Monomorphic epitheliotropic intestinal T-cell lymphoma: Clinical, endoscopic and pathological features

doi:10.3748/wjg.v32.i16.117259

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Apr 28, 2026 (publication date) through Apr 20, 2026

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Apr 28, 2026; 32(16): 117259
Published online Apr 28, 2026. doi: 10.3748/wjg.v32.i16.117259

Table 1 Monomorphic epitheliotropic intestinal T-cell lymphoma clinical characteristics: Peking Union Medical College Hospital and literature cohort, %

Characteristic	PUMCH cohort (n = 26)	Literature cohort (n = 130)	P value
Clinical characteristics
Sex (male:female)	15:11	87:42	0.370
Median age, years (range)	61 (37-82)	61 (35-83)
Weight loss	73 (19/26)	46 (60/130)	0.012^a
Abdominal pain	65 (17/26)	59 (77/130)	0.558
Diarrhea	35 (9/26)	39 (51/130)	0.659
Fever	31 (8/26)	48 (21/44)	0.164
Intestinal obstruction	27 (7/26)	18 (23/130)	0.276
Intestinal perforation	31 (8/26)	35 (45/130)	0.705
Laboratory findings
Anemia	65 (13/20)	60 (31/52)	0.675
Hypoalbuminemia	83 (15/18)	92 (36/39)	0.368
Elevated CRP	90 (9/10)	86 (25/29)	1.000
Elevated LDH	0 (0/16)	31 (11/35)	0.011^a
Elevated β2-MG	100 (8/8)
Sites of involvement
Stomach	0	10 (13/126)	0.126
Small intestine	96 (25/26)	84 (106/126)	0.128
Colon and rectum	15 (4/26)	25 (32/126)	0.323
Imaging features
Bowel wall thickening	83 (15/18)	56 (54/96)	0.037^a
Bowel dilation	39 (7/18)	20 (19/96)	0.076
Lymph node enlargement	61 (11/18)	23 (22/96)	0.001^a
Endoscopic features
Diffuse involvement	60 (6/10)
Mucosal edema	100 (10/10)	27 (17/64)	< 0.001^a
Rough/granular surface	100 (10/10)	19 (12/64)	< 0.001^a
Villous blunting	90 (9/10)	23 (15/64)	< 0.001^a
Lymphangiectasia-like change	80 (8/10)
Mosaic pattern	40 (4/10)
Mucosal hyperemia	60 (6/10)	16 (10/64)	0.005^a
Nodular elevations	40 (4/10)	6 (4/64)	0.010^a
Erosion	20 (2/10)	17 (11/64)	1.000
Ulceration	30 (3/10)	66 (42/64)	0.042^a
Mass-like lesion	0	16 (10/64)	0.339

^aP < 0.05.

PUMCH: Peking Union Medical College Hospital; CRP: C-reactive protein; LDH: Lactate dehydrogenase; β2-MG: Β2-microglobulin.

Full Size Table

Table 2 Clinical characteristics: Prediagnostic surgical vs non-surgical groups, %

Characteristic	Total (n = 156)	Non-surgical group (n = 76)	Surgical group (n = 78)	P value
Male	66 (102/155)	70 (53/76)	62 (48/77)	0.334
Female	34 (53/155)	30 (23/76)	38 (29/77)	0.334
Clinical symptoms
Abdominal pain	60 (94/156)	55 (42/76)	65 (51/78)	0.199
Diarrhea	38 (60/156)	54 (41/76)	24 (19/78)	< 0.001^a
Constipation	3 (5/156)	3 (2/76)	4 (3/78)	0.671
Vomiting	9 (14/156)	7 (5/76)	12 (9/78)	0.284
Abdominal distension	21 (32/156)	22 (17/76)	19 (15/78)	0.631
Hematochezia	7 (11/156)	8 (6/76)	6 (5/78)	0.721
Fever	41 (29/70)	43 (16/37)	41 (13/32)	0.826
Weight loss	51 (79/156)	66 (50/76)	37 (29/78)	< 0.001^a
Intestinal obstruction	19 (30/156)	20 (15/76)	19 (15/78)	0.937
Intestinal perforation	34 (53/156)	14 (11/76)	54 (42/78)	< 0.001^a
Ascites	6 (10/156)	7 (5/76)	6 (5/78)	0.966
Bleeding	3 (4/156)	5 (4/76)	0	0.057
Sites of involvement
Stomach	9 (13/152)	14 (10/74)	3 (2/76)	0.016^a
Small intestine	86 (130/152)	82 (61/74)	88 (67/76)	0.322
Colon and rectum	24 (36/152)	35 (26/74)	13 (10/76)	0.002^a
Laboratory findings
Anemia	61 (44/72)	68 (27/40)	53 (17/32)	0.213
Hypoalbuminemia	89 (51/57)	89 (32/36)	90 (19/21)	1.000
Elevated CRP	87 (34/39)	87 (20/23)	88 (14/16)	1.000
Pathological features
CD2+	74 (20/27)	86 (12/14)	58 (7/12)	0.190
CD3+	99 (136/138)	98 (61/62)	99 (73/74)	1.000
CD4-	81 (88/109)	84 (41/49)	78 (46/59)	0.456
CD5-	86 (83/96)	92 (35/38)	82 (47/57)	0.232
CD7+	100 (58/58)	100 (32/32)	100 (25/25)	1.000
CD8+	90 (121/135)	88 (57/65)	91 (62/68)	0.513
CD56+	95 (129/136)	94 (60/64)	97 (68/70)	0.425
CD20+	13 (12/93)	20 (7/35)	9 (5/56)	0.129
TIA-1+	93 (65/70)	80 (20/25)	100 (43/43)	0.005^a
Granzyme B+	68 (40/59)	50 (11/22)	81 (29/36)	0.015^a

^aP < 0.05.

CRP: C-reactive protein; TIA-1: T-cell intracellular antigen 1.

Full Size Table

Citation: Jiang SJ, Ou CZ, Tang H, Li MH, Jia CW, Zhou WX, He ZYT, Li J, Zhang Y, Li JN. Monomorphic epitheliotropic intestinal T-cell lymphoma: Clinical, endoscopic and pathological features. World J Gastroenterol 2026; 32(16): 117259
URL: https://www.wjgnet.com/1007-9327/full/v32/i16/117259.htm
DOI: https://dx.doi.org/10.3748/wjg.v32.i16.117259