
185
Shamapto Guha Anthon, Karolina Papera Valente. Vascularization Strategies in 3D Cell Culture Models: From Scaffold-Free Models to 3D BioprintingInternational Journal of Molecular Sciences 2022; 23(23) doi: 10.3390/ijms232314582
186
Fabrizio Fontana, Monica Marzagalli, Michele Sommariva, Nicoletta Gagliano, Patrizia Limonta. In Vitro 3D Cultures to Model the Tumor MicroenvironmentCancers 2021; 13(12) doi: 10.3390/cancers13122970
187
Hualong Zhao, Siyuan Wang, Yilu Zhou, Ayse Ertay, Philip T. F. Williamson, Rob M. Ewing, Xinhui Tang, Jialian Wang, Yihua Wang. Integrated analysis reveals effects of bioactive ingredients from Limonium Sinense (Girard) Kuntze on hypoxia-inducible factor (HIF) activationFrontiers in Plant Science 2022; 13 doi: 10.3389/fpls.2022.994036
188
Verena Staedtke, Piotr Topilko, Lu Q. Le, Kevin Grimes, David A. Largaespada, Ross L. Cagan, Matthew R. Steensma, Anat Stemmer-Rachamimov, Jaishri O. Blakeley, Steven D. Rhodes, Ina Ly, Carlos G. Romo, Sang Y. Lee, Eduard Serra. Existing and Developing Preclinical Models for Neurofibromatosis Type 1−Related Cutaneous NeurofibromasJournal of Investigative Dermatology 2023; 143(8) doi: 10.1016/j.jid.2023.01.042
189
Benjamin Allcock, Wenbin Wei, Kirsty Goncalves, Henry Hoyle, Alisha Robert, Rebecca Quelch-Cliffe, Adam Hayward, Jim Cooper, Stefan Przyborski. Impact of the Physical Cellular Microenvironment on the Structure and Function of a Model Hepatocyte Cell Line for Drug Toxicity ApplicationsCells 2023; 12(19) doi: 10.3390/cells12192408
190
Fahimeh Varzideh, Pasquale Mone, Gaetano Santulli. Bioengineering Strategies to Create 3D Cardiac Constructs from Human Induced Pluripotent Stem CellsBioengineering 2022; 9(4) doi: 10.3390/bioengineering9040168
191
Alissar Monzer, Kevork Wakimian, Farah Ballout, Samar Al Bitar, Amani Yehya, Mariam Kanso, Nour Saheb, Ayman Tawil, Samer Doughan, Maher Hussein, Deborah Mukherji, Walid Faraj, Hala Gali-Muhtasib, Wassim Abou-Kheir. Novel therapeutic diiminoquinone exhibits anticancer effects on human colorectal cancer cells in two-dimensional and three-dimensional <i>in vitro</i> modelsWorld Journal of Gastroenterology 2022; 28(33): 4787-4811 doi: 10.3748/wjg.v28.i33.4787
192
Sonja Holme, Stephen M. Richardson, Jordi Bella, Christian Pinali. Hydrogels for Cardiac Tissue Regeneration: Current and Future DevelopmentsInternational Journal of Molecular Sciences 2025; 26(5) doi: 10.3390/ijms26052309
193
Joannah R. Fergusson, Jacqueline H.Y. Siu, Nitya Gupta, Edward Jenkins, Eloise Nee, Sören Reinke, Tamara Ströbel, Ananya Bhalla, Shyami M. Kandage, Thomas Courant, Sarah Hill, Moustafa Attar, Michael L. Dustin, Alex Gordon-Weeks, Mark Coles, Calliope A. Dendrou, Anita Milicic. Ex vivo model of functioning human lymph node reveals role for innate lymphocytes and stroma in response to vaccine adjuvantCell Reports 2025; 44(7) doi: 10.1016/j.celrep.2025.115938
194
Charles-Henri Wassmer, Kevin Bellofatto, Lisa Perez, Vanessa Lavallard, David Cottet-Dumoulin, Sanda Ljubicic, Géraldine Parnaud, Domenico Bosco, Ekaterine Berishvili, Fanny Lebreton. Engineering of Primary Pancreatic Islet Cell Spheroids for Three-dimensional Culture or Transplantation: A Methodological Comparative StudyCell Transplantation 2020; 29 doi: 10.1177/0963689720937292
195
Diana P. Saraiva, Ana T. Matias, Sofia Braga, António Jacinto, M. Guadalupe Cabral. Establishment of a 3D Co-culture With MDA-MB-231 Breast Cancer Cell Line and Patient-Derived Immune Cells for Application in the Development of ImmunotherapiesFrontiers in Oncology 2020; 10 doi: 10.3389/fonc.2020.01543
196
Sameh M. Farouk, Asmaa F. Khafaga, Ahmed M. Abdellatif. Bladder cancer: therapeutic challenges and role of 3D cell culture systems in the screening of novel cancer therapeuticsCancer Cell International 2023; 23(1) doi: 10.1186/s12935-023-03069-4
197
Zhangning Fu, Yifan Zhang, Xiaodong Geng, Kun Chi, Chao Liu, Chengcheng Song, Guangyan Cai, Xiangmei Chen, Quan Hong. Optimization strategies of mesenchymal stem cell-based therapy for acute kidney injuryStem Cell Research & Therapy 2023; 14(1) doi: 10.1186/s13287-023-03351-2
198
Vaishali Aggarwal, Oshin Miranda, Paul A. Johnston, Shilpa Sant. Three dimensional engineered models to study hypoxia biology in breast cancerCancer Letters 2020; 490 doi: 10.1016/j.canlet.2020.05.030
199
Marina Guimarães Gobbo, Gláucia Maria de Mendonça Fernandes, Rafael Fernandes-Ferreira, Lennon Pereira Caires, Heloisa Cristina Caldas, Débora Aparecida Pires de Campos Zuccari, Newton Antonio Bordin-Junior, Giovana Aparecida Gonçalves Vidotti, Doroteia Rossi Silva Souza. Evaluation of doxorubicin in three-dimensional culture of breast cancer cells and the response in PI3K/AKT/PTEN signaling pathways: a pilot studyWomen & Health 2022; 62(6) doi: 10.1080/03630242.2022.2085842
200
Martin Garcia-Gonzalez, Karen Ivana Caro-Felix, Diana Priscila Bonilla-Ruelas, Alan Maximiliano Cortes-Limon, Ana Cecilia Luque-Badillo, Mauricio Andrés Salinas-Santander, Danielle Annette Orozco-Nunnelly, Juan Pablo Aguilar-Aleman, Claudia Lisette Charles-Niño, Clara Patricia Rios-Ibarra. A PBL strategy for incorporating 3D cell culture into the classrooms of undergraduate biotechnology engineering studentsResearch in Science & Technological Education 2025; 43(4) doi: 10.1080/02635143.2024.2423077
