Icariin inhibits tumor-associated neutrophil recruitment via the CXCL8-CXCR2 axis and restrains pro-metastatic programs in colorectal cancer

doi:10.3748/wjg.v32.i11.113325

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Mar 21, 2026 (publication date) through Apr 4, 2026

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Mar 21, 2026; 32(11): 113325
Published online Mar 21, 2026. doi: 10.3748/wjg.v32.i11.113325

Table 1 Primer sequences

Name	Forward	Reverse
SMAD4	GCTGAGTACCGAGGAGCAGA	GGAGGAGGGAGAGGAGGAAG
CXCL1	TGGCATTCAAGGAGTGTGAC	GGTGGCTTGAGGTGAGTGGT
CXCL8	TCTGCAGCTCTGTGTGAAGG	AGACAGAGCTGCAGAAATCAG
TNF-α	AGCCCATGTTGTAGCAAACC	GGTCTGGGCCATAGAACTGA
IL-1β	GCAACTGTTCCTGAACTCAACT	ATCTTTTGGGGTCCGTCAACT
CXCL10	ATCATCCCTGCGAGCCTATCCT	GACCTTTTTTGGCTAAACGCTTTC
Icam2	GACGGTCTCAACTTTTCCTGCC	CCATTTGGTTGTCCTGCATCGG
Arg1	CATTGGCTTGCGAGACGTAGAC	GCTGAAGGTCTCTTCCATCACC
MMP9	GCTGACTACGATAAGGACGGCA	TAGTGGTGCAGGCAGAGTAGGA
GAPDH	TGCACCACCAACTGCTTAGC	GGCATGGACTGTGGTCATGAG

CXCL: C-X-C motif chemokine ligand; TNF-α: Tumor necrosis factor-α; IL-1β: Interleukin-1β; Icam2: Intercellular adhesion molecule 2; Arg1: Arginase 1; MMP9: Matrix metalloproteinase 9; GAPDH: Glyceraldehyde 3-phosphate dehydrogenase.

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Citation: Zhao YH, Chen J, Gong T, Ge HY, Li M. Icariin inhibits tumor-associated neutrophil recruitment via the CXCL8-CXCR2 axis and restrains pro-metastatic programs in colorectal cancer. World J Gastroenterol 2026; 32(11): 113325
URL: https://www.wjgnet.com/1007-9327/full/v32/i11/113325.htm
DOI: https://dx.doi.org/10.3748/wjg.v32.i11.113325