Synergistic antitumor effects of quercetin and triptolide in hepatocellular carcinoma via modulation of PI3K/AKT/mTOR and Nrf2 signaling pathways

doi:10.3748/wjg.118638

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 32, Issue 33

This Article

(2)

(0)

(8)

Peer-Review Report of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Opinion Review

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Sep 7, 2026; 32(33): 118638
Published online Sep 7, 2026. doi: 10.3748/wjg.118638

Table 1 Phytochemicals and traditional Chinese medicine-derived compounds used in the treatment of hepatocellular carcinoma

Natural compound	Classification	Anticancer efficacy in liver treatment	Ref.
Ashwagandha	Plant-derived product	In combination with cisplatin or intermittent fasting; protective against breast cancer and liver damage	[15]
Becium grandiflorum	Diterpene isolates	In combination with doxorubicin	[16]
Berberine	Plant-derived product	In combination with resveratrol	[17,18]
Naringenin (Ceiba pentandra)	Flavonoid	In combination with doxorubicin	[19,20]
Corydalis Saxicola	Alkaloids	ND	[21]
Curcumin	Diarylheptanoid	Modulates non-coding RNA; in combination with cisplatin	[7,9,18,20,22]
d-Glucaro-1,4-lactone	Secondary metabolite	Antibacterial activity; in combination with lenvatinib	[23]
Lime peel extract	NA	Limonin, hesperidin	[24]
Extracts of Viola canescens	NA	Hepatoprotective effect	[25]
Genistein (Soy)	Phytoestrogen	Chemomodulatory effect	[18,22]
Honokiol (Magnolia)	Lignan	Anticancer activity	[26]
Licochalcone A	Chalcone (secondary metabolite)	In combination with magnesium isoglycyrrhizinate	[27,28]
Luteolin	Flavonoid	Anticancer activity	[4,29]
Moringin	Stable isothiocyanate	Avenanthramide 2f	[30]
Polyphillin I	Secondary metabolite	In combination with chloroquine	[31]
Pomgranate root extract	NA	Antimetastatic	[32]
Quercetin	Flavonoid	Alleviates TP-induced toxicity; enhances doxorubicin and gemcitabine efficacy	[1,2,4,8,18,20,33]
Resveratrol	Polyphenol; phytoestrogen	Antimetastatic effects	[7,17,18,22]
Silymarin	Flavanonol	In combination with doxorubicin	[34]
L-THP	Alkaloid	In combination with DPI	[35]
Thymoquinone	Secondary metabolite	In combination with cisplatin	[18,36]
Xanthohumol	Flavonoid	In combination with resveratrol or phenethyl isothiocyanate	[37]

L-THP: Levo-tetrahydropalmatine; NA: Not applicable; ND: Not done; TP: Triptolide; DPI: Diphenyleneiodonium.

Full Size Table

Citation: Maier I. Synergistic antitumor effects of quercetin and triptolide in hepatocellular carcinoma via modulation of PI3K/AKT/mTOR and Nrf2 signaling pathways. World J Gastroenterol 2026; 32(33): 118638
URL: https://www.wjgnet.com/1007-9327/full/v32/i33/118638.htm
DOI: https://dx.doi.org/10.3748/wjg.118638

Maier I. Synergistic antitumor effects of quercetin and triptolide in hepatocellular carcinoma via modulation of PI3K/AKT/mTOR and Nrf2 signaling pathways. World J Gastroenterol 2026; 32(33): 118638 [DOI: 10.3748/wjg.118638]

All content on this site: Copyright © 1993-2026 Baishideng Publishing Group Inc, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.