Hua-Zhuo-Jie-Du formula alleviates colitis-associated colorectal cancer via regulating phosphatidylinositol 3-kinase/protein kinase B signaling pathway

doi:10.3748/wjg.119490

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Jul 21, 2026; 32(27): 119490
Published online Jul 21, 2026. doi: 10.3748/wjg.119490

Table 1 Composition of Hua-Zhuo-Jie-Du formula

Chinese name	Latin name	Amount (g)	Place of origin	Lot number
Huang Lian	Coptis chinensis Franch.	0.55	Chongqing, (China)	21100496
Sha Ren	Wurfbainia villosa	0.29	Yunnan Province, (China)	21100297
Bai Jiang Cao	Thlaspi arvense L.	0.75	Hebei Province, (China)	21100396
Qin Pi	Fraxinus chinensis Roxb.	1.09	Sichuan Province, (China)	21100423
Di Yu	Sanguisorba officinalis L.	1.36	Gansu Province, (China)	21100653
Wu Wei Zi	Schisandra chinensis (Turcz.) Baill.	0.6	Jilin Province, (China)	21100823
Feng Wei Cao	Pteris multifida Poir.	1.5	Sichuan Province, (China)	21090074
Yi Yi Ren	Coix lacryma-jobi L.	1.33	Yunnan Province, (China)	21100343
Bai Tou Weng	Pulsatilla chinensis (Bunge) Regel	0.57	Sichuan Province, (China)	21100066
Er Cha	Senegalia catechu	1.2	Yunnan Province, (China)	21100201
Chai Hu	Bupleurum falcatum L.	0.55	Gansu Province, (China)	21100244
Qian Shi	Euryale ferox Salisb.	1	Guangxi Province, (China)	21100533
Dang Gui	Angelica sinensis (Oliv.) Diels	1.6	Gansu Province, (China)	21100398
Bai Zhu	Atractylodes macrocephala Koidz.	1.71	Hebei Province, (China)	21100342
Tu Si Zi	Cuscuta japonica Choisy	0.59	Gansu Province, (China)	21100463
Mu Xiang	Dolomiaea costus (Falc.)	0.86	Yunnan Province, (China)	21100549
Bai Shao	Paeonia lactiflora Pall.	0.95	Anhui Province, (China)	21100361

Full Size Table

Table 2 Fifty-two core targets of Hua-Zhuo-Jie-Du formula for colitis-associated colorectal cancer

No.	Target	Degree	No.	Target	Degree	No.	Target	Degree
1	SRC	68	19	HSP90AA1	36	37	TNF	26
2	AKT1	64	20	ERBB2	36	38	MAPK14	26
3	TP53	64	21	MAPK8	34	39	CCND1	26
4	ESR1	60	22	EP300	34	40	MAPK12	26
5	STAT3	54	23	HIF1A	34	41	PRKCD	26
6	JUN	48	24	CREBBP	32	42	AR	24
7	EGFR	46	25	FOS	32	43	FYN	24
8	MAPK1	46	26	IGF1R	30	44	IKBKB	24
9	PIK3CA	44	27	GRB2	30	45	PLCG1	24
10	MAPK3	42	28	PTK2	30	46	PTPN6	22
11	PIK3R1	42	29	CDC42	30	47	CHUK	22
12	CTNNB1	40	30	STAT1	30	48	VAV1	22
13	AKT2	38	31	BCL2	28	49	MAP3K7	20
14	RELA	38	32	MAPK9	28	50	IL6	20
15	PTPN11	36	33	MDM2	28	51	IKBKG	20
16	NFKB1	36	34	HSP90AB1	28	52	CASP3	20
17	PIK3CD	36	35	RAF1	28
18	PIK3CB	36	36	HDAC1	26

Full Size Table

Citation: Hu SP, Cai YR, Liu Y, Guo YX, Jia XM, Jiang JM, Yang Q. Hua-Zhuo-Jie-Du formula alleviates colitis-associated colorectal cancer via regulating phosphatidylinositol 3-kinase/protein kinase B signaling pathway. World J Gastroenterol 2026; 32(27): 119490
URL: https://www.wjgnet.com/1007-9327/full/v32/i27/119490.htm
DOI: https://dx.doi.org/10.3748/wjg.119490

Hu SP, Cai YR, Liu Y, Guo YX, Jia XM, Jiang JM, Yang Q. Hua-Zhuo-Jie-Du formula alleviates colitis-associated colorectal cancer via regulating phosphatidylinositol 3-kinase/protein kinase B signaling pathway. World J Gastroenterol 2026; 32(27): 119490 [DOI: 10.3748/wjg.119490]

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