Recommendations for chronic atrophic gastritis research: Highlighting sex-related factors, gastric microbiota, and in-depth mechanistic validation

doi:10.3748/wjg.119553

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Oct 7, 2026; 32(37): 119553
Published online Oct 7, 2026. doi: 10.3748/wjg.119553

Table 1 Traditional Chinese medicine research for treating chronic atrophic gastritis

Ref.	Medicine name	Experimental models	Main findings
[11]	Anwei decoction	Wistar rats (MNNG)	Inflammation↓ NLRP3↓
[12]	Weierning	SD rats (sodium salicylate, alcohol, ammonium hydroxide)	Inflammation↓ apoptosis↓
[13]	Weifuchun capsule	SD rats (MNNG, ethanol)	Regulating immune response, inflammation↓
[14]	Granule Dendrobii	Wistar rats (MNNG)	Inflammation↓ PCNA↓ Bcl-2↓
[15]	Astragali Radix	SD rats (ammonia solution, deoxycholic acid, irregular fasting)	Regulating gut microbiota and metabolic

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Table 2 The changes in the gastric microbiota associated with gastric diseases

Ref.	Year	Sample type	Main findings
[44]	2014	Non-atrophic gastritis (NAG), intestinal metaplasia (IM) and intestinal-type gastric cancer (GC) patients	GC patients: Lactobacillus coleohominis, and Lachnospiraceae↑
[45]	2016	Chronic gastritis and GC patients	GC patients: Lactobacillus, Escherichia-Shigella, Nitrospirae, Burkholderia fungorum, and Lachnospiraceae↑
[42]	2018	Chronic gastritis and gastric carcinoma patients	GC patients: Lactobacillus, Citrobacter, and Phyllobacterium↑
[46]	2021	Superficial gastritis (SG), atrophic gastritis (AG), gastric intraepithelial neoplasia, and GC patients	GC patients: Oral bacteria including Parvimonas, Eikenella, and Prevotella-2↑; Environmental bacteria including Kroppenstedtia, Lentibacillus, and Oceanobacillus↑
[47]	2021	Normal people, advanced AG with IM, and early GC	From controls to IM then to cancer: Gemella, and Streptococcus↑
[43]	2024	SG, AG, IM and GC patients; mice	During the progression of GC: Streptococcus anginosus↑. Streptococcus anginosus promoting gastric inflammation, atrophy, and tumorigenesis
[48]	2025	NAG patients and CAG patients	Peptostreptococcus, fusobacterium, prevotella, sphingomonas and bacteroides were the essential features that distinguish AG from NAG and altered various metabolic pathways

CAG: Chronic atrophic gastritis.

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Citation: Xu FY, Wu CH, Chen HT. Recommendations for chronic atrophic gastritis research: Highlighting sex-related factors, gastric microbiota, and in-depth mechanistic validation. World J Gastroenterol 2026; 32(37): 119553
URL: https://www.wjgnet.com/1007-9327/full/v32/i37/119553.htm
DOI: https://dx.doi.org/10.3748/wjg.119553

Xu FY, Wu CH, Chen HT. Recommendations for chronic atrophic gastritis research: Highlighting sex-related factors, gastric microbiota, and in-depth mechanistic validation. World J Gastroenterol 2026; 32(37): 119553 [DOI: 10.3748/wjg.119553]

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