Chicken skin mucosa is independently associated with advanced colorectal adenoma with transmembrane member 16A potentially involved in this association

doi:10.3748/wjg.118486

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Sep 7, 2026; 32(33): 118486
Published online Sep 7, 2026. doi: 10.3748/wjg.118486

Table 1 Comparisons of patients with and without chicken skin mucosa, n (%)

Characteristic	CSM group (n = 138)	Non-CSM group (n = 2099)	OR (95%CI)	P value
Age (year), mean ± SD	59.27 ± 10.89	56.90 ± 11.64	2.37 (0.373-4.367)	0.02
Sex			1.031 (0.729-1.459)	0.863
Male	77 (55.8)	1187 (56.6)
Female	61 (44.2)	912 (43.4)
No. of adenomas	-	-	3.624 (2.345-5.600)	< 0.001
Single	24 (17.4)	959 (45.7)
Multiple (n ≥ 2)	114 (82.6)	1140 (54.3)

CSM: Chicken skin mucosa; OR: Odds ratio; CI: Confidence interval.

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Table 2 Characteristics of colorectal adenomas with or without chicken skin mucosa, n (%)

Characteristic	Adenoma with CSM (n = 130)	Adenoma without CSM (n = 2107)	OR (95%CI)	P value
Size (cm)	1.0 (1.0, 1.5)	0.5 (0.5, 0.6)	-6.968 (-8.187 to -5.749)	< 0.001
Morphology			11.715 (2.884-47.585)	< 0.001
Flat (IIa, Is, LST)	2 (1.5)	326 (15.5)
Protruding (Ip, Isp)	128 (98.5)	1781 (84.5)
Location			7.958 (4.854-13.004)	< 0.001
Proximal colon	19 (14.6)	1215 (57.7)
Distal colon	111 (85.4)	892 (42.3)
Histology				< 0.001
Tubular adenoma	61 (46.9)	2065 (98.0)	-
Villous or tubulovillous adenoma	39 (30.0)	24 (1.1)
High-grade neoplasia	30 (23.1)	18 (0.9)
Adenoma type			71.757 (43.325-118.846)	< 0.001
Non-advanced adenoma	20 (15.7)	1957 (92.9)
Advanced adenoma	110 (84.3)	150 (7.1)

CI: Confidence interval; CSM: Chicken skin mucosa; OR: Odds ratio; LST: Laterally spreading tumor.

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Table 3 Multivariable logistic regression analysis

Characteristic	Multivariable logistic regression analysis
Characteristic	OR (95%CI)	P value
Age, year	0.978 (0.950-1.007)	0.136
Sex	0.630 (0.334-1.190)	0.154
Single vs multiple adenomas	1.702 (0.806-3.591)	0.163
Size, cm	1.086 (1.020-1.157)	0.010
Proximal vs distal colon	52.214 (14.781-184.450)	< 0.001
Flat vs protruding	2.555 (0.508-12.837)	0.255
Histology	33.934 (17.441-66.023)	< 0.001
Non-advanced vs advanced adenoma	81.670 (29.902-223.062)	< 0.001

CI: Confidence interval; OR: Odds ratio.

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Table 4 Immunohistochemistry score for transmembrane member 16A among different groups, mean ± SD

Group	Scores of IHC	OR (95%CI)	P value
CSM status
Adenoma with CSM (n = 37)	5.54 ± 3.25	1.33 (0.103-2.557)	0.034
Adenoma without CSM (n = 38)	4.21 ± 1.85	-	-
Adenoma type
Advanced adenoma (n = 39)	6.10 ± 2.77	2.57 (1.488-3.652)	< 0.001
Non-advanced adenoma (n = 36)	3.53 ± 1.87	-	-

CI: Confidence interval; IHC: Immunohistochemistry; OR: Odds ratio.

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Citation: Wang RJ, Hu Y, Guo SB. Chicken skin mucosa is independently associated with advanced colorectal adenoma with transmembrane member 16A potentially involved in this association. World J Gastroenterol 2026; 32(33): 118486
URL: https://www.wjgnet.com/1007-9327/full/v32/i33/118486.htm
DOI: https://dx.doi.org/10.3748/wjg.118486

Wang RJ, Hu Y, Guo SB. Chicken skin mucosa is independently associated with advanced colorectal adenoma with transmembrane member 16A potentially involved in this association. World J Gastroenterol 2026; 32(33): 118486 [DOI: 10.3748/wjg.118486]

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