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World J Gastroenterol. Jun 14, 2026; 32(22): 117290
Published online Jun 14, 2026. doi: 10.3748/wjg.v32.i22.117290
Published online Jun 14, 2026. doi: 10.3748/wjg.v32.i22.117290
Tropomyosin 3 regulates tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma to promote malignant progression in gastric cancer
Zhen-Qi Yue, He-Song Xu, Jin-Heng Gan, Yong-Hui Zou, Luo-Jun Fan, Lin Xin, Department of General Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China
Yi-Wu Yuan, Department of Abdominal Surgery, Jiangxi Cancer Hospital, Nanchang 330006, Jiangxi Province, China
Xue-Qin Li, Department of Nursing, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China
Co-first authors: Zhen-Qi Yue and Yi-Wu Yuan.
Author contributions: Yue ZQ and Yuan YW have played important role in the experimental design as co-first authors; Yuan YW and Xin L designed the research study; Yue ZQ, Xu HS, Li XQ, Gan JH, Zou YH and Fan LJ performed the research; all of the authors read and approved the final version of the manuscript to be published.
Supported by National Natural Science Foundation of China, No. 82573536 and No. 82360591; and Science and Technology Plan of Jiangxi Provincial Health and Wellness Committee, No. 202510043.
Institutional review board statement: The study was reviewed and approved by Institutional Review Board of the Second Affiliated Hospital of Nanchang University (No. 058).
Institutional animal care and use committee statement: All procedures animals were reviewed and approved by the Institutional Animal Care and Use Committee of the Nanchang Royo Biotechnology Co., Ltd. (No. RYE2025021202).
Conflict-of-interest statement: All authors declare no conflict of interest in publishing the manuscript.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: All data generated or analyzed in this study are included in the published article. The dataset used or analyzed in this study can be obtained from the corresponding author upon reasonable request.
Corresponding author: Lin Xin, Academic Fellow, Chief Physician, FRCS (Gen Surg), Professor, Researcher, Department of General Surgery, The Second Affiliated Hospital of Nanchang University, No. 1 Minde Road, Donghu District, Nanchang 330006, Jiangxi Province, China. xindoctor0504@126.com
Received: December 5, 2025
Revised: February 15, 2026
Accepted: March 20, 2026
Published online: June 14, 2026
Processing time: 176 Days and 4.2 Hours
Revised: February 15, 2026
Accepted: March 20, 2026
Published online: June 14, 2026
Processing time: 176 Days and 4.2 Hours
Core Tip
Core Tip: In this study, we investigated the role of tropomyosin 3 (TPM3) in gastric cancer (GC). We found that TPM3 is highly expressed in GC tissues and is associated with poor prognosis. Mechanistically, TPM3 promotes GC cell proliferation, invasion, and metastasis through interaction with tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma and subsequent activation of the mitogen-activated protein kinase signaling pathway. Both in vitro and in vivo experiments demonstrated that the TPM3/tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma axis plays a critical role in GC progression.