Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Gastroenterol. Jun 7, 2026; 32(21): 116527
Published online Jun 7, 2026. doi: 10.3748/wjg.v32.i21.116527
Published online Jun 7, 2026. doi: 10.3748/wjg.v32.i21.116527
Yin Yang 1-associated protein 1: Clinical significance and underlying functional mechanisms in gastric cancer
Ying-Chao Gu, Xin Li, Yuan-Jun Zhao, Tao Wu, Cheng-Guo Zhou, Wen-Liang Hu, Zhi-Wei Fu, Jian-Hao Huang, Zi-Yang Ren, Department of General Surgery, Dazhou Dachuan District People’s Hospital (Dazhou Third People’s Hospital), Dazhou 635711, Sichuan Province, China
Author contributions: Gu YC initiated research, responsible for the study concepts, design, definition of intellectual content, as well as manuscript preparation and editing; Zhou CG conducted the literature research; Gu YC, Li X, Zhao YJ, and Wu T carried out the clinical studies, while Ren ZY performed the experimental studies; Huang JH was in charge of data acquisition; Fu ZW handled data analysis; Hu WL conducted statistical analysis; all authors read and approved the final manuscript.
AI contribution statement: We can ensure that no artificial intelligence tools are used throughout the entire process of manuscript writing, editing, and figure creation.
Institutional review board statement: This study was approved by the Ethics Committee of Dazhou Dachuan District People’s Hospital (Dazhou Third People’s Hospital).
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: All data generated or analyzed during this study are included in this published article.
Corresponding author: Ying-Chao Gu, Department of General Surgery, Dazhou Dachuan District People’s Hospital (Dazhou Third People’s Hospital), No. 700 Hanxing North Street, Sanliping Street, Dachuan District, Dazhou 635711, Sichuan Province, China.
Received: November 18, 2025
Revised: December 17, 2025
Accepted: February 10, 2026
Published online: June 7, 2026
Processing time: 188 Days and 21.1 Hours
Revised: December 17, 2025
Accepted: February 10, 2026
Published online: June 7, 2026
Processing time: 188 Days and 21.1 Hours
Core Tip
Core Tip: This study identifies Yin Yang 1-associated protein 1 (YY1AP1) as an independent prognostic biomarker in gastric cancer. We demonstrate that high YY1AP1 expression, linked to tumor progression and poor survival, promotes cancer cell proliferation and migration by modulating p21, c-myc, and snail pathways. These findings highlight YY1AP1’s potential as both a therapeutic target and a tool for risk stratification.