201
Alessandra Girotti, Sara Escalera-Anzola, Irene Alonso-Sampedro, Juan González-Valdivieso, Francisco Javier Arias. Aptamer-Functionalized Natural Protein-Based Polymers as Innovative BiomaterialsPharmaceutics 2020; 12(11) doi: 10.3390/pharmaceutics12111115
202
Ella Itzhaki, Elad Hadad, Neta Moskovits, Salomon M. Stemmer, Shlomo Margel. Tumor-Targeted Fluorescent Proteinoid Nanocapsules Encapsulating Synergistic Drugs for Personalized Cancer TherapyPharmaceuticals 2021; 14(7) doi: 10.3390/ph14070648
203
Vahid Mansouri, Nima Beheshtizadeh, Maliheh Gharibshahian, Leila Sabouri, Mohammad Varzandeh, Nima Rezaei. Recent advances in regenerative medicine strategies for cancer treatmentBiomedicine & Pharmacotherapy 2021; 141 doi: 10.1016/j.biopha.2021.111875
204
Kailash Ahirwar, Ankit Kumar, Nidhi Srivastava, Shubhini A. Saraf, Rahul Shukla. Harnessing the potential of nanoengineered siRNAs carriers for target responsive glioma therapy: Recent progress and future opportunitiesInternational Journal of Biological Macromolecules 2024; 266 doi: 10.1016/j.ijbiomac.2024.131048
205
Colin H. Quinn, Andee M. Beierle, Elizabeth A. Beierle. Artificial Tumor Microenvironments in NeuroblastomaCancers 2021; 13(7) doi: 10.3390/cancers13071629
206
Hung-Jin Huang, Yu-Hsuan Lee, Yung-Ho Hsu, Chia-Te Liao, Yuh-Feng Lin, Hui-Wen Chiu. Current Strategies in Assessment of Nanotoxicity: Alternatives to In Vivo Animal TestingInternational Journal of Molecular Sciences 2021; 22(8) doi: 10.3390/ijms22084216
207
Ahmed Yaqinuddin, Muhammad Faisal Ikram, Ayesha Rahman Ambia, Raghad Alaujan, Junaid Kashir. 3D Models as an Adjunct for Models in Studying Alzheimer's DiseaseJournal of Health and Allied Sciences NU 2022; 12(02) doi: 10.1055/s-0041-1731864
208
Andrew M. K. Law, Laura Rodriguez de la Fuente, Thomas J. Grundy, Guocheng Fang, Fatima Valdes-Mora, David Gallego-Ortega. Advancements in 3D Cell Culture Systems for Personalizing Anti-Cancer TherapiesFrontiers in Oncology 2021; 11 doi: 10.3389/fonc.2021.782766
209
Raven El Khoury, Naveen Nagiah, Joel A. Mudloff, Vikram Thakur, Munmun Chattopadhyay, Binata Joddar. 3D Bioprinted Spheroidal Droplets for Engineering the Heterocellular Coupling between Cardiomyocytes and Cardiac FibroblastsCyborg and Bionic Systems 2021; 2021 doi: 10.34133/2021/9864212
210
Hwa-Yong Lee, Jin Woo Lee. Spheroid-Exosome-Based Bioprinting Technology in Regenerative MedicineJournal of Functional Biomaterials 2024; 15(11) doi: 10.3390/jfb15110345
211
Yaping Zhang, Huasu Zhu, Linghong Liu, Huixian Ma, Qing Shi, Dong Li, Xiuli Ju. Three‐dimensional culture of rat ovarian granulosa cells shows increased SPP1 and FGF7 expression through the PI3K/Akt pathwayCell Biology International 2023; 47(5) doi: 10.1002/cbin.11998
212
Karolina M. Lonkwic, Radosław Zajdel, Krzysztof Kaczka. Unlocking the Potential of Spheroids in Personalized Medicine: A Systematic Review of Seeding MethodologiesInternational Journal of Molecular Sciences 2025; 26(13) doi: 10.3390/ijms26136478
213
Guya Diletta Marconi, Cristina Porcheri, Oriana Trubiani, Thimios A. Mitsiadis. Three-Dimensional Culture Systems for Dissecting Notch Signalling in Health and DiseaseInternational Journal of Molecular Sciences 2021; 22(22) doi: 10.3390/ijms222212473
214
Ankita Borah, D. Sakthi Kumar. Biomedical Product and Materials Evaluation2022;  doi: 10.1016/B978-0-12-823966-7.00003-7
215
Daniela Rodrigues, Bram Herpers, Sofia Ferreira, Heeseung Jo, Ciarán Fisher, Luke Coyle, Seung-Wook Chung, Jos C. S. Kleinjans, Danyel G. J. Jennen, Theo M. de Kok. A Transcriptomic Approach to Elucidate the Mechanisms of Gefitinib-Induced Toxicity in Healthy Human Intestinal OrganoidsInternational Journal of Molecular Sciences 2022; 23(4) doi: 10.3390/ijms23042213
216
Deogil Kim, Min-Ju Lee, Yoshie Arai, Jinsung Ahn, Gun Woo Lee, Soo-Hong Lee. Ultrasound-triggered three dimensional hyaluronic acid hydrogel promotes in vitro and in vivo reprogramming into induced pluripotent stem cellsBioactive Materials 2024; 38 doi: 10.1016/j.bioactmat.2024.05.011
217
Xuan Hao Tan, Ling Liu, Alexander Mitryashkin, Yunyun Wang, James Cho Hong Goh. Silk Fibroin as a Bioink – A Thematic Review of Functionalization Strategies for Bioprinting ApplicationsACS Biomaterials Science & Engineering 2022; 8(8) doi: 10.1021/acsbiomaterials.2c00313
218
Daniela Mathes, Letícia Bueno Macedo, Taís Baldissera Pieta, Bianca Costa Maia, Oscar Endrigo Dorneles Rodrigues, Julliano Guerin Leal, Marcelo Wendt, Clarice Madalena Bueno Rolim, Montserrat Mitjans, Daniele Rubert Nogueira-Librelotto. Co-Delivery of an Innovative Organoselenium Compound and Paclitaxel by pH-Responsive PCL Nanoparticles to Synergistically Overcome Multidrug Resistance in CancerPharmaceutics 2024; 16(5) doi: 10.3390/pharmaceutics16050590
219
Andrea De Pieri, Benjamin D. Korman, Astrid Jüngel, Karin Wuertz‐Kozak. Engineering Advanced In Vitro Models of Systemic Sclerosis for Drug Discovery and DevelopmentAdvanced Biology 2021; 5(4) doi: 10.1002/adbi.202000168
