Tropomyosin 3 regulates tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma to promote malignant progression in gastric cancer

doi:10.3748/wjg.v32.i22.117290

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Jun 14, 2026; 32(22): 117290
Published online Jun 14, 2026. doi: 10.3748/wjg.v32.i22.117290

Table 1 The association between tropomyosin 3 expression and clinicopathological, n (%)

Characteristics	Expression of TPM3		P value
Characteristics	Low expression of TPM3 (n = 31)	High expression of TPM3 (n = 31)	P value
Age			0.607
≤ 60	14 (22.58)	12 (19.35)
> 60	17 (27.42)	19 (30.65)
Gender			0.799
Male	16 (25.81)	17 (27.42)
Female	15 (24.19)	14 (22.58)
T stage			0.039
Tis-2	17 (27.42)	9 (14.52)
T3-4	14 (22.58)	22 (35.48)
N stage			0.103
N0	13 (20.97)	7 (11.29)
N1-3	18 (29.03)	24 (38.71)
Distant metastasis			0.783
Negative	22 (35.48)	21 (33.87)
Positive	9 (14.52)	10 (16.13)
Tumor node metastasis stage			0.037
I and II	16 (25.81)	8 (12.90)
III and IV	15 (24.19)	23 (37.10)
Tumor differentiation			0.039
Moderate-well	17 (27.42)	9 (14.52)
Poor	14 (22.58)	22 (35.48)

TPM3: Tropomyosin 3.

Full Size Table

Citation: Yue ZQ, Yuan YW, Xu HS, Li XQ, Gan JH, Zou YH, Fan LJ, Xin L. Tropomyosin 3 regulates tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma to promote malignant progression in gastric cancer. World J Gastroenterol 2026; 32(22): 117290
URL: https://www.wjgnet.com/1007-9327/full/v32/i22/117290.htm
DOI: https://dx.doi.org/10.3748/wjg.v32.i22.117290

Yue ZQ, Yuan YW, Xu HS, Li XQ, Gan JH, Zou YH, Fan LJ, Xin L. Tropomyosin 3 regulates tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma to promote malignant progression in gastric cancer. World J Gastroenterol 2026; 32(22): 117290 [DOI: 10.3748/wjg.v32.i22.117290]

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