BPG is committed to discovery and dissemination of knowledge
Home / Archive / Volume 31, Issue 40
  • This Article
Academic Content and Language Evaluation of This Article
CrossCheck and Google Search of This Article
Academic Rules and Norms of This Article
Citation of this article
Corresponding Author of This Article
Research Domain of This Article
Article-Type of This Article
Open-Access Policy of This Article
Times Cited Counts in Google of This Article
Number of Hits and Downloads for This Article
  • Total Article Views (266)
All Articles published online
The chart showing PDF series, HTML series, Figures (1-4) series, Tables (1-4) series.
Item 
Count 
PDF7
HTML43
Figures (1-4)5
Tables (1-4)3
 Sum=58
Featured Article
The chart showing Browse series, Download series.
Item 
Count 
Browse41
Download86
 Sum=127
Publishing Process of This Article
The chart showing Browse series, Download series.
Item 
Count 
Browse20
Download48
 Sum=68
Oct 28, 2025 (publication date) through Oct 30, 2025
Times Cited of This Article
  • Times Cited  (0)
Journal Information of This Article
Publication Name
World Journal of Gastroenterology
ISSN
1007-9327
Publisher of This Article
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Prospective Study
Copyright ©The Author(s) 2025.
World J Gastroenterol. Oct 28, 2025; 31(40): 111406
Published online Oct 28, 2025. doi: 10.3748/wjg.v31.i40.111406
Table 1 Demographic, clinical and ultrasound parameters at both time points in patients with (responders) and without (non-responders) varices eradication, mean ± SD
Characteristic
Responders (n = 28)
Non-responders (n = 13)
P value
Age, years62.8 ± 7.864.5 ± 7.10.475
Sex, number, M/F21/710/3> 0.99
T0MELD10.1 ± 212.2 ± 1.80.0025
Child (A/B/C), number21/7/01/12/00.00023
Spleen size, cm15.50 ± 2.7415.79 ± 2.150.77
Ascites, yes/no3/257/60.009
Collateral vessels, yes/no6/224/90.797
SA RI0.71 ± 0.120.69 ± 0.050.73
LRA RI0.73 ± 0.170.69 ± 0.060.292
RRA RI0.71 ± 0.140.68 ± 0.050.325
SMA RI0.84 ± 0.090.84 ± 0.080.918
HA RI0.73 ± 0.110.69 ± 0.070.193
PVV, cm/second23.9 ± 5.7922.5 ± 4.160.379
PVD, cm1.25 ± 0.171.27 ± 0.250.91
DI0.44 ± 0.300.49 ± 0.140.450
LSM, kPa26.32 ± 13.4639.62 ± 15.070.013
SSM, kPa47.92 ± 8.5452.03 ± 10.510.232
LP meanLin, AU409.6 ± 356.5717.1 ± 669.20.140
LP PE, AU993.1 ± 920.11547.9 ± 1430.90.218
LP WiR, AU424.8 ± 879.01099.9 ± 2074.10.278
LP mTT, second276.3 ± 203.2181.8 ± 203.40.179
LP TTP, second14.86 ± 7.7311.59 ± 6.710.181
LP AUC, AU45808.7 ± 48761.345046.8 ± 40751.40.959
PV meanLin, AU284.4 ± 237.7340.0 ± 238.20.493
PV PE, AU623.9 ± 582.9772.7 ± 714.50.519
PV WiR, AU81.3 ± 91.6114.7 ± 145.80.459
PV mTTI, second193.7 ± 214.1254.4 ± 225.20.423
PV TTP, second23.71 ± 10.2019.68 ± 6.960.149
PV AUC, AU30180.9 ± 31763.745136.8 ± 35684.00.210
T1MELD9.68 ± 2.1312.46 ± 1.940.0003
Child (A/B/C), number23/5/02/11/00.00019
Spleen size, cm15.5 ± 2.7715.92 ± 2.250.611
Ascites, yes/no5/236/70.127
Collateral vessels, yes/no6/224/90.797
SA RI0.67 ± 0.070.76 ± 0.150.070
LRA RI0.69 ± 0.100.74 ± 0.130.249
RRA RI0.67 ± 0.060.74 ± 0.130.097
SMA RI0.84 ± 0.110.85 ± 0.050.745
HA RI1.01 ± 1.710.72 ± 0.110.373
PVV, cm/second26.66 ± 6.7823.54 ± 5.190.279
PVD, cm12.38 ± 2.2812.62 ± 1.450.690
DI0.46 ± 0.280.31 ± 0.420.274
LSM, kPa25.44 ± 10.1438.33 ± 12.590.0042
SSM, kPa43.29 ± 11.6552.77 ± 11.360.0213
LP meanLin, AU499.4 ± 444.8521.7 ± 464.90.886
LP PE, AU1200.8 ± 1058.6983.0 ± 807.90.474
LP WiR, AU481.4 ± 955.9973.6 ± 1518.20.298
LP mTTI, second261.6 ± 200.9195.6 ± 198.40.334
LP TTP, second12.07 ± 5.9915.19 ± 8.680.191
LP AUC, AU42757.2 ± 43432.234202.5 ± 30970.20.477
PV meanLin, AU782.6 ± 2327.1254.8 ± 209.60.244
PV PE, AU625.5 ± 619.6589.7 ± 622.70.766
PV WiR, AU75.6 ± 62.389.8 ± 104.20.654
PV mTTI, second133.4 ± 150.5256.3 ± 225.80.092
PV TTP, second22.52 ± 7.9119.38 ± 7.830.245
PV AUC, AU32951.1 ± 33858.334981.5 ± 32055.20.854
M: Male; F: Female; MELD: Model for end-stage liver disease; SA: Splenic artery; RI: Resistivity index; LRA: Left renal artery; RRA: Right renal artery; SMA: Superior mesenteric artery; HA: Hepatic artery; PVV: Portal vein velocity; PVD: Portal vein diameter; DI: Damping index; LSM: Liver stiffness measurement; SSM: Spleen stiffness measurement; LP: Liver parenchyma; AU: Arbitrary units; PE: Peak enhancement; WiR: Wash-in rate; mTT: Mean transit time; TTP: Time to peak; AUC: Area under the curve; PV: Portal vein; meanLin: Mean signal intensity.
