Research on optimal immunization strategies for hepatitis B in different endemic areas in China

Table 1 Benefit of HB vaccination of the low-dose strategy for three places with different economic development level and different endemicity

	Place
	Longan	Shanghai	Jinan
HBsAg positive rate before vaccination (%)	18.0	10.2	7.6
No. of neonates in 1987	7666	12000	18519
Direct benefit*	286	345	562
Indirect benefit*	683	1571	1852
Total benefit*	969	1916	2414
Total cost*	18	22	42
Net benefit*	951	1893	2372
BCR	52.7	85.8	57.9
DBCR	15.5	15.4	13.5
BCR excluding cost of liver cancer	23.6	67.9	34.8
DBCR excluding cost of liver cancer	9.2	14.2	10.1
HBsAg-positive rate after vaccination (%)	3.1	2.2	1.5

^*10000 Yuan RMB.

Table 2 Comprehensive weighted score analysis of the immunization strategies in different endemic areas

Endemic-area	Immunization strategy	Standard
		A	B	C	D
Heavy	10 μg × 3	97.3	96.2	96.2	107.9
	10 μg × 4	84.7	88.5	88.5	90.2
	10 μg × 3 + HBIG	83.4	89.9	89.9	86.5
	30 μg + 10 μg × 2*	93.1	95.9	95.9	100.4
	20 μg × 3 + 10 μg*	90.6	94.3	94.3	96.8
	20 μg × 3 + HBIG*	91.4	94.8	94.8	97.9
Medium	10 μg × 3	97.3	96.2	96.2	107.9
	10 μg × 4	84.7	88.5	88.5	90.2
	10 μg × 3 + HBIG	80.5	88.1	88.1	82.4
	30 μg + 10 μg × 2*	92.6	95.6	95.6	99.6
	20 μg × 3 + 10 μg*	90.2	94.1	94.1	96.3
	20 μg × 3 + HBIG*	91.2	94.7	94.7	97.7
Low	10 μg × 3	97.3	96.3	96.3	108.0
	10 μg × 4	84.7	88.5	88.5	90.2
	10 μg × 3 + HBIG	78.1	86.6	86.6	79.0
	30 μg + 10 μg × 2*	90.8	94.5	94.5	97.1
	20 μg × 3 + 10 μg*	88.3	92.9	92.9	93.6
	20 μg × 3 + HBIG*	89.6	93.7	93.7	95.4

^*High dose strategy.