Ultrastructure and molecular biological changes of chronic gastritis, gastric cancer and gastric precancerous lesions: a comparative study

doi:10.3748/wjg.v9.i4.851

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Apr 15, 2003 (publication date) through Feb 24, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Clinical Research

World J Gastroenterol. Apr 15, 2003; 9(4): 851-857
Published online Apr 15, 2003. doi: 10.3748/wjg.v9.i4.851

Table 1 Comparison between classification of IM and grading of ATP in CG and GC gastric mucosa n (%)

Groups	n	IM classification				Grading of ATP
Groups	n	I_a	I_b	II_a	II_b	ATP⁺	ATP⁺⁺	IM⁺⁺ + ATP⁺	IM⁺⁺ + ATP⁺⁺	IM⁺⁺⁺ + ATP⁺	IM⁺⁺⁺ + ATP⁺⁺	IM⁺⁺⁺ + ATP⁺⁺⁺
NC	15	2 (13.3)	1 (6.7)
CSG	68	16 (23.5)	8 (11.8)	6 (8.8)	3 (4.4)	8 (11.8)	1 (1.5)		2 (2.9)
CAG	64	16 (25.0)^b	11 (17.2)^b	13 (20.3)^d	13 (20.3)^d	2 (3.1)^d	6 (9.4)^d	7 (10.9)	5 (7.8)^c	1 (1.5)	1 (1.6)
CA	36		4 (11.1)	9 (25.0)^c	16 (44.4)^d^f	1 (2.8)^d	6 (16.7)^d	3 (8.3)	2 (5.6)^c	4 (11.1)^f	7 (19.4) ^f	1 (2.8)

Either Solitary IM or IM with concomitant ATP in CSG, CAG or CA is included in IM classification statistically, compared with NC group. ^aP < 0.05,

^bP < 0.01; compared with CSG group.

^cP < 0.05,

^dP < 0.01; compared with CAG group. ^eP < 0.05,

^fP < 0.01. In table 2-6, the marks are the same as here.

Table 2 The ultrastructures of epithelial nuclei of gastric mucosa in CG and GC n (%)

Group	n	Appearce		Chromatin		Nucleons
Group	n	Nucleoplasmic ratio > 1	Nucleus lobulated	Margination or homogeneity	Perinuclcar concentrated	Hypertrophy or margination	looping
NC	15			1 (6.7)	1 (6.7)
CSG	68	5 (5.7)	2 (2.9)	7 (10.3)	5 (7.4)	2 (2.9)	2 ( 2.9)
CAG	64	20 (1.3)^d	19 (9.7)^d	33 (51.6)^bd	29 (45.3)^bd	27 (42.2)^d	14 (21.9)
CA	36	36 (00.0)^bf	36 (00.0)^bf	17 (47.2)^d	26 (72.2)^bdf	18 (50.0)^d	17 (47.2)^df
IMII_b	8	8 (100.0)^b	5 (62.5) ^h	5 (62.5)^b	6 (75.0)^b	4 (50.0)	3 (37.5)
ATP⁺⁺	13	8 (61.5)^hⁱ	5 (38.5)^h^j	4 (30.8)^bgj	3 (23.1)^bhj	5 (38.5)	1 (7.7)^h^j
IM⁺⁺ + ATP⁺⁺	9	7 (77.8)^h^hⁱ^k	5 (55.5)^h^k	3 (33.3)^bgj	3 (33.3)^bhj	4 (44.4)	3 (33.3)^l
IM⁺⁺⁺ + ATP⁺⁺	8	8 (100.0)^lⁿ	8 (100.0)^j^k^m	5 (62.5)^bkm	6 (75.0)^blm	5 (62.5) ^l^m	3 (37.5)^l

Compared with CA group, ^gP < 0.05,

^hP < 0.01, Compared with IMII_b group,

ⁱP < 0.05,

^jP < 0.01, Compared with ATP⁺⁺ group,

^kP < 0.05,

^lP < 0.01. Compared with IM⁺⁺ + ATP⁺⁺ group,

^mP < 0.05,

ⁿP < 0.01. In table 3-6, the marks are the same as here.

Table 3 Mitochondria utrastructures of gastric mucosa epithelial cells in CG and GC (x^-± s)

Group	n	Number	Swelling or Ovegrowth (%)	Matrix fading (%)	Vacuolar degeneration (%)	Pyknosis (%)	Crista number	Fragmentation and derangement of cristas (%)
NC	15	86.5 ± 27.3	3.4 ± 1.6	3.0 ± 1.1	2.9 ± 1.9	1.1 ± 0.8	12.8 ± 3.2	2.2 ± 1.1
CSG	68	65.4 ± 21.1^b	7.2 ± 3.8^b	7.8 ± 5.0^b	6.4 ± 4.5^b	1.9 ± 0.9^b	8.2 ± 3.2^b	5.8 ± 3.1^b
CAG	64	52.2 ± 20.8^bd	10.9 ± 4.5^bd	11.7 ± 8.6^bd	11.6 ± 7.7^bd	3.7 ± 1.1^bd	6.9 ± 3.5^bc	8.9 ± 3.7^bd
CA	36	38.8 ± 31.5^bde	12.9 ± 4.2^bde	15.6 ± 5.4^bdf	14.6 ± 5.8^bde	3.9 ± 0.6^bd	8.1 ± 1.9^bde	10.5 ± 2.7^bde
IMII_b	8	36.8 ± 30.8^b	13.8 ± 3.2^b	14.1 ± 4.3^b	12.5 ± 3.9^b	3.3 ± 0.8^bg	9.3 ± 2.1^b	7.6 ± 1.1^bh
ATP⁺⁺	13	49.1 ± 27.9^b	11.3 ± 2.9^b	8.3 ± 3.5^bh	9.3 ± 4.7^b	1.9 ± 0.5^bhj	11.3 ± 1.8^hi	5.2 ± 1.2^bhj
IM⁺⁺ + ATP⁺⁺	9	41.3 ± 30.8^b	12.8 ± 2.1^b	12.1 ± 2.8^bg	11.2 ± 3.7^b	2.3 ± 0.3^bhjk	11.0 ± 1.5^ahi	6.2 ± 1.3^bhi
IM⁺⁺⁺ + ATP⁺⁺	8	35.4 ± 31.5^b	13.3 ± 4.3^b	15.2 ± 5.3^bl	12.8 ± 4.3^b	3.9 ± 0.5^bbln	8.4 ± 2.1^bln	8.6 ± 1.0^bhln

