A mouse model of severe acute pancreatitis induced with caerulein and lipopolysaccharide

Table 1 Comparison of the pancreas lesion between groups (n = 8)

Groups	Interstitial edema	Inflammatory infiltration	Parenchyma necrosis	Parenchyma hemorrhage
NS	0.0	0.0	0.0	0.0
Cn	1.95 ± 0.26b	1.12 ± 0.22bc	0.63 ± 0.09bd	0
LPS	0.25 ± 0.03ad	0.25 ± 0.43bd	0	0
Cn+LPS	2.75 ± 0.43bc	2.88 ± 0.33bc	2.75 ± 0.33bd	1.25 ± 0.26bd

^aP < 0.05,

^bP < 0.01, vs NS group;

^cP < 0.05,

^dP < 0.01, vs Cn group.

Table 2 Comparison of pancreatic wet weight and serum amy-lase between groups (^-x±s)

Groups	Pancreatic weight (mg)	Serum amylase (U/L)
NS	247.70 ± 30.20	1861.35 ± 303.36
Cn	337.20 ± 50.90bc	11042.32 ± 528.03bd
LPS	290.10 ± 39.70a	2385.50 ± 73.60b
Cn+LPS	380.00 ± 32.00bc	10031.70 ± 906.19bd

^aP < 0.05,

^bP < 0.01, vs NS group;

^cP < 0.05,

^dP < 0.01, vs LPS group.

Table 3 Comparison of SOD and MDA concentration between groups (^-x±s) (n = 8)

Groups	SOD concentration (NU/mgprot)	MDA concentration (nmol/mgprot)
NS	151.67 ± 10.74	0.74 ± 0.34
Cn	135.73 ± 10.87a	0.79 ± 0.31
LPS	136.05 ± 17.25a	0.97 ± 0.29
Cn+LPS	85.13 ± 11.19bcd	1.22 ± 0.24bd

^aP < 0.05,

^bP < 0.01, vs NS group;

^cP < 0.01, vs LPS group;

^dP < 0.01, vs Cn group.