Full Size Table
Table 2 Longitudinal changes of ultrasound parameters in patients with (responders) and without (non-responders) varices eradication
Responders (n = 28)
Non-responders (n = 13)
P value
ΔMELD-0.39 ± 1.260.23 ± 0.730.053
Δ spleen size-0.00 ± 0.690.12 ± 0.440.481
ΔSA RI-0.037 ± 0.120.069 ± 0.150.033
ΔLRA RI-0.040 ± 0.130.046 ± 0.120.048
ΔRRA RI-0.043 ± 0.120.054 ± 0.110.017
ΔSMA RI0.005 ± 0.140.012 ± 0.050.829
ΔHA RI0.284 ± 1.710.026 ± 0.120.434
ΔPVV1.76 ± 5.531.05 ± 4.950.687
ΔPVD-0.30 ± 0.730.15 ± 0.550.036
ΔDI0.02 ± 0.15-0.18 ± 0.430.132
ΔLSM-0.87 ± 8.03-1.30 ± 4.810.836
ΔSSM-4.63 ± 6.710.74 ± 6.120.018
LP Δ meanLin89.80 (203.31)-195.41 (236.54)0.000004
LP ΔPE207.71 (492.36)-564.87 (817.97)0.000002
LP ΔWiR 156.60 (115.09)-126.34 (1130.23)0.000354
LP ΔmTT-14.66 (131.99)13.77 (142.85)0.084885
LP Δ TTP 10.55 (4.40)0.48 (2.41)0.093950
LP Δ AUC-3051.50 (37324.96)-10844.24 (12302.78)0.000065
PV Δ meanLin498.29 (2348.79)-85.14 (95.27)0.000007
PV ΔPE28.59 (279.21)183.01 (209.36)0.000147
PV ΔWiR 1-5.70 (68.67)-24.82 (42.41)0.000354
PV ΔmTT-50.22 (134.15)1.88 (48.14)0.034408
PV ΔTTP 1-1.19 (6.78)-0.30 (6.45)0.022410
PE ΔAUC2770.26 (12605.83)-10155.34 (15630.37)0.000052
Δ calculated variations between T1 and T0. MELD: Model for end-stage liver disease; SA: Splenic artery; RI: Resistivity index; LRA: Left renal artery; RRA: Right renal artery; SMA: Superior mesenteric artery; HA: Hepatic artery; PVV: Portal vein velocity; PVD: Portal vein diameter; DI: Damping index; LSM: Liver stiffness measurement; SSM: Spleen stiffness measurement; LP: Liver parenchyma; PE: Peak enhancement; WiR: Wash-in rate; mTT: Mean transit time; TTP: Time to peak; AUC: Area under the curve; PV: Portal vein; meanLin: Mean signal intensity.
Full Size Table
Table 3 Independent predictors of variceal eradication according to multivariate analysis
LASSO coefficient
β coefficient
Odds ratio
T1 Child-Pugh-0.84-0.840.43
PV ΔAUC0.340.321.38
T1 LSM-0.33-0.610.54
LP ΔPE0.280.511.66
T1 SSM-0.16-0.570.57
ΔSA RI-0.14-0.910.40
ΔRRA RI-0.13-0.280.75
T0 Child-Pugh-0.11-0.510.60
PV ΔPEApproximately = 00.151.16
Δ calculated variations between T1 and T0. AUC: Area under the curve; PV: Portal vein; LSM: Liver stiffness measurement; LP: Liver parenchyma; PE: Peak enhancement; SSM: Spleen stiffness measurement; SA: Splenic artery; RI: Resistivity index; RRA: Right renal artery; LASSO: Least absolute shrinkage and selection operator.
Full Size Table
Table 4 Clinical score based on 9-variables model
Predictor
Points
Child-Pugh T1 ≥ B1
LSM T1 ≥ 20 kPa1
SSM T1 ≥ 50 kPa1
ΔSA RI ≤ -0.051
ΔRRA RI ≤ -0.031
LP ΔPE ≥ 10 AU-1
PV ΔAUC ≥ 30 AU-1
PV ΔPE ≥ 5 AU-1
Child-Pugh T0 ≥ B1
Δ calculated variations between T1 and T0. LSM: Liver stiffness measurement; SSM: Spleen stiffness measurement; SA: Splenic artery; RI: Resistivity index; RRA: Right renal artery; LP: Liver parenchyma; PE: Peak enhancement; AUC: Area under the curve; PV: Portal vein; AU: Arbitrary units.
Full Size Table
Write to the Help Desk
© 2004-2025 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

California Corporate Number: 3537345