Potential influence of gut microbiota on the process of hypertriglyceridemia-aggravated acute pancreatitis

Table 1 Changes in gut microbiota[29,30,40,92,101,164-166]

Ref.	Sample (sample size)	Differential taxa feature	Sequencing method
Hu et al[29]	Patients with HTG-AP (n = 30). Patients with non-HTG-AP (n = 20)	Increase: Firmicutes, Enterococcaceae, Clostridiales Incertae Sedis XI, Finegoldia, Enterococcus. Decrease: Alpha diversity, Lachnospiraceae, Bacteroidaceae, Bacteroides	16S rRNA sequencing
Li et al[30]	Patients with HTG-AP (n = 25). Patients with non-HTG-AP (n = 30)	Increase: Escherichia-Shigella, Klebsiella. Decrease: Alpha diversity, Bacteroides, Bacteroides uniformis	16S rRNA sequencing
Yun et al[101]	Patients with HTG (n = 259). Healthy controls (n = 882)	Increase: Prevotella, Fusobacterium, Megamonas, Megasphaera, Acidaminococcus. Decrease: Oscillospira, Anaerostipes	16S rRNA sequencing
Zhu et al[92]	Patients with AP (n = 130). Healthy controls (n = 35)	Increase: Proteobacteria, Escherichia-Shigella, Enterococcus, Enterobacteriaceae. Decrease: Bacteroidetes, Prevotella_9, Faecalibacterium, Blautia, Lachnospiraceae, Bifidobacterium	16S rRNA sequencing
Yazici et al[164]	Patients with AP (n = 54). Healthy controls (n = 46)	Increase: Veillonella, Klebsiella, Enterococcus, Actinomyces, Haemophilus. Decrease: Alpha diversity, Faecalibacterium, Blautia	16S rRNA sequencing
Liu et al[40]	Patients with AP (n = 82). Healthy controls (n = 115)	Increase: Escherichia coli, Parabacteroides, Veillonella, Enterococcus. Decrease: Faecalibacterium prausnitzii, Ruminococcus, Eubacterium, Roseburia and Bifidobacterium	Metagenome shotgun sequencing
Zhu et al[92]	AP mice (n = 10). Control mice (n = 5)	Increase: Escherichia-Shigella, Enterococcus, Enterococcaceae. Decrease: Blautia	16S rRNA sequencing
Chen et al[165]	ANP mice (n = 10). SO mice (n = 10)	Increase: Escherichia-Shigella and Phascolarctobacterium. Decrease: Candidatus_Saccharimonas, Prevotellaceae_UCG-001, Lachnospiraceae_UCG-001, Ruminiclostridium_5, and Ruminococcaceae_UCG-008	16S rRNA sequencing
Xiong et al[166]	AP mice (n = 5). SO mice (n = 5)	Increase: No rank of Muribaculaceae, Lachnospiraceae. Decrease: Bifidobacterium, Akkermansia	16S rRNA sequencing

ANP: Acute necrotizing pancreatitis; AP: Acute pancreatitis; HTG: Hypertriglyceridemia; SO: Sham-operated.