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Observational Study
Copyright ©The Author(s) 2026.
World J Gastroenterol. Jan 14, 2026; 32(2): 112395
Published online Jan 14, 2026. doi: 10.3748/wjg.v32.i2.112395
Table 1 Multivariable logistic regression analysis evaluating the association between having gastroesophageal reflux symptoms and sociodemographic, lifestyle, and clinical characteristics, n (%)

Participants with GERS (n = 1572, 48.9%)1
Participants without GERS (n = 1584, 49.3%)1
Participants with GERS vs participants without GERS, OR (95%CI)
Age, years2
    18-34224 (14.8)300 (19.8)Reference category
    35-54461 (30.4)447 (29.5)0.896 (0.425-1.889)
    55-75832 (54.8)768 (50.7)0.534 (0.256-1.114)
Gender2
    Female or non-binary783 (51.6)726 (47.9)Reference category
    Male734 (48.4)789 (52.1)0.720 (0.509-1.019)
Educational level3
    Lower292 (19.3)243 (16.1)Reference category
    Middle535 (35.3)525 (34.7)0.964 (0.607-1.531)
    Higher689 (45.4)746 (49.3)0.888 (0.565-1.396)
Civil status3
    Living without a partner343 (22.6)417 (27.5)Reference category
    Living with a partner1173 (77.4)1097 (72.5)1.292 (0.864-1.933)
Migration background3
    Dutch background1417 (93.5)1439 (95.0)
    Western or non-Western background99 (6.5)75 (5.0)
Waist circumference (cm)4,5
    Normal waist circumference456 (56.4)569 (70.8)Reference category
    Increased waist circumference353 (43.6)235 (29.2)1.513 (1.068-2.141)
    Smoking behavior (pack-years), median (IQR)69.0 (17.00)7.5 (13.50)1.011 (0.998-1.023)
Alcohol consumption (units per week)7
    < 7957 (73.3)980 (75.0)
    ≥ 7349 (26.7)326 (25.0)
Hypertension8
    No1185 (78.7)1273 (84.6)Reference category
    Yes321 (21.3)232 (15.4)1.174 (0.753-1.832)
Diabetes9
    No1405 (93.3)1446 (96.2)Reference category
    Yes101 (6.7)57 (3.8)0.853 (0.431-1.689)
Hypercholesterolemia10
    No1208 (80.3)1309 (87.1)Reference category
    Yes297 (19.7)194 (12.9)1.694 (1.051-2.731)
Family history of esophageal cancer11
    No or unknown940 (82.1)1047 (87.3)Reference category
    Yes205 (17.9)152 (12.7)0.870 (0.552-1.372)
Table 2 Multivariable logistic regression analysis evaluating the association between consulting a primary care provider for gastroesophageal reflux symptoms and sociodemographic, lifestyle, and clinical characteristics, n (%)

Participants with GERS who had ever consulted a PCP (n = 661, 42.0%)1
Participants with GERS who had never consulted a PCP (n = 904, 57.5%)1
Participants with GERS who had ever consulted a PCP vs who had never consulted a PCP, OR (95%CI)
Age, years2
    18-3454 (8.5)170 (19.3)Reference category
    35-54173 (27.2)288 (32.7)1.532 (1.053-2.230)
    55-75410 (64.4)422 (48.0)2.244 (1.578-3.192)
Gender2
    Female or non-binary335 (52.6)448 (50.9)
    Male302 (47.4)432 (49.1)
Educational level3
    Lower154 (24.2)138 (15.7)Reference category
    Middle234 (36.7)301 (34.2)0.715 (0.527-0.971)
    Higher249 (39.1)440 (50.1)0.582 (0.432-0.784)
Civil status3
    Living without a partner139 (21.8)204 (23.2)
    Living with a partner498 (78.2)675 (76.8)
Migration background3
    Dutch background594 (93.2)823 (93.6)
    Western or non-Western background43 (6.8)56 (6.4)
Family history of esophageal cancer4
    No or unknown360 (79.6)580 (83.7)
    Yes92 (20.4)113 (16.3)
Duration of GERS1, years
    < 1142 (21.5)415 (45.9)Reference category
    1-5 169 (25.6)242 (26.8)2.099 (1.578-2.791)
    5-10 103 (15.6)109 (12.1)2.655 (1.890-3.730)
    > 10 247 (37.4)138 (15.3)4.827 (3.602-6.469)
Age at onset GERS1, years
    < 30 243 (36.8)367 (40.6)
    30-50262 (39.6)308 (34.1)
    > 50 156 (23.6)229 (25.3)