220
Fatemeh Soleimanifar, Nazli Aghapur, Zeinab Rezaei-Kiasari, Hosein Mahboudi, Mohammad Kaabi, Reyhaneh Nassiri Mansour, Mousa Kehtari, Mohammadfoad Abazari, Seyed Ehsan Enderami, Hadi Hassannia. The generation of islet-like insulin-producing cells from Wharton's jelly-derived mesenchymal stem cells on the PES/fish gelatin scaffoldRegenerative Therapy 2024; 26 doi: 10.1016/j.reth.2024.05.019
221
Jacob Hodge, Aidyn Medina-Lopez, Christopher Neal, Heather Decker, Jennifer Robinson, Adam J. Mellott. Comparison of 3D culture systems on mesenchymal stem cell longevity, regenerative potential, and secretome productionRegenerative Medicine 2025; 20(10) doi: 10.1080/17460751.2025.2572177
222
Sofia I. Bär, Bernhard Biersack, Rainer Schobert. 3D cell cultures, as a surrogate for animal models, enhance the diagnostic value of preclinical in vitro investigations by adding information on the tumour microenvironment: a comparative study of new dual-mode HDAC inhibitorsInvestigational New Drugs 2022; 40(5) doi: 10.1007/s10637-022-01280-0
223
Qamar Abuhassan, Hamzeh J. Al-Ameer, Shahad Mohammed Dhiaa Younis, Jasur Rizaev, Makhfirat Kibriyeva, Rasim M. Salih, Mohamed Adil Jaber. Emerging nanoparticle approaches for early detection and therapeutic targeting of pancreatic cancerClinica Chimica Acta 2026; 590 doi: 10.1016/j.cca.2026.121102
224
Sarah Strauß, Maximilian Diemer, Vesna Bucan, Jörn W Kuhbier, Tomke Asendorf, Peter M Vogt, Frederik Schlottmann. Spider silk enhanced tissue engineering of cartilage tissue: Approach of a novel bioreactor model using adipose derived stromal cellsJournal of Applied Biomaterials & Functional Materials 2024; 22 doi: 10.1177/22808000241226656
225
Cristina Zivko, Tae‐Hun Hahm, Cay Tressler, Dalton Brown, Kristine Glunde, Vasiliki Mahairaki. Mass Spectrometry Imaging of Organoids to Improve Preclinical ResearchAdvanced Healthcare Materials 2024; 13(21) doi: 10.1002/adhm.202302499
226
Tae-Jun Min, Min Ji Kim, Kyung-Jung Kang, Yeoung Jo Jeoung, Se Heang Oh, Young-Joo Jang, Adam Ye. 3D Spheroid Formation Using BMP-Loaded Microparticles Enhances Odontoblastic Differentiation of Human Dental Pulp Stem CellsStem Cells International 2021; 2021 doi: 10.1155/2021/9326298
227
Priyanka Priyadarshani, Rebecca S. Schneider, Kejie Rui, Andrés J. García, Luke J. Mortensen. Prediction of Mesenchymal Stromal Cell Immune Suppression Using Live Imaging in a Three-Dimensional Microfluidic DeviceACS Biomaterials Science & Engineering 2026;  doi: 10.1021/acsbiomaterials.6c00109
228
Nora Bloise, Marialaura Giannaccari, Giuseppe Guagliano, Emanuela Peluso, Elisa Restivo, Silvia Strada, Cristina Volpini, Paola Petrini, Livia Visai. Growing Role of 3D In Vitro Cell Cultures in the Study of Cellular and Molecular Mechanisms: Short Focus on Breast Cancer, Endometriosis, Liver and Infectious DiseasesCells 2024; 13(12) doi: 10.3390/cells13121054
229
Zahra El-Schich. Digital Holographic Microscopy: A Noninvasive Method to Analyze the Formation of SpheroidsBioTechniques 2021; 71(6) doi: 10.2144/btn-2021-0062
230
Soon Lee, Eunmi Hong, Eunbi Jo, Z-Hun Kim, Kyung June Yim, Sung Hwan Woo, Yong-Soo Choi, Hyun-Jin Jang. Gossypol Induces Apoptosis of Human Pancreatic Cancer Cells via CHOP/Endoplasmic Reticulum Stress Signaling PathwayJournal of Microbiology and Biotechnology 2022; 32(5) doi: 10.4014/jmb.2110.10019
231
Kavitha Govarthanan, Piyush Kumar Gupta, Binita E. Zipporah, Vineeta Sharma, M. Rajasundari, Khawaja Husnain Haider. Handbook of Stem Cell Therapy2022;  doi: 10.1007/978-981-16-6016-0_43-1
232
Ruiling Xu, Ruiqi Chen, Chao Tu, Xiaofeng Gong, Zhongyue Liu, Lin Mei, Xiaolei Ren, Zhihong Li. 3D Models of Sarcomas: The Next-generation Tool for Personalized MedicinePhenomics 2024; 4(2) doi: 10.1007/s43657-023-00111-3
233
Mahfoozur Rahman, Ankit Sahoo, Waleed H. Almalki, Salem Salman Almujri, Alhussain Aodah, Abdulrahman A. Alnofei, Abdulrahman Alhamyani. Three-dimensional cell culture: Future scope in cancer vaccine developmentDrug Discovery Today 2024; 29(9) doi: 10.1016/j.drudis.2024.104114
234
Kensey Bergdorf, Joshua A. Bauer, David Westover, Courtney Phifer, Barbara Murphy, Darren R. Tyson, Ethan Lee, Vivian L. Weiss. Utilizing Three-Dimensional Culture Methods to Improve High-Throughput Drug Screening in Anaplastic Thyroid CarcinomaCancers 2022; 14(8) doi: 10.3390/cancers14081855
235
Nkune Williams Nkune, Heidi Abrahamse. The Efficacy of Zinc Phthalocyanine Nanoconjugate on Melanoma Cells Grown as Three-Dimensional Multicellular Tumour SpheroidsPharmaceutics 2023; 15(9) doi: 10.3390/pharmaceutics15092264
236
Sudeep Banerjee, Hyunho Yoon, Stephanie Ting, Chih-Min Tang, Mayra Yebra, Alexander T. Wenzel, Huwate Yeerna, Jill P. Mesirov, Robert J. Wechsler-Reya, Pablo Tamayo, Jason K. Sicklick. KITlow Cells Mediate Imatinib Resistance in Gastrointestinal Stromal TumorMolecular Cancer Therapeutics 2021; 20(10) doi: 10.1158/1535-7163.MCT-20-0973
237
