A new rat model of portal hypertension induced by intraportal injection of microspheres

Table 1 Intraportally injected aliquots of microspheres

Group	Sphere diameter (μm)	No of aliquots	No ofmspheres/aliquot	Total No of spheres
1	15	6	5.6 × 106	3.4 × 107
2	80	5	9.0 × 104	4.5 × 105
3	15,40,80	15 μm× 2	5.6 × 106	1.1 × 107
		40 μm× 2	2.4 × 105	4.8 × 105
		80 μm× 2	9.0 × 104	1.8 × 105
4	80,40,15	80 μm× 2	9.0 × 104	1.8 × 105
		40 μm× 2	2.4 × 105	4.8 × 105
		15 μm× 2	5.6 × 106	1.1 × 107
5	80	2	9.0 × 104	1.8 × 105

Note: Pressures showed no changes after the 4th and 5th injections in Group 2. Therefore the 6th injection was not given.

Table 2 Comparison of changes in portal venous pressure (PVP) and splenic pulp pressure (SPP) in different groups after microsphere injections

Group	PVP(kPa)				SPP(kPa)
	Basal	Post-infusion	Basal-Post	% increase	Basal	Post-infusion	Basal-Post	% increase
1	0.98 ± 0.21	1.98 ± 0.48a	1.00 ± 0.37a	102.2 ± 35.6a	1.17 ± 0.39	2.01 ± 0.51a	0.84 ± 0.44a	90.9 ± 41.8
2	0.89 ± 0.19	3.19 ± 0.29a	2.30 ± 0.36a	272.2 ± 78.0a	1.44 ± 0.43	3.03 ± 0.33a	1.60 ± 0.60a	139.3 ± 51.7
3	1.02 ± 0.11	2.65 ± 0.49	1.64 ± 0.52	162.8 ± 60.1	1.24 ± 0.16	2.49 ± 0.45	1.24 ± 0.48	103.1 ± 48.5
4	0.98 ± 0.13	2.70 ± 0.13	1.72 ± 0.20	178.6 ± 41.0	1.16 ± 0.19	2.63 ± 0.13	1.49 ± 0.23	133.5 ± 39.2
5	1.04 ± 0.12	2.53 ± 0.17	1.45 ± 0.23c	140.3 ± 32.0c	1.44 ± 0.19	2.47 ± 0.19	1.04 ± 0.28c	74.9 ± 26.6a
6(control)	1.04 ± 0.07	1.02 ± 0.05			1.36 ± 0.20	1.37 ± 0.19

^aP < 0.05, vs other groups;

^cP < 0.05, vs groups 3 and 4. Student’s unpaired t test.