Chen Y, Tang WL, Li CT, Zhao Y, Li B, Liao LM, Lin TH, Zhang LC. Efficacy and safety of different doses of dexmedetomidine on gastrointestinal function recovery after laparoscopic colorectal surgery. World J Gastroenterol 2025; 31(31): 110582 [DOI: 10.3748/wjg.v31.i31.110582]
Corresponding Author of This Article
Liang-Cheng Zhang, PhD, Professor, Department of Anaesthesiology, Fujian Medical University Union Hospital, No. 29 Xin-Quan Road, Fuzhou 350000, Fujian Province, China. zhanglc@fjmu.edu.cn
Research Domain of This Article
Anesthesiology
Article-Type of This Article
Retrospective Cohort Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Ying Chen, Liang-Cheng Zhang, Department of Anaesthesiology, Fujian Medical University Union Hospital, Fuzhou 350000, Fujian Province, China
Ying Chen, Wen-Lu Tang, Chun-Tian Li, Yu Zhao, Bing Li, Tian-Hua Lin, Department of Anaesthesiology, Longyan First Affiliated Hospital of Fujian Medical University, Longyan 364000, Fujian Province, China
Lian-Ming Liao, Department of Laboratory Medicine, Fujian Medical University Union Hospital, Fuzhou 350000, Fujian Province, China
Co-first authors: Ying Chen and Wen-Lu Tang.
Co-corresponding authors: Tian-Hua Lin and Liang-Cheng Zhang.
Author contributions: Chen Y and Tang WL wrote the manuscript; Chen Y and Li CT collected and analyzed the data; Tang WL, Zhao Y, Li B and Zhang LC analyzed the data; Liao LM, Lin TH and Zhang LC conceived of the review and edited the manuscript; All authors read and approved the final manuscript.
Supported by the Natural Science Foundation of Fujian Province, No. 2021J011438.
Institutional review board statement: The study was approved by the Institutional Ethics Committee of Longyan First Affiliated Hospital of Fujian Medical University (No. LYREC2025-k083-01).
Informed consent statement: The informed consent was waived by the Institutional Review Board.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
STROBE statement: The authors have read the STROBE Statement—a checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-a checklist of items.
Data sharing statement: The datasets generated during and/or analyzed during the current study are available from the first author and corresponding author on reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Liang-Cheng Zhang, PhD, Professor, Department of Anaesthesiology, Fujian Medical University Union Hospital, No. 29 Xin-Quan Road, Fuzhou 350000, Fujian Province, China. zhanglc@fjmu.edu.cn
Received: June 13, 2025 Revised: July 8, 2025 Accepted: July 31, 2025 Published online: August 21, 2025 Processing time: 67 Days and 8.5 Hours
Core Tip
Core Tip: Both low-dose and high-dose dexmedetomidine enhance gastrointestinal recovery after laparoscopic colorectal surgery, significantly shortening time to first flatus, defecation, and oral intake vs controls. No dose-dependent benefit observed: High-dose dexmedetomidine (1.0 μg/kg + 0.5 μg/kg/hour) did not further accelerate gastrointestinal recovery compared to low-dose (0.5 μg/kg + 0.2 μg/kg/hour). Low-dose regimen demonstrated superior safety: High-dose dexmedetomidine significantly increased intraoperative bradycardia risk (19.15% vs 8.19% in controls, P < 0.05). Reduced opioid/sedative requirements: Dexmedetomidine groups required less propofol and remifentanil than controls, potentially mitigating opioid-induced gastrointestinal dysfunction. Clinical recommendation: Low-dose dexmedetomidine is optimal for enhancing gastrointestinal recovery while minimizing cardiovascular risks.
