Yin Yang 1-associated protein 1: Clinical significance and underlying functional mechanisms in gastric cancer

Table 1 Correlations between Yin Yang 1-associated protein 1 expression with patients’ features

Clinicopathologic features	Cases (n = 118)	YY1AP1 level		P value
		Low (n = 56)	High (n = 62)
Age				0.670
≤ 55 years	44	22	22
> 55 years	74	34	40
Gender				0.443
Female	36	19	17
Male	82	37	45
Localization				0.643
Upper	16	6	10
Middle	55	26	29
Lower	47	24	23
Tumor size				0.017
≤ 5.0 cm	58	34	24
> 5.0 cm	60	22	38
T stage				0.012
T1-T2	49	30	19
T3-T4	69	26	43
Differentiation				0.982
Well	12	6	6
Moderate	57	27	30
Poor	49	23	26
TNM stage				0.018
I-II	56	33	23
III-IV	62	23	39

TNM: Tumor-node-metastasis; YY1AP1: Yin Yang 1-associated protein 1.

Table 2 Kaplan-Meier cancer-specific survival analysis, mean ± SD

Clinicopathologic features	OS months	5-year OS, %	P value
Age, years
≤ 55	63.9 ± 3.4	55.6	0.457
> 55	60.3 ± 2.4	64.6
Gender
Female	58.7 ± 3.5	53.9	0.621
Male	62.7 ± 2.5	64.4
Localization
Upper	48.2 ± 4.0	33.1	0.229
Middle	64.3 ± 2.8	66.8
Lower	60.1 ± 3.0	58.9
Tumor size, cm
≤ 5.0	65.0 ± 2.5	64.1	0.172
> 5.0	57.6 ± 3.0	57.5
T stage
T1-T2	68.0 ± 2.7	74.8	0.018
T3-T4	56.6 ± 2.8	49.0
Differentiation
Well	68.0 ± 5.3	81.8	0.002
Moderate	66.3 ± 2.5	72.1
Poor	51.9 ± 2.8	42.3
TNM stage
I-II	67.6 ± 2.5	65.4	0.013
III-IV	56.0 ± 2.9	57.1
YY1AP1 level
Low	67.4 ± 2.4	72.7	0.014
High	56.0 ± 3.0	48.4

OS: Overall survival; YY1AP1: Yin Yang 1-associated protein 1; TNM: Tumor-node-metastasis.

Table 3 Multivariate analysis

Clinicopathologic features	HR	95%CI	P value
T stage (T3-T4 vs T1-T2)	1.385	0.681-2.818	0.368
Differentiation (poor vs well/moderate)	3.175	1.633-6.175	0.001
TNM stage (III-IV vs I-II)	1.637	0.839-3.194	0.149
YY1AP1 (high vs low)	2.155	1.116-4.159	0.022

HR: Hazard ratio; CI: Confidence interval; YY1AP1: Yin Yang 1-associated protein 1; TNM: Tumor-node-metastasis.