Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Gastroenterol. Sep 7, 2026; 32(33): 118486
Published online Sep 7, 2026. doi: 10.3748/wjg.118486
Published online Sep 7, 2026. doi: 10.3748/wjg.118486
Chicken skin mucosa is independently associated with advanced colorectal adenoma with transmembrane member 16A potentially involved in this association
Rui-Jie Wang, Yang Hu, Shi-Bin Guo, Department of Gastroenterology, The First Affiliated Hospital of Dalian Medical University, Dalian 116001, Liaoning Province, China
Rui-Jie Wang, Department of Gastroenterology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou 121000, Liaoning Province, China
Co-first authors: Rui-Jie Wang and Yang Hu.
Author contributions: Wang RJ and Hu Y collected and analyzed the data, they contributed equally to this article, they are the co-first authors of this manuscript; Wang RJ, Hu Y, and Guo SB wrote this manuscript; Guo SB designed this study and edited the manuscript; and all authors have read and approved the manuscript.
Institutional review board statement: This study was approved by the Medical Ethics Committee of the First Affiliated Hospital of Dalian Medical University, approval No. PJ-KS-KY-2022-327.
Informed consent statement: Written informed consent was obtained from patients or their relatives.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: The datasets used and/or analyzed during the current study are available from the corresponding author upon reasonable request.
Corresponding author: Shi-Bin Guo, Professor, Department of Gastroenterology, The First Affiliated Hospital of Dalian Medical University, No. 222 Zhongshan Road, Xigang District, Dalian 116001, Liaoning Province, China. guoshibin@firsthosp-dmu.com
Received: January 9, 2026
Revised: April 1, 2026
Accepted: May 6, 2026
Published online: September 7, 2026
Processing time: 212 Days and 15.4 Hours
Revised: April 1, 2026
Accepted: May 6, 2026
Published online: September 7, 2026
Processing time: 212 Days and 15.4 Hours
Core Tip
Core Tip: Chicken skin mucosa (CSM) is an endoscopic, pale-yellow, speckled pattern appearing on colorectal mucosa, typically adjacent to colorectal neoplasm. Our study demonstrated that CSM is independently associated with advanced colorectal adenomas, featuring characteristics such as large size, multiple occurrences, distal location, protruding morphology, and dysplastic histology. Transmembrane member 16A (a calcium-activated chloride channel) expression was significantly higher in advanced than non-advanced adenomas based on immunohistochemistry. The independent link between CSM and advanced colorectal adenoma offers valuable insights for improved clinical decision-making and patient management.