Marianne E. Prévôt, Senay Ustunel, Guillaume Freychet, Caitlyn R. Webb, Mikhail Zhernenkov, Ron Pindak, Robert J. Clements, Elda Hegmann. Physical Models from Physical Templates Using Biocompatible Liquid Crystal Elastomers as Morphologically Programmable Inks For 3D PrintingMacromolecular Bioscience 2023; 23(3) doi: 10.1002/mabi.202200343
238
Anastasiya N. Shishparenok, Anna Yu. Alekseeva, Anna G. Erokhina, Peter S. Timashev, Yuri M. Efremov, Igor D. Zlotnikov, Elena V. Kudryashova, Dmitry D. Zhdanov. Bacterial cellulose composite hydrogel for 3D cell cultivation and anticancer drug testingBiotechnology and Bioprocess Engineering 2026;  doi: 10.1007/s12257-026-00272-8
239
Atena Malakpour-Permlid, Stina Oredsson. A novel 3D polycaprolactone high-throughput system for evaluation of toxicity in normoxia and hypoxiaToxicology Reports 2021; 8 doi: 10.1016/j.toxrep.2021.03.015
240
Ilias Nikolits, Sara Radwan, Falk Liebner, Wolf Dietrich, Dominik Egger, Farhad Chariyev-Prinz, Cornelia Kasper. Hydrogels from TEMPO-Oxidized Nanofibrillated Cellulose Support In Vitro Cultivation of Encapsulated Human Mesenchymal Stem CellsACS Applied Bio Materials 2023; 6(2) doi: 10.1021/acsabm.2c00854
241
Nkune Williams Nkune, Heidi Abrahamse, Lothar D. Lilge, Zhiwei Huang. The phototoxic effect of zinc phthalocyanine on melanoma cells grown as a monolayer and three-dimensional multicellular spheroidsTranslational Biophotonics: Diagnostics and Therapeutics III 2023;  doi: 10.1117/12.2675718
242
Tania Limongi, Francesco Guzzi, Elvira Parrotta, Patrizio Candeloro, Stefania Scalise, Valeria Lucchino, Francesco Gentile, Luca Tirinato, Maria Laura Coluccio, Bruno Torre, Marco Allione, Monica Marini, Francesca Susa, Enzo Di Fabrizio, Giovanni Cuda, Gerardo Perozziello. Microfluidics for 3D Cell and Tissue Cultures: Microfabricative and Ethical Aspects UpdatesCells 2022; 11(10) doi: 10.3390/cells11101699
243
Bianca Galateanu, Ariana Hudita, Elena Iuliana Biru, Horia Iovu, Catalin Zaharia, Eliza Simsensohn, Marieta Costache, Razvan-Cosmin Petca, Viorel Jinga. Applications of Polymers for Organ-on-Chip Technology in UrologyPolymers 2022; 14(9) doi: 10.3390/polym14091668
244
Tengfei Zhou, Mingdeng Rong, Zijie Wang, Hongxing Chu, Chuying Chen, Jiayi Zhang, Zhihui Tian. Conditioned medium derived from 3D tooth germs: A novel cocktail for stem cell priming and early in vivo pulp regenerationCell Proliferation 2021; 54(11) doi: 10.1111/cpr.13129
245
C. E. Staicu, F. Jipa, I. Porosnicu, A. Bran, E. Stancu, C. Dobrea, B. M. Radu, E. Axente, I. Tiseanu, F. Sima, K. Sugioka. Glass lab-on-a-chip platform fabricated by picosecond laser for testing tumor cells exposed to X-ray radiationApplied Physics A 2022; 128(9) doi: 10.1007/s00339-022-05915-0
246
Darius Čiužas, Edvinas Krugly, Vilma Petrikaitė. The fabrication method impacts biological properties of microfibrous three-dimensional in vitro cell culture scaffolds and their applications in drug screeningMaterials Today Communications 2024; 39 doi: 10.1016/j.mtcomm.2024.108707
247
Thorsten Steinberg, Martin Philipp Dieterle, Pascal Tomakidi. Molecular Research on Oral Diseases and Related Biomaterials: A Journey from Oral Cell Models to Advanced Regenerative PerspectivesInternational Journal of Molecular Sciences 2022; 23(9) doi: 10.3390/ijms23095288
248
Raghu Ram Achar, Archer Ann Catherine, Sanya Hazel Soans, Shraman Kumar Bohra, Manjunatha H Boregowda, SubbaRao V. Madhunapantula, Asha Srinivasan. Microfluidics and Multi Organs on Chip2022;  doi: 10.1007/978-981-19-1379-2_14
249
Dilek Bahar, Muhammed Tilahun Muhammed, Senem Akkoc. In vitro cytotoxic activity, cells staining, DFT computation, docking, and MD simulation of silver N-heterocyclic carbene complexesJournal of the Indian Chemical Society 2025; 102(3) doi: 10.1016/j.jics.2025.101602
250
Mona Mansouri, Nic D. Leipzig. Advances in removing mass transport limitations for more physiologically relevant in vitro 3D cell constructsBiophysics Reviews 2021; 2(2) doi: 10.1063/5.0048837
251
Rongqi Huang, Shuai Li, Chao Tian, Peng Zhou, Huifang Zhao, Wei Xie, Jie Xiao, Ling Wang, Jean de Dieu Habimana, Zuoxian Lin, Yuchen Yang, Na Cheng, Zhiyuan Li. Thermal stress involved in TRPV2 promotes tumorigenesis through the pathways of HSP70/27 and PI3K/Akt/mTOR in esophageal squamous cell carcinomaBritish Journal of Cancer 2022; 127(8) doi: 10.1038/s41416-022-01896-2
252
Seo Hyung Moon, Tae Yoon Park, Hyung Joon Cha, Yun Jung Yang. Photo-/thermo-responsive bioink for improved printability in extrusion-based bioprintingMaterials Today Bio 2024; 25 doi: 10.1016/j.mtbio.2024.100973
253
Nabanita Mukherjee, Karoline A. Lambert, David A. Norris, Yiqun G. Shellman. MelanomaMethods in Molecular Biology 2021; 2265 doi: 10.1007/978-1-0716-1205-7_14
254
Sara Tirendi, Sergio Claudio Saccà, Stefania Vernazza, Carlo Traverso, Anna Maria Bassi, Alberto Izzotti. A 3D Model of Human Trabecular Meshwork for the Research Study of GlaucomaFrontiers in Neurology 2020; 11 doi: 10.3389/fneur.2020.591776
255
Devika Tripathi, Vikas Shukla, Jagannath Sahoo, Dinesh Kumar Sharma, Tuhin Shukla. Targeted Cancer Therapy in Biomedical EngineeringBiological and Medical Physics, Biomedical Engineering 2023;  doi: 10.1007/978-981-19-9786-0_8
256