Table 4 Nuclear and mitochondriaL Zn, Cu of gastric mucosa in CG and GC (x^-± s)

Group	n	Nuclear		Mitochondria
Group	n	Zn (AT%)	Cu (AT%)	Zn (AT%)	Cu (AT%)
NC	15	7.6 ± 0.4	58.4 ± 0.3	9.2 ± 0.5	58.3 ± 0.3
CSG	68	8.1 ± 0.5^b	58.9 ± 0.5^b	8.6 ± 0.5^b	57.8 ± 0.3^b
CAG	64	8.6 ± 0.4^bd	59.3 ± 0.5^bd	8.3 ± 0.4^bd	57.5 ± 0.3^bd
CA	36	8.8 ± 0.3^bde	59.5 ± 0.4^bde	8.9 ± 0.4^bde	57.1 ± 0.3^bde
IMII_b	8	8.6 ± 0.3^b	59.5 ± 0.4^b	8.6 ± 0.3^b	56.9 ± 0.3^b
ATP⁺⁺	13	8.3 ± 0.4^bhi	59.1 ± 0.4^bhi	9.1 ± 0.4ⁱ	57.0 ± 0.3^b
IM⁺⁺ + ATP⁺⁺	9	8.4 ± 0.5^bg	59.5 ± 0.4^bk	8.6 ± 0.4^bl	56.9 ± 0.3^b
IM⁺⁺⁺ +ATP⁺⁺	8	8.9 ± 0.5^bl	59.7 ± 0.4^b	8.5 ± 0.3^bgl	56.8 ± 0.2^bh

Table 5 Gastric mucosa Zn, Cu, DNA, cAMP and SOD in CG and GC (x^-± s)

Group	n	Zn (WT%)	Cu (WT%)	DNA (IOD)	cAMP (pmol/g)	SOD (u/g)
NC	15	4.1 ± 1.0	5.2 ± 0.8	12.6 ± 2.7	15.9 ± 1.5	170.5 ± 6.1
CSG	68	2.8 ± 1.9^b	4.0 ± 1.5^a	15.2 ± 3.1^b	14.6 ± 1.8^b	163.3 ± 5.6^b
CAG	64	2.0 ± 1.8^bc	3.4 ± 1.5^bd	16.5 ± 3.1^bc	13.4 ± 1.8^bc	161.2 ± 4.3^bc
CA	36	1.5 ± 1.2^bde	2.8 ± 0.9^bde	30.7 ± 8.2^bdf	10.2 ± 3.9^bdf	152.2 ± 3.8^bdf
IMII_b	8	1.7 ± 0.9^b	3.5 ± 0.9^b	27.3 ± 10.3^b	11.9 ± 1.9^b	150.0 ± 2.8^b
TP⁺⁺	13	2.7 ± 1.3^bhi	4.4 ± 0.9^ahi	23.5 ± 8.9^bg	12.4 ± 1.8^bg	161.5 ± 3.8^aj
IM⁺⁺ + ATP⁺⁺	9	2.3 ± 1.5^b	4.1 ± 0.9^bh	25.1 ± 7.2^b	12.0 ± 2.3^b	152.2 ± 2.5^bl
IM⁺⁺⁺ + ATP⁺⁺	8	1.5 ± 0.8^bkm	2.9 ± 0.8^bhin	28.5 ± 9.1^b	10.4 ± 0.8^bil	147.4 ± 2.6^bhln

Table 6 LPO and ³H-TdRLCT of CG and GC (x^-± s)

Group	n	LPO (umol/L)	³H-TdRLCT (Bq/L)
NC	15	2.6 ± 0.6	1079.7 ± 227.4
CSG	68	4.2 ± 0.7^b	867.3 ± 240.5^b
CAG	64	4.5 ± 0.6^bc	800.9 ± 221.8^bc
CA	36	6.8 ± 1.6^bdf	325.7 ± 186.8^bdf
IMII_b	8	6.1 ± 0.9^b	318.9 ± 145.8^b
ATP⁺⁺	13	5.1 ± 1.2^bhi	642.9 ± 174.3^bhj
IM⁺⁺ + ATP⁺⁺	9	6.5 ± 1.1^b	326.3 ± 160.6^bk
IM⁺⁺⁺ + ATP⁺⁺	8	7.6 ± 0.7^bgjlm	316.1 ± 170.7^bl

Citation: Yin GY, Zhang WN, Shen XJ, Chen Y, He XF. Ultrastructure and molecular biological changes of chronic gastritis, gastric cancer and gastric precancerous lesions: a comparative study. World J Gastroenterol 2003; 9(4): 851-857
URL: https://www.wjgnet.com/1007-9327/full/v9/i4/851.htm
DOI: https://dx.doi.org/10.3748/wjg.v9.i4.851