Efficacy and safety of different doses of dexmedetomidine on gastrointestinal function recovery after laparoscopic colorectal surgery

doi:10.3748/wjg.v31.i31.110582

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 31, Issue 31

This Article

Academic Content and Language Evaluation of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (577)

All Articles published online

The chart showing PDF series, HTML series, Figures (1-1) series, Tables (1-6) series.

Item

Count

PDF

HTML

226

Figures (1-1)

Tables (1-6)

Sum=312

Featured Article

The chart showing Browse series, Download series.

Item

Count

Browse

Download

191

Sum=234

Publishing Process of This Article

Item

Count

Browse

Download

Sum=12

Aug 21, 2025 (publication date) through Aug 21, 2025

Times Cited of This Article

Times Cited (0)

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Cohort Study

World J Gastroenterol. Aug 21, 2025; 31(31): 110582
Published online Aug 21, 2025. doi: 10.3748/wjg.v31.i31.110582

Table 1 Comparison of baseline characteristics among the three groups, mean ± SD/n (%)

Item	Control (n = 281)	Low-dose (n = 313)	High-dose (n = 285)
Age (year)	66.94 ± 8.68	65.91 ± 8.76	66.32 ± 9.14
Gender
Male	159 (56.58)	175 (55.91)	170 (59.65)
Female	122 (43.41)	138 (44.08)	115 (40.35)
BMI (kg/m²)	23.65 ± 3.03	23.78 ± 3.73	24.82 ± 3.44
ASA grading
I	8 (2.84)	14 (4.47)	11 (3.86)
II	228 (81.14)	265 (84.66)	243 (85.26)
III	45 (16.01)	34 (10.86)	31 (10.88)
Hypertension	41 (14.59)	32 (10.22)	35 (12.28)
Diabetes	14 (4.98)	10 (3.19)	17 (5.96)
Coronary heart disease	23 (8.19)	26 (8.31)	20 (7.02)

BMI: Body mass index; ASA: American Society of Anesthesiologists.

Table 2 Comparison of indicators related to surgical and anesthesia among the three groups, mean ± SD/n (%)

Item	Control (n = 281)	Low-dose (n = 313)	High-dose (n = 285)
Site of surgery
Proctectomy	88 (31.32)	96 (30.67)	102 (35.79)
Colectomy	193 (68.68)	217 (69.33)	183 (64.21)
Right hemicolectomy	122 (43.41)	141 (45.05)	113 (39.65)
Left hemicolectomy	61 (21.71)	63 (20.13)	59 (20.70)
Total colectomy	10 (3.56)	13 (4.15)	11 (3.86)
Operation time (minute)	207.97 ± 22.35	210.42 ± 23.03	208.97 ± 22.79
Anesthesia time (minute)	283.80 ± 23.17	285.25 ± 24.06	286.60 ± 25.06
Extubate time (minute)	21.54 ± 4.95	22.29 ± 6.47	23.20 ± 6.65^a^,¹
Dose of dexmedetomidine (μg)	0	69.97 ± 11.71	159.51 ± 27.71^a^,²
Propofol (mg)	1080.72 ± 197.13	1002.78 ± 184.6^a^,¹	1005.08 ± 183.30^a^,¹
Sufentanil (μg)	27.52 ± 5.41	26.74 ± 5.53	26.18 ± 5.12^a^,¹
Remifentanil (mg)	3.28 ± 0.63	2.67 ± 0.51^a^,¹	2.59 ± 0.50^a^,¹
Cisatracurium (mg)	23.10 ± 2.52	22.89 ± 2.62	23.24 ± 2.73

^aP < 0.05.

¹P compared with the control group.

²P compared with low-dose group.