Jacob G. Hodge, Jennifer L. Robinson, Adam J. Mellott. Mesenchymal Stem Cell Extracellular Vesicles from Tissue-Mimetic System Enhance Epidermal Regeneration via Formation of Migratory Cell SheetsTissue Engineering and Regenerative Medicine 2023; 20(6) doi: 10.1007/s13770-023-00565-6
257
Masoumeh Keshavarz, Navid Ahmadi Nasab. Principles of Human Organs-on-Chips2023;  doi: 10.1016/B978-0-12-823536-2.00008-0
258
Jiang Wu, Kai Kang, Siqi Liu, Yaodan Ma, Meng Yu, Xin Zhao. Recent Progress of In Vitro 3D Culture of Male Germ Stem CellsJournal of Functional Biomaterials 2023; 14(11) doi: 10.3390/jfb14110543
259
Beatriz Xavier Soares, Cláudia C. Miranda, Tiago G. Fernandes. Systems bioengineering approaches for developmental toxicologyComputational and Structural Biotechnology Journal 2023; 21 doi: 10.1016/j.csbj.2023.06.005
260
Nkune Williams Nkune, Heidi Abrahamse. The phototoxic effect of a gold-antibody-based nanocarrier of phthalocyanine on melanoma monolayers and tumour spheroidsRSC Advances 2024; 14(27) doi: 10.1039/D4RA03858D
261
Yunan Yuan, Zhimin Luo, Jie Chen, Chaoliang He, Kai Hao, Huayu Tian. Constructing thermoresponsive PNIPAM-based microcarriers for cell culture and enzyme-free cell harvestingChinese Chemical Letters 2024; 35(7) doi: 10.1016/j.cclet.2024.109549
262
Shasank Sekhar Swain, Sanjeeb K. Sahoo. 3D Bioprinting in Cancer Applications2025;  doi: 10.1016/B978-0-443-26518-1.00006-9
263
Ertan Kanbur, Ahmet Tarık Baykal, Azmi Yerlikaya. Molecular analysis of cell survival and death pathways in the proteasome inhibitor bortezomib-resistant PC3 prostate cancer cell lineMedical Oncology 2021; 38(9) doi: 10.1007/s12032-021-01563-1
264
Chirag Varshney, Brijesh Kumar, Swapnil C. Kamble. New Horizons in Natural Compound Research2023;  doi: 10.1016/B978-0-443-15232-0.00009-6
265
Xabier Morales, Iván Cortés-Domínguez, Carlos Ortiz-de-Solorzano. Modeling the Mechanobiology of Cancer Cell Migration Using 3D Biomimetic HydrogelsGels 2021; 7(1) doi: 10.3390/gels7010017
266
Kavitha Govarthanan, Piyush Kumar Gupta, Binita E. Zipporah, Vineeta Sharma, M. Rajasundari, Khawaja Husnain Haider. Handbook of Stem Cell Therapy2022;  doi: 10.1007/978-981-19-2655-6_43
267
Isabel Matos Oliveira, Diogo Castro Fernandes, Fátima Raquel Maia, Raphael Faustino Canadas, Rui Luís Reis, Joaquim Miguel Oliveira. Bioengineered Nanoparticles Loaded-Hydrogels to Target TNF Alpha in Inflammatory DiseasesPharmaceutics 2021; 13(8) doi: 10.3390/pharmaceutics13081111
268
Inês Mó, Ivo J Sabino, Duarte de Melo-Diogo, Rita Lima-Sousa, Cátia G Alves, Ilídio J Correia. The Importance of Spheroids in Analyzing Nanomedicine EfficacyNanomedicine 2020; 15(15) doi: 10.2217/nnm-2020-0054
269
Shaojun Gong, Leili Shahriyari. A Review of Stochastic and Deterministic Modeling of Stem Cell DynamicsCurrent Stem Cell Reports 2023; 9(1) doi: 10.1007/s40778-023-00225-4
270
Hans Kleine‐Brüggeney, Robert Weingarten, Franziska Schulze Bockeloh, Christoph Engwer, Vincent Fartmann, Jan Schäfer, Maryam Rezaei, Sebastian Bühren. A Macro‐to‐Micro Interface for Performing Comprehensive Microfluidic Cell Culture AssaysAdvanced Materials Interfaces 2021; 8(21) doi: 10.1002/admi.202100785
271
Nabi Mousavi. Characterization of in vitro 3D culturesAPMIS 2021; 129(S142) doi: 10.1111/apm.13168
272
Elizabeth Dunn, Kenny Chitcholtan, Peter Sykes, Ashley Garrill. The Anti-Proliferative Effect of PI3K/mTOR and ERK Inhibition in Monolayer and Three-Dimensional Ovarian Cancer Cell ModelsCancers 2022; 14(2) doi: 10.3390/cancers14020395
273
Merve Demir, Selen Öztürk, Gülşen Bayrak, Işık Perçin, Aysun Kılıç Süloğlu. PHEMA-based cryogels as 3D placental scaffoldsProcess Biochemistry 2023; 133 doi: 10.1016/j.procbio.2023.08.005
274
Nokuphila Winifred Nompumelelo Simelane, Heidi Abrahamse. Zinc phthalocyanine loaded- antibody functionalized nanoparticles enhance photodynamic therapy in monolayer (2-D) and multicellular tumour spheroid (3-D) cell culturesFrontiers in Molecular Biosciences 2024; 10 doi: 10.3389/fmolb.2023.1340212
275
Madhu Rani, Annu Devi, Shashi Prakash Singh, Rashmi Kumari, Anil Kumar. Animal Cell Culture: Principles and PracticeTechniques in Life Science and Biomedicine for the Non-Expert 2023;  doi: 10.1007/978-3-031-19485-6_14
276
Jose G. Munguia-Lopez, Sangeeth Pillai, Yuli Zhang, Jacqueline Kort-Mascort, Zhiyue Zhu, Joseph M. Kinsella, Simon D. Tran. Hydrogels for Tissue Engineering and Regenerative Medicine2024;  doi: 10.1016/B978-0-12-823948-3.00038-5
277
Shujun Liang, Qingbo Wang, Chunlin Xu, Jessica M. Rosenholm, Xiaoju Wang. Photocurable cellulose nanofibers and their copolymers with polyacrylamide as microgels to support 3D cell cultivationNanoscale 2025; 17(23) doi: 10.1039/D5NR00583C
278
Christina Cortez‐Jugo, Ewa Czuba‐Wojnilowicz, Abigail Tan, Frank Caruso. A Focus on “Bio” in Bio–Nanoscience: The Impact of Biological Factors on Nanomaterial InteractionsAdvanced Healthcare Materials 2021; 10(16) doi: 10.1002/adhm.202100574
279
Florian Keller, Roman Bruch, Richard Schneider, Julia Meier-Hubberten, Mathias Hafner, Rüdiger Rudolf. A Scaffold-Free 3-D Co-Culture Mimics the Major Features of the Reverse Warburg Effect In VitroCells 2020; 9(8) doi: 10.3390/cells9081900
