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©The Author(s) 2002.
World J Gastroenterol. Feb 15, 2002; 8(1): 49-53
Published online Feb 15, 2002. doi: 10.3748/wjg.v8.i1.49
Published online Feb 15, 2002. doi: 10.3748/wjg.v8.i1.49
Table 1 Comparability of age and gender in cases and controls
Factor | Case | Control | χ2 | P |
Age(year) | ||||
< 50 | 28 | 16 | ||
50- | 38 | 44 | ||
≥ 60 | 61 | 41 | 4.73 | 0.094 |
Gender | ||||
Male | 97 | 78 | ||
Female | 30 | 23 | 0.02 | 0.80 |
Table 2 Distributions of smoking, GSTM1 deletion and CYP1A1 genotypes
Factors | Case | Control | OR | OR95%CI | χ2 | P |
Smoking Yes | 69 | 38 | 1.97 | 1.12-3.48 | 6.28 | 0.012 |
No | 58 | 63 | ||||
GSTM1 | ||||||
Deletion | 74 | 44 | 1.81 | 1.03-3.18 | 4.85 | 0.028 |
Exist | 53 | 57 | ||||
CYP1A1 | ||||||
Ile/Ile | 25 | 31 | 1.00 | 1.00 | ||
Ile/Val | 58 | 48 | 1.50 | 0.74-3.03 | 1.48 | 0.22 |
Val/Val | 44 | 22 | 2.48 | 1.12-5.54 | 5.93 | 0.015 |
Table 3 Interaction of smoking and GSTM1 deletion genotype.
Smoking | GSTM1 deletion | Case | Control | OR | OR95%CI | χ2 | P |
No | No | 25 | 37 | 1.00 | |||
Yes | No | 28 | 20 | 2.07 | 0.90-4.80 | 3.48 | 0.062 |
No | Yes | 33 | 26 | 1.88 | 0.86-4.13 | 2.93 | 0.087 |
Yes | Yes | 41 | 18 | 3.37 | 1.49-7.69 | 10.29 | 0.0013 |
Table 4 Interaction of tobacco smoking and CYP1A1 Val/Val genotype
Smoking | CYP1A1(Val/Val) | Case | Control | OR | OR95%CI | χ2 | P |
No | No | 36 | 47 | 1.00 | |||
Yes | No | 47 | 32 | 1.92 | 0.98-3.76 | 4.18 | 0.04 |
No | Yes | 22 | 16 | 1.80 | 0.77-4.20 | 2.18 | 0.14 |
Yes | Yes | 22 | 6 | 4.79 | 1.62-14.83 | 10.30 | 0.0013 |
Table 5 Interaction of CYP1A1 mutation genotypes(Val/Val, Ile/Val) and GSTM1 deletion genotype
GSTM1 deletion | CYP1A1 mutation | Case | Control | OR | OR95%CI | χ2 | P |
No | No | 10 | 20 | 1.00 | |||
No | Yes | 43 | 37 | 2.32 | 0.89-6.14 | 3.61 | 0.057 |
Yes | No | 15 | 11 | 2.73 | 0.81-9.42 | 3.28 | 0.070 |
Yes | Yes | 59 | 33 | 3.58 | 1.39-9.38 | 8.66 | 0.0033 |
Table 6 Analysis of CYP1A1 genotypes in cases and controls with Stratified GSTM1 deletion
CYP1A1 genotype | GSTM1 deletion | existing GSTM1 | ||
Case | Control | Case | Control | |
Ile/Ile | 15 | 11 | 10 | 20 |
Ile/Val | 35 | 19 | 23 | 29 |
Val/Val | 24 | 14 | 20 | 8 |
χ2 | 0.39 | 9.04 | ||
P | 0.83 | 0.011 |
- Citation: Wang AH, Sun CS, Li LS, Huang JY, Chen QS. Relationship of tobacco smoking, CYP1A1, GSTM1 gene polymorphism and esophageal cancer in Xi’an. World J Gastroenterol 2002; 8(1): 49-53
- URL: https://www.wjgnet.com/1007-9327/full/v8/i1/49.htm
- DOI: https://dx.doi.org/10.3748/wjg.v8.i1.49