Ambroxol mitigates cyclophosphamide-induced liver injury by suppressing TLR-4/NF-κB signaling and oxidative stress and upregulating cytoglobin, TXNRD1 and HMGB1

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 31, Issue 35

This Article

Academic Content and Language Evaluation of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

All Articles published online

Item

Count

PDF

HTML

Figures (1-8)

Tables (1-1)

Sum=22

Sep 21, 2025 (publication date) through Sep 18, 2025

Times Cited of This Article

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Basic Study

World J Gastroenterol. Sep 21, 2025; 31(35): 108139
Published online Sep 21, 2025. doi: 10.3748/wjg.v31.i35.108139

Table 1 Binding affinities and interaction of ambroxol with different protein targets

	Lowest binding energy (kcal/mol)	Polar bonds	Hydrophobic interactions
Cytoglobin	-5.1		Val47, Val51, Arg48, Pro69
TXNRD1	-6.6	Glu477, Thr480	Val474, Cys475, Ile347, Pro344, Thr481, Val478, Phe406
HMGB1	-4.9	Ser12, Ala13, Asn46	Lys39, Gly42, Ala38, Phe14

TXNRD1: Thioredoxin reductase 1; HMGB1: High-mobility group box 1.

Citation: Alruhaimi RS, Hassanein EHM, Alnasser SM, Ahmeda AF, Althagafy HS, Abd El-Ghafar OAM, Mahmoud AM. Ambroxol mitigates cyclophosphamide-induced liver injury by suppressing TLR-4/NF-κB signaling and oxidative stress and upregulating cytoglobin, TXNRD1 and HMGB1. World J Gastroenterol 2025; 31(35): 108139
URL: https://www.wjgnet.com/1007-9327/full/v31/i35/108139.htm
DOI: https://dx.doi.org/10.3748/wjg.v31.i35.108139