280
Abirami M. Padmanaban, Kumar Ganesan, Kunka Mohanram Ramkumar. A Co-Culture System for Studying Cellular Interactions in Vascular DiseaseBioengineering 2024; 11(11) doi: 10.3390/bioengineering11111090
281
Dennis Ma, Grace A. Hernandez, Austin E. Y. T. Lefebvre, Hamad Alshetaiwi, Kerrigan Blake, Kushal R. Dave, Maha Rauf, Justice W. Williams, Ryan T. Davis, Katrina T. Evans, Aaron Longworth, Madona Y. G. Masoud, Regis Lee, Robert A. Edwards, Michelle A. Digman, Kai Kessenbrock, Devon A. Lawson. Patient-derived xenograft culture-transplant system for investigation of human breast cancer metastasisCommunications Biology 2021; 4(1) doi: 10.1038/s42003-021-02596-y
282
Seong‐Eun Kim, Suji Yun, Junsang Doh, Hong Nam Kim. Imaging‐Based Efficacy Evaluation of Cancer Immunotherapy in Engineered Tumor Platforms and Tumor OrganoidsAdvanced Healthcare Materials 2024; 13(27) doi: 10.1002/adhm.202400475
283
Wen Xue, Donghee Lee, Yunfan Kong, Mitchell Kuss, Ying Huang, Taesung Kim, Soonkyu Chung, Andrew T. Dudley, Seung‐Hyun Ro, Bin Duan. A Facile Strategy for the Fabrication of Cell‐Laden Porous Alginate Hydrogels based on Two‐Phase Aqueous EmulsionsAdvanced Functional Materials 2023; 33(35) doi: 10.1002/adfm.202214129
284
Ju-Hwan Kim, Hyun-Jin Lee, Hye-Jung Song, Jun-Beom Park. Impact of 17β-Estradiol on the Shape, Survival, Osteogenic Transformation, and mRNA Expression of Gingiva-Derived Stem Cell SpheroidsMedicina 2023; 60(1) doi: 10.3390/medicina60010060
285
Yu Wang, Dorit Siebzehnrubl, Michael Weller, Tobias Weiss, Florian A. Siebzehnrubl, Ben Newland. Vortioxetine: A Potential Drug for Repurposing for Glioblastoma Treatment via a Microsphere Local Delivery SystemACS Biomaterials Science & Engineering 2025; 11(4) doi: 10.1021/acsbiomaterials.5c00068
286
Kaiwen Zheng, Yiyang Ma, Cheng Chiu, Mengxin Xue, Changqing Zhang, Dajiang Du. Enhanced articular cartilage regeneration using costal chondrocyte-derived scaffold-free tissue engineered constructs with ascorbic acid treatmentJournal of Orthopaedic Translation 2024; 45 doi: 10.1016/j.jot.2024.02.005
287
Marina Goryunova, Yiran He, Carson Karakis, Elizaveta K. Titerina, Ana I. Salazar-Puerta, Sayumi Tahara, Nipin Sp, Neil N. Thakkar, Orlando Cómbita-Heredia, Kavya Dathathreya, Alessandro La Ferlita, Yanping Xu, Zhentao Zhang, Raphael Pollock, Daniel Gallego-Perez, Hua Zhu, Christopher M. Hadad, Joal D. Beane. Molecular docking and biological evaluation of a novel IWS1 inhibitor for the treatment of human retroperitoneal liposarcomaScientific Reports 2025; 15(1) doi: 10.1038/s41598-025-07215-y
288
Emilie Darrigues, Zeid A Nima Al Sudani, Fumiya Watanabe, Alexandru S Biris. Plasmonic gap-enhanced Raman tag nanorods for imaging 3D pancreatic spheroids using surface-enhanced Raman spectroscopy and darkfield microscopyNanotechnology 2021; 32(9) doi: 10.1088/1361-6528/abc643
289
Yuanhao Xie, Chenqi Tang, Zizhan Huang, Sicheng Zhou, Yuwei Yang, Zi Yin, Boon Chin Heng, Weishan Chen, Xiao Chen, Weiliang Shen. Extracellular Matrix Remodeling in Stem Cell Culture: A Potential Target for Regulating Stem Cell FunctionTissue Engineering Part B: Reviews 2022; 28(3) doi: 10.1089/ten.teb.2021.0066
290
Prakash Gangadaran, Ramya Lakshmi Rajendran, Ji Min Oh, Jaeyoung Son, Chae Moon Hong, Byeong-Cheol Ahn. Bioinspired artificial nanovesicles engineered from 3D spheroid-cultured UC-MSCs enhance angiogenic activity in vitro: functional proof-of-concept for ischemic applicationsFrontiers in Cell and Developmental Biology 2026; 14 doi: 10.3389/fcell.2026.1695559
291
Miriam Pérez-Cova, Carmen Bedia, Antonio Checa, Isabel Meister, Romà Tauler, Craig E. Wheelock, Joaquim Jaumot. Metabolomic and sphingolipidomic profiling of human hepatoma cells exposed to widely used pharmaceuticalsJournal of Pharmaceutical and Biomedical Analysis 2024; 249 doi: 10.1016/j.jpba.2024.116378
292
Meina Li, Alastair G. Stewart. Comprehensive Pharmacology2022;  doi: 10.1016/B978-0-12-820472-6.00028-1
293
C. T. Mierke. Biomaterial Based Approaches to Study the Tumour Microenvironment2022;  doi: 10.1039/9781839166013-00060
294
Simrit Safarulla, Pritisha S. Khillar, Sudarshan Kini, Amit Kumar Jaiswal. Tissue engineered scaffolds as 3D models for prostate cancer metastasis to boneMaterials Today Communications 2021; 28 doi: 10.1016/j.mtcomm.2021.102641
295
Eric Wang, Melisa J. Andrade, Quinton Smith. Vascularized liver-on-a-chip model to investigate nicotine-induced dysfunctionBiomicrofluidics 2023; 17(6) doi: 10.1063/5.0172677
296
Fakhrossadat Emami, Asmita Banstola, Jee-Heon Jeong, Simmyung Yook. Cetuximab-anchored gold nanorod mediated photothermal ablation of breast cancer cell in spheroid model embedded with tumor associated macrophageJournal of Industrial and Engineering Chemistry 2022; 106 doi: 10.1016/j.jiec.2021.10.029
297
Daniela Rodrigues, Luke Coyle, Barbara Füzi, Sofia Ferreira, Heeseung Jo, Bram Herpers, Seung-Wook Chung, Ciarán Fisher, Jos C. S. Kleinjans, Danyel Jennen, Theo M. de Kok. Unravelling Mechanisms of Doxorubicin-Induced Toxicity in 3D Human Intestinal OrganoidsInternational Journal of Molecular Sciences 2022; 23(3) doi: 10.3390/ijms23031286
