Isolated colonic aspergillosis in an immunocompetent individual diagnosed by metagenomic next-generation sequencing: A case report

Table 1 Laboratory findings on admission

Laboratory testing	Results	Reference values	Units
Inflammatory markers
CRP	< 10.0	0-10	mg/mL
PCT	< 0.05	< 0.5	ng/mL
Complete blood count
WBC	4.76	3.5-9.5	× 109/L
HB	150	130-175	g/L
PLT	206	125-350	× 109/L
NEUT	2.31	1.8-6.3	× 109/L
LYMPH	1.94	1.1-3.2	× 109/L
EO	0.06	0.02-0.52	× 109/L
BASO	0.03	0-0.06	× 109/L
Biochemistry
ALT	10.5	7-50	U/L
AST	12.1↓	13-40	U/L
Albumin	48.1	40-55	g/L
Creatinine	62.4	53-115	μmol/L
Sodium	140	137-147	mmol/L
Potassium	3.47↓	3.5-5.3	mmol/L
Stool examination
Parasite	Negative	Negative	-
WBC	Positive	0-1	-
Fungal culture	Negative	Negative	-
FOBT	Negative	Negative	-
Fungal serology
(1,3)-β-D-glucan	< 37.55	< 70	pg/mL
Galactomannan antigen	0.12	≤ 0.5	S/CO
Tumor markers
CEA	3.37	< 5.0	ng/mL
AFP	1	< 7	ng/mL
Tuberculosis
T-SPOT.TB	Positive	Negative	-
γ-IFN	378.0 ↑	< 14	pg/mL
HIV Ag-Ab	Negative	< 1.00	AU/mL
Auto-antibodies
ANA	Negative	Negative	-
dsDNA	Negative	Negative	-
ANAs	Negative	Negative	-
Voriconazole trough level	2.8	1-5.5	μg/mL

γ-IFN: Interferon-gamma; AFP: Alpha-fetoprotein; ALT: Alanine aminotransferase; ANA: Antinuclear antibody; ANAs: Antinuclear antibody profile; AST: Aspartate aminotransferase; BASO: Basophil count; CEA: Carcinoembryonic antigen; CRP: C-reactive protein; dsDNA: Double-stranded DNA; EO: Eosinophil count; FOBT: Fecal occult blood test; HB: Hemoglobin; HIV Ag-Ab: Human immunodeficiency virus antigen-antibody; LYMPH: Lymphocyte count; NEUT: Neutrophil count; PCT: Procalcitonin; PLT: Platelet count; T-SPOT.TB: T-cell spot test for tuberculosis; WBC: White blood cell.