Table 3 Comparison of postoperative gastrointestinal function among the three groups, mean ± SD/n (%)

	Control (n = 281)	Low-dose (n = 313)	High-dose (n = 285)	Low-dose vs control MD (95%CI)	High-dose vs control MD (95%CI)
Time to first flatus (hour)	76.21 ± 5.32	65.56 ± 5.15^a	64.80 ± 4.90^a	-10.658 (-11.484 to -9.831)	-11.410 (-12.255 to -15.565)
Time to first faces (hour)	96.03 ± 5.14	83.68 ± 5.37^a	82.91 ± 5.47^a	-12.356 (-13.215 to -11.496)	-13.134 (-14.013 to -12.255)
Time to first oral feeding (hour)	85.02 ± 5.40	73.65 ± 4.95^a	72.88 ± 4.80^a	-11.372 (-12.187 to -10.558)	-12.141 (-12.974 to -11.308)
I-FEED score
Normal	197 (70.11)	250 (79.97)^a	221 (77.54)^a
POGI	65 (23.13)	45 (14.48)^a	43 (15.09)^a
POI	19 (6.76)	18 (5.75)	21 (7.37)

^aP < 0.05.

P compared with the control group. MD: Mean difference; CI: Confidence interval; I-FEED score: Intake, feeling nauseated, emesis, physical examination, and duration of symptoms; POGI: Postoperative gastrointestinal intolerance; POI: Postoperative ileus.

Table 4 Multiple linear regression analysis results of various factors on the time to first flatus after laparoscopic colorectal surgery in patients

Item	Simple linear regression			Multiple linear regression
Item	β value	t value	P value	β value	t value	P value
Constant	78.428	41.315	< 0.001	76.214	249.397	< 0.001
Age	-0.019	-0.925	0.355
Gender	0.009	0.026	0.979
BMI	-0.039	-0.76	0.447
ASA grading
II	0.126	0.138	0.890
III	-0.582	-0.52	0.603
Comorbidities	0.277	0.544	0.586
Site of surgery	-0.207	-0.559	0.577
Groups
Dexmedetomidine	-10.707	-25.234	< 0.001	-10.658	-25.316	< 0.001
High-dose dexmedetomidine	-0.746	-1.769	0.077	-0.752	-1.794	0.073

BMI: Body mass index; ASA: American Society of Anesthesiologists; Comorbidities: Hypertension, diabetes and coronary heart disease; Site of surgery: Proctectomy and colectomy.

Table 5 Comparison of the time to first flatus was analyzed by gender subgroups, mean ± SD

Time to first flatus (hour)	Control	Low-dose	High-dose	High-dose vs low-dose MD (95%CI)
Male	76.22 ± 5.36	65.82 ± 5.01^a^,¹	65.65 ± 5.06^a^,¹	-0.168 (-1.251 to 0.923)
Female	76.20 ± 5.27	65.22 ± 5.31^a^,¹	63.55 ± 4.38^a^,¹^,²	-1.1677 (-3.114 to 0.239)

^aP < 0.05.

¹P compared with the control group.

²P compared with low-dose group.

MD: Mean difference; CI: Confidence interval.

Table 6 Comparison of the incidence of perioperative adverse events among the three groups, n (%)

	Control (n = 281)	Low-dose (n = 313)	High-dose (n = 285)
Bradycardia	23 (8.19)	41 (13.10)	56 (19.65)^a
Tachycardia	16 (5.69)	15 (4.79)	13 (4.56)
Hypotension	31 (11.03)	39 (12.46)	40 (14.18)
Hypertension	35 (12.46)	31 (9.90)	25 (8.77)

^aP < 0.05.

P compared with the control group.

Citation: Chen Y, Tang WL, Li CT, Zhao Y, Li B, Liao LM, Lin TH, Zhang LC. Efficacy and safety of different doses of dexmedetomidine on gastrointestinal function recovery after laparoscopic colorectal surgery. World J Gastroenterol 2025; 31(31): 110582
URL: https://www.wjgnet.com/1007-9327/full/v31/i31/110582.htm
DOI: https://dx.doi.org/10.3748/wjg.v31.i31.110582