298
Vikram Surendran, Simrit Safarulla, Christian Griffith, Reem Ali, Ankit Madan, William Polacheck, Arvind Chandrasekaran. Magnetically Integrated Tumor–Vascular Interface System to Mimic Pro-angiogenic Endothelial Dysregulations for On-Chip Drug TestingACS Applied Materials & Interfaces 2024; 16(36) doi: 10.1021/acsami.4c01766
299
Octavio Bignardi da Silva Nunes, Tiago Willian Buranello, Fabiana de Andrade Farias, Jenyffer Rosero, Kaiana Recchia, Fabiana Fernandes Bressan. Can cell-cultured meat from stem cells pave the way for sustainable alternative protein?Current Research in Food Science 2025; 10 doi: 10.1016/j.crfs.2025.100979
300
Pius N. Amartey, Jocelyn S. Kim, Yetunde I. Kayode, Glenn E. Simmons. An Open-Source Automated Pipeline for Quantitative Morphological Analysis of 3D-Bioprinted Cancer Cell SpheroidsMethods and Protocols 2026; 9(1) doi: 10.3390/mps9010021
301
Jingshu Liu, Sihan Liu, Li Zeng, Irene Tsilioni. Amyloid Beta Peptides Lead to Mast Cell Activation in a Novel 3D Hydrogel ModelInternational Journal of Molecular Sciences 2023; 24(15) doi: 10.3390/ijms241512002
302
Patrick Bédard, Sara Gauvin, Karel Ferland, Christophe Caneparo, Ève Pellerin, Stéphane Chabaud, Stéphane Bolduc. Innovative Human Three-Dimensional Tissue-Engineered Models as an Alternative to Animal TestingBioengineering 2020; 7(3) doi: 10.3390/bioengineering7030115
303
Quratulain Babar, Ayesha Saeed, Tanveer A. Tabish, Mohsin Sarwar, Nanasaheb D. Thorat. Targeting the tumor microenvironment: Potential strategy for cancer therapeuticsBiochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2023; 1869(6) doi: 10.1016/j.bbadis.2023.166746
304
Grace A. R. Rohaley, Elda Hegmann. The importance of structure property relationship for the designing of biomaterials using liquid crystal elastomersMaterials Advances 2022; 3(14) doi: 10.1039/D2MA00401A
305
Adelaida Hernaiz, Paula Cobeta, Belén Marín, Francisco José Vázquez, Juan José Badiola, Pilar Zaragoza, Rosa Bolea, Inmaculada Martín-Burriel. Susceptibility of Ovine Bone Marrow-Derived Mesenchymal Stem Cell Spheroids to Scrapie Prion InfectionAnimals 2023; 13(6) doi: 10.3390/ani13061043
306
Wahyunia L Septiana, Raudina Azzahra, Afifah Azizah Ahmad, Dharma Nurvianto, M. Faishal Budi Utomo, Helsy Junaidi, Sastia Winda Astuti. Comparison of 2D and 3D culture methods on morphology, viability, surface markers, and pluripotency gene of umbilical cord mesenchymal stem cellsJournal of Cellular Biotechnology 2025; 11(2) doi: 10.1177/23523689251359483
307
Inês M. Gonçalves, Violeta Carvalho, Raquel O. Rodrigues, Diana Pinho, Senhorinha F. C. F. Teixeira, Ana Moita, Takeshi Hori, Hirokazu Kaji, Rui Lima, Graça Minas. Organ-on-a-Chip Platforms for Drug Screening and Delivery in Tumor Cells: A Systematic ReviewCancers 2022; 14(4) doi: 10.3390/cancers14040935
308
Karen Beatriz Méndez Rodríguez, Jorge Armando Jiménez Avalos, Juan Carlos Fernández Macias, Ana Karen González Palomo. Microplastics: challenges of assessment in biological samples and their implication for in vitro and in vivo effectsEnvironmental Science and Pollution Research 2023; 30(57) doi: 10.1007/s11356-023-30853-6
309
Kuk Hui Son, Dong-Ha Kim, Seunghye Park, Hyun Jae Kim, Mira Park, Seung-Jin Kim, Sang Jin Lee, Keunsun Ahn, Jin Woo Lee. Spherical Shell Bioprinting to Produce Uniform Spheroids with Controlled SizesJournal of Functional Biomaterials 2024; 15(11) doi: 10.3390/jfb15110350
310
Gloria Campioni, Valentina Pasquale, Stefano Busti, Giacomo Ducci, Elena Sacco, Marco Vanoni. An Optimized Workflow for the Analysis of Metabolic Fluxes in Cancer Spheroids Using Seahorse TechnologyCells 2022; 11(5) doi: 10.3390/cells11050866
311
Shahin Gavanji, Hazem Zaki, Priyadarshini Panjwani, Eman M. Othman. Linking Experimental Models to Pathophysiology: Oxidative Stress and DNA Damage in Cardiovascular DiseasesInternational Journal of Molecular Sciences 2026; 27(9) doi: 10.3390/ijms27093931
312
Athanasios Blanas, Anouk Zaal, Irene van der Haar Àvila, Maxime Kempers, Laura Kruijssen, Mike de Kok, Marko A. Popovic, Joost C. van der Horst, Sandra J. van Vliet. FUT9-Driven Programming of Colon Cancer Cells towards a Stem Cell-Like StateCancers 2020; 12(9) doi: 10.3390/cancers12092580
313
Stefania Vernazza, Sara Tirendi, Mario Passalacqua, Francesco Piacente, Sonia Scarfì, Francesco Oddone, Anna Maria Bassi. An Innovative In Vitro Open-Angle Glaucoma Model (IVOM) Shows Changes Induced by Increased Ocular Pressure and Oxidative StressInternational Journal of Molecular Sciences 2021; 22(22) doi: 10.3390/ijms222212129
314
Diana M. Abraham, Calvin Herman, Lukasz Witek, Bruce N. Cronstein, Roberto L. Flores, Paulo G. Coelho. Self‐assembling human skeletal organoids for disease modeling and drug testingJournal of Biomedical Materials Research Part B: Applied Biomaterials 2022; 110(4) doi: 10.1002/jbm.b.34968
315
