Kinetochore-associated protein 1 as a prognostic biomarker in gastric cancer: Integrative bioinformatics and experimental validation

doi:10.3748/wjg.118071

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World Journal of Gastroenterology

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1007-9327

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Jul 21, 2026; 32(27): 118071
Published online Jul 21, 2026. doi: 10.3748/wjg.118071

Table 1 Univariate and multivariate cox regression analyses of clinical characteristics associated with overall survival

Characteristics	Total (n)	Univariate analysis		Multivariate analysis
Characteristics	Total (n)	Hazard ratio (95%CI)	P value	Hazard ratio (95%CI)	P value
Age	367
≤ 65	163	Reference		Reference
> 65	204	1.620 (1.154-2.276)	0.005	1.803 (1.242-2.618)	0.002
Pathologic T stage	362
T1-T2	96	Reference		Reference
T3-T4	266	1.719 (1.131-2.612)	0.011	1.529 (0.971-2.409)	0.067
Pathologic N stage	352
N0-N1	204	Reference		Reference
N2-N3	148	1.650 (1.182-2.302)	0.003	1.630 (1.150-2.311)	0.006
Pathologic M stage	352
M0	327	Reference		Reference
M1	25	2.254 (1.295-3.924)	0.004	2.110 (1.196-3.721)	0.010
Histologic grade	361
G1	10	Reference
G2	134	1.648 (0.400-6.787)	0.489
G3	217	2.174 (0.535-8.832)	0.278
KNTC1	370
Low	185	Reference		Reference
High	185	0.697 (0.502-0.969)	0.032	0.701 (0.497-0.988)	0.043

KNTC1: Kinetochore-associated protein 1; CI: Confidence interval.

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Citation: Li YF, Weng CY, Wang M. Kinetochore-associated protein 1 as a prognostic biomarker in gastric cancer: Integrative bioinformatics and experimental validation. World J Gastroenterol 2026; 32(27): 118071
URL: https://www.wjgnet.com/1007-9327/full/v32/i27/118071.htm
DOI: https://dx.doi.org/10.3748/wjg.118071

Li YF, Weng CY, Wang M. Kinetochore-associated protein 1 as a prognostic biomarker in gastric cancer: Integrative bioinformatics and experimental validation. World J Gastroenterol 2026; 32(27): 118071 [DOI: 10.3748/wjg.118071]

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