Associations between complete-blood-count-derived inflammatory markers and gastric ulcer: A cross-sectional study

Table 1 Characteristics of participants by gastric ulcer status, n (%)

Variables	Total (n = 243)	Control (n = 77)	GU (n = 166)	P value
Age, median (Q1, Q3)	60 (49, 70)	49 (41, 59)	65 (53, 72.75)	< 0.001
Gender				< 0.001
Female	89 (37)	44 (57)	45 (27)
Male	154 (63)	33 (43)	121 (73)
Marital status				0.470
No	9 (4)	4 (5)	5 (3)
Yes	234 (96)	73 (95)	161 (97)
Hypertension				< 0.001
No	160 (66)	65 (84)	95 (57)
Yes	83 (34)	12 (16)	71 (43)
Diabetes				< 0.001
No	208 (86)	75 (97)	133 (80)
Yes	35 (14)	2 (3)	33 (20)
Stroke				0.006
No	229 (94)	77 (100)	152 (92)
Yes	14 (6)	0 (0)	14 (8)
SCr, median (Q1, Q3)	76.5 (61.2, 89.87)	68.93 (58.2, 79.3)	79.21 (65.2, 100.39)	< 0.001
BUN, median (Q1, Q3)	5.92 (4.74, 10.50)	5.03 (4.32, 5.67)	7.85 (5.2, 12.87)	< 0.001
eGFR				< 0.001
eGFR < 90	104 (43)	19 (25)	85 (51)
eGFR ≥ 90	139 (57)	58 (75)	81 (49)
NLR, median (Q1, Q3)	2.76 (1.76, 4.9)	1.77 (1.38, 2.44)	3.64 (2.25, 6.09)	< 0.001
MLR, median (Q1, Q3)	0.26 (0.19, 0.39)	0.18 (0.14, 0.24)	0.33 (0.23, 0.44)	< 0.001
PLR, median (Q1, Q3)	139.58 (101.62, 188.03)	129.38 (98.43, 154.55)	151.5 (105.71, 212.56)	0.012
SIRI, median (Q1, Q3)	1.14 (0.65, 2.1)	0.55 (0.39, 0.88)	1.7 (1.01, 2.67)	< 0.001
SII, median (Q1, Q3)	597.49 (362.79, 1029.33)	378.86 (286.71, 536)	710.16 (458.43, 1283.22)	< 0.001
AISI, median (Q1, Q3)	243.99 (118.20, 480.31)	115.65 (86.15, 192.96)	332.51 (198.92, 665.44)	< 0.001
log2 NLR, median (Q1, Q3)	1.47 (0.82, 2.29)	0.82 (0.46, 1.29)	1.86 (1.17, 2.61)	< 0.001
log2 MLR, median (Q1, Q3)	-1.93 (-2.43, -1.35)	-2.49 (-2.82, -2.08)	-1.61 (-2.12, -1.2)	< 0.001
log2 PLR, median (Q1, Q3)	7.12 (6.67, 7.55)	7.02 (6.62, 7.27)	7.24 (6.72, 7.73)	0.012
log2 SIRI, median (Q1, Q3)	0.19 (-0.61, 1.07)	-0.87 (-1.37, -0.18)	0.77 (0.02, 1.41)	< 0.001
log2 SII, median (Q1, Q3)	9.22 (8.5, 10.01)	8.57 (8.16, 9.07)	9.47 (8.84, 10.33)	< 0.001
log2 AISI, median (Q1, Q3)	7.93 (6.89, 8.91)	6.85 (6.43, 7.59)	8.38 (7.64, 9.38)	< 0.001

GU: Gastric ulcer; SCr: Serum creatinine; BUN: Blood urea nitrogen; eGFR: Estimated glomerular filtration rate; NLR: Neutrophil-to-lymphocyte ratio; MLR: Monocyte-to-lymphocyte ratio; PLR: Platelet-to-lymphocyte ratio; SIRI: Systemic inflammatory response index; SII: Systemic immune-inflammation index; AISI: Aggregate index of systemic inflammation.

Table 2 Results of weighted logistic regression analysis examining the association between complete blood count-derived inflammatory markers and gastric ulcer

	Model 1		Model 2		Model 3
	OR (95%CI)	P value	OR (95%CI)	P value	OR (95%CI)	P value
log2 NLR	4.5 (2.87, 7.05)	< 0.001	3.85 (2.35, 6.29)	< 0.001	3.20 (1.85, 5.56)	< 0.001
log2 MLR	5.01 (3.01, 8.34)	< 0.001	3.79 (2.20, 6.52)	< 0.001	4.14 (2.31, 7.44)	< 0.001
log2 PLR	1.14 (0.88, 1.48)	0.333	1.20 (0.87, 1.65)	0.273	1.49 (1.04, 2.12)	0.029
log2 SIRI	4.01 (2.72, 5.89)	< 0.001	3.74 (2.43, 5.76)	< 0.001	3.04 (1.94, 4.77)	< 0.001
log2 SII	1.86 (1.42, 2.43)	< 0.001	1.90 (1.40, 2.58)	< 0.001	1.83 (1.33, 2.50)	< 0.001
log2 AISI	1.96 (1.55, 2.48)	< 0.001	2.05 (1.57, 2.67)	< 0.001	1.94 (1.45, 2.57)	< 0.001

Model 1: Did not adjust for any confounding factors. Model 2: Adjusted for age, gender, and marital status. Model 3: Adjusted for age, gender, marital status, hypertension, diabetes, stroke, serum creatinine, and blood urea nitrogen. CI: Confidence interval; OR: Odds ratio; NLR: Neutrophil-to-lymphocyte ratio; MLR: Monocyte-to-lymphocyte ratio; PLR: Platelet-to-lymphocyte ratio; SIRI: Systemic inflammatory response index; SII: Systemic immune-inflammation index; AISI: Aggregate index of systemic inflammation.