Shu-Wei Huang, Ming-Tsung Sun, Wen-Sen Lee, Ying-shih Su, Yi-Tzu Lee, Ming-Hsien Chiang, Yung-Chih Wang, Ya-Sung Yang, Shian-Chiuan Tzeng, Tien-Yuan Wu, Jui-Sheng Sun, Feng-Huei Lin. Cancer as an infectious disease: A different treatment alternative using a combination of tigecycline and pyrvinium pamoate – An example of breast cancerJournal of Microbiology, Immunology and Infection 2022; 55(1) doi: 10.1016/j.jmii.2020.12.008
316
Felipe Allan da Silva da Costa, Murilo Racy Soares, Maria José Malagutti-Ferreira, Gustavo Ratti da Silva, Francislaine Aparecida dos Reis Lívero, João Tadeu Ribeiro-Paes. Three-Dimensional Cell Cultures as a Research Platform in Lung Diseases and COVID-19Tissue Engineering and Regenerative Medicine 2021; 18(5) doi: 10.1007/s13770-021-00348-x
317
Julia Moldaschl, Farhad Chariyev-Prinz, Stefan Toegel, Maike Keck, Ursula Hiden, Dominik Egger, Cornelia Kasper. Spheroid trilineage differentiation model of primary mesenchymal stem/stromal cells under hypoxia and serum-free culture conditionsFrontiers in Bioengineering and Biotechnology 2024; 12 doi: 10.3389/fbioe.2024.1444363
318
Liyuan Liu, Haixia Liu, Xiaowen Huang, Xiaoli Liu, Chengyun Zheng. A High-Throughput and Uniform Amplification Method for Cell SpheroidsMicromachines 2022; 13(10) doi: 10.3390/mi13101645
319
Won-Woo Cho, Wonbin Park, Dong-Woo Cho, Hee-Gyeong Yi. Principles of Human Organs-on-Chips2023;  doi: 10.1016/B978-0-12-823536-2.00003-1
320
Masoumeh Majidi Zolbin, Fereshteh Aliakbari, Shayesteh Mehdinejadiani, Seyedeh Sima Dayabari, Layla Shojaie, Khawaja Husnain Haider, Joshua Johnson. Stem cells: From Potential to Promise2021;  doi: 10.1007/978-981-16-0301-3_4
321
Jooyoung Ro, Junyoung Kim, Yoon-Kyoung Cho. Recent advances in spheroid-based microfluidic models to mimic the tumour microenvironmentThe Analyst 2022; 147(10) doi: 10.1039/D2AN00172A
322
Naresh Kumar, Divya Sridharan, Arunkumar Palaniappan, Julie A. Dougherty, Andras Czirok, Dona Greta Isai, Muhamad Mergaye, Mark G. Angelos, Heather M. Powell, Mahmood Khan. Scalable Biomimetic Coaxial Aligned Nanofiber Cardiac Patch: A Potential Model for “Clinical Trials in a Dish”Frontiers in Bioengineering and Biotechnology 2020; 8 doi: 10.3389/fbioe.2020.567842
323
Suraj Kumar Singh, Sabiya Abbas, Ajit Kumar Saxena, Swasti Tiwari, Lokendra Kumar Sharma, Meenakshi Tiwari. Critical Role of Three-Dimensional Tumorsphere Size on Experimental OutcomeBioTechniques 2020; 69(5) doi: 10.2144/btn-2020-0081
324
Hande Özkan, Deniz Gülfem Öztürk, Gozde Korkmaz. Transcriptional Factor Repertoire of Breast Cancer in 3D Cell Culture ModelsCancers 2022; 14(4) doi: 10.3390/cancers14041023
325
Nkune Williams Nkune, Heidi Abrahamse. Nanoparticle-Based Drug Delivery Systems for Photodynamic Therapy of Metastatic Melanoma: A ReviewInternational Journal of Molecular Sciences 2021; 22(22) doi: 10.3390/ijms222212549
326
Md Sharifur Rahman, Guangyan Qi, Quan Li, Xuming Liu, Jianfa Bai, Mingshun Chen, Anthony Atala, Xiuzhi Susan Sun. Three-Dimensional Trilineage Differentiation Conditions for Human Induced Pluripotent Stem CellsBioengineering 2025; 12(5) doi: 10.3390/bioengineering12050503
327
Shuqing Yang, Peixian Chen, Xiaofan Mao, KaiRong Lin, Wei Li, Tiancheng He, Huiqi Huang, AiGuo Wu, Wei Luo, Guolin Ye, Guangyu Yao, Dan Zhou. Differential Response to Cisplatin between Co-cultured Cells and Pure Cultured Cells Based on Single-cell RNA Sequencing of Three-dimensional-cultured Breast Cancer CellsFrontiers in Bioscience-Landmark 2024; 29(12) doi: 10.31083/j.fbl2912406
328
Tze Ker Matthew Leong, Wen Shern Lo, Wei En Zen Lee, Benedict Tan, Xing Zhao Lee, Li Wen Justina Nadia Lee, Jia-Ying Joey Lee, Nivedita Suresh, Lit-Hsin Loo, Evan Szu, Joe Yeong. Leveraging advances in immunopathology and artificial intelligence to analyze in vitro tumor models in composition and spaceAdvanced Drug Delivery Reviews 2021; 177 doi: 10.1016/j.addr.2021.113959
329
Habib Joukhdar, Sunny Shinchen Lee, Thomas R. Cox, Yu Suk Choi, Steven G. Wise, Jennifer L. Young, Giselle C. Yeo, Khoon S. Lim. Engineering Aging: Approaches to Model and Deconstruct Biological ComplexityAdvanced Materials 2026; 38(1) doi: 10.1002/adma.202512523
330
Reza Bayat Mokhtari, Bessi Qorri, Manpreet Sambi, Narges Baluch, Sushil Kumar, Bikul Das, Myron R. Szewczuk, Herman Yeger, Hai-Ling Margaret Cheng. 3D Multicellular Stem-Like Human Breast Tumor Spheroids Enhance Tumorigenicity of Orthotopic Xenografts in Athymic Nude Rat ModelCancers 2021; 13(11) doi: 10.3390/cancers13112784
331
Devashree Jahagirdar, Prachi Bangde, Ratnesh Jain, Prajakta Dandekar. Degenerative disease‐on‐a‐chip: Developing microfluidic models for rapid availability of newer therapiesBiotechnology Journal 2021; 16(10) doi: 10.1002/biot.202100154
332
Xiran Yang, Qiangqiang Tang, Chen Lai, Kai Wu, Xuetao Shi. Applications and Prospects of Microfluidic Chips in Orthopaedic DiseasesFrontiers in Materials 2021; 7 doi: 10.3389/fmats.2020.610558
333
Kalaimani Markandan, Yong Wei Tiong, Revathy Sankaran, Sakthinathan Subramanian, Uma Devi Markandan, Vishal Chaudhary, Arshid Numan, Mohammad Khalid, Rashmi Walvekar. Emergence of infectious diseases and role of advanced nanomaterials in point-of-care diagnostics: a reviewBiotechnology and Genetic Engineering Reviews 2024; 40(4) doi: 10.1080/02648725.2022.2127070