Effect of apolipoprotein E gene Hha I restricting fragment length polymorphism on serum lipids in cholecystolithiasis

Table 1 Apolipoprotein E phenotype distributions and allele frequenc ies in patients with gallstones and controls

Groups	n	Phenotype				Allele
		E2/3(%)	E2/4(%)	E3/3(%)	E3/4(%)	ε2(%)	ε3(%)	ε4(%)
Patients	87	10(11.4)	0	69(79.4)	8(9.2)	5.8	89.6	4.6
Male	39	4(10.2)	0	31(79.4)	4(10.2)	5.1	89.8	5.1
Female	48	6(12.5)	0	38(79.1)	4(8.9)	6.3	89.6	4.2
Controls	50	5(10.0)	2(4.0)	37(74.1)	6(12.0)	7.0	85.0	8.0
Male	27	3(10.0)	1(3.7)	20(74.0)	3(11.0)	7.4	85.2	7.4
Female	23	2(8.6)	1(4.3)	17(74.6)	3(13.0)	6.5	84.8	8.7

Table 2 Comparisons of lipid levels in E_2/2, E_3/3, E_3/4 both gallstone patients and controls

Lipids (mmol/L)	E2/3		E3/3		E3/4
	Patients (n = 10)	Controls (n = 5)	Patients (n = 69)	Controls (n = 37)	Patients (n = 8)	Controls (n = 6)
TG	1.43 ± 0.35a	1.06 ± 0.10	0.97 ± 0.21	0.64 ± 0.44	1.11 ± 0.33	0.92 ± 0.16
TC	2.99 ± 0.65	2.52 ± 0.53	3.14 ± 0.59	3.67 ± 0.76	3.94 ± 0.45	3.62 ± 0.63
LDL-C	1.41 ± 0.56a	2.04 ± 0.16	1.87 ± 0.49	2.43 ± 0.67	1.92 ± 0.64	2.46 ± 0.32
VLDL-C	0.68 ± 0.26a	0.48 ± 0.20	0.46 ± 0.20	0.30 ± 0.11	0.42 ± 0.13	0.44 ± 0.10
HDL-C	0.95 ± 0.23	1.02 ± 0.15	0.89 ± 0.30a	1.28 ± 0.23	0.86 ± 0.21	0.90 ± 0.36
HDL2-C	0.53 ± 0.13	0.62 ± 0.22	0.49 ± 0.18b	0.73 ± 0.13	0.44 ± 0.19	0.55 ± 0.18
HDL3-C	0.42 ± 0.12	0.56 ± 0.28	0.39 ± 0.12b	0.55 ± 0.11	0.40 ± 0.13	0.46 ± 0.12

^aP < 0.05,

^bP < 0.01, vs controls; F test.

Table 3 The comparisons of lipid levels in E_3/3 same gender ei ther gallstone patients or controls

Lipids (mmol/L)	Male		Female
	Patients (n = 31)	Controls (n = 20)	Patients (n = 38)	Controls (n = 17)
TG	0.85 ± 0.50	0.53 ± 0.22	1.10 ± 0.30	0.72 ± 0.57
TC	3.05 ± 0.44	0.41 ± 0.57	3.23 ± 0.85	3.87 ± 0.63
LDL-C	1.86 ± 0.68	2.71 ± 0.49	1.89 ± 0.86	2.20 ± 0.56
VLDL-C	0.40 ± 0.24	0.25 ± 0.10	0.52 ± 0.14	0.35 ± 0.17
HDL-C	0.94 ± 0.33	1.21 ± 0.28	0.82 ± 0.27b	1.33 ± 0.19
HDL2-C	0.52 ± 0.22	0.69 ± 0.16	0.46 ± 0.15b	0.77 ± 0.10
HDL3-C	0.42 ± 0.12	0.52 ± 0.13	0.36 ± 0.12b	0.57 ± 0.10

^bP < 0.01, vs controls, F test.