Effect of endotoxin on portal hemodynamic in rats

Table 1 Effects of LPS on portal hemodynamics

Dose of LPS (mg·kg-1)	PVF (mL·min-1)	P	PVP (kPa)	P	PVR (kPa·min·L-1)	P
0.00	14.0 ± 0.44		1.04 ± 0.020		51
0.10	18.0 ± 0.44	0.000	1.05 ± 0.022	0.743	42	0.001
0.25	22.2 ± 0.66	0.000	1.25 ± 0.026	0.000	44	0.003
0.50	26.2 ± 0.80	0.000	1.50 ± 0.015	0.000	48	0.086
1.00	34.8 ± 0.80	0.000	1.80 ± 0.023	0.000	45	0.003
2.00	39.6 ± 0.74	0.000	1.95 ± 0.035	0.000	44	0.001
4.00	38.8 ± 0.33	0.000	2.05 ± 0.022	0.000	47	0.008

Compare rats accepting intraperitoneal injection of various doses of LPS with rats not accepting LPS.

Table 2 Effects of LPS on portal hemodynamics of sham-operated and PHT rats

Group	PVF (mL·min-1)	PVP (kPa)	PVR (kPa·min·L-1)
Portal vein ligation	32.8 ± 1.6	2.24 ± 0.073	61
Control	22.6 ± 1.7	1.86 ± 0.044	71
Intrahepatic portal occlusion	28.0 ± 2.1	1.95 ± 0.054	61
Control	22.0 ± 2.1	1.74 ± 0.037	67
Sham-operated	34.8 ± 0.7	1.80 ± 0.046	44
Control	14.0 ± 0.4	1.04 ± 0.039	52

Table 3 Alteration of portal hemodynamics of the noncirrhotic and sham-operated rats after injection of LPS

Group	PVF (mL·min-1)	Increment (%)	PVP (kPa)	Increment (%)	PVR (kPa·min·ml-1)	Increment (%)
PVL	10.2 ± 0.8	45.13	0.38 ± 0.047	20.43	-10	-14.08
IPO	6.4 ± 1.14	27.27	0.21 ± 0.026	12.07	-10	-8.96
Sham-operated	20.8 ± 0.84	148.57	0.76 ± 0.038	73.08	-8	-15.38