Predictive value of core-fucosylated low-molecular-weight kininogen levels in patients with liver fibrosis: A prospective study

Table 1 The baseline characteristics of patients and healthy controls, mean ± SD

	Normal, n = 132	Fibrosis, n = 132	P value
Age	41.06 ± 11.91	41.89 ± 11.50	0.552
Sex, female [n (%)]	44 (33.33)	30 (22.73)	0.055
PLT	226.07 ± 64.92	144.72 ± 81.79	< 0.001
AST	25.84 ± 19.28	62.56 ± 148.45	< 0.001
ALT	35.68 ± 85.95	87.04 ± 264.16	< 0.001
ALB	48.81 ± 16.15	47.41 ± 9.69	0.936
GGT	43.52 ± 65.89	81.70 ± 179.03	< 0.001
ALP	79.34 ± 26.81	102.54 ± 64.99	0.009
TB	12.21 ± 6.27	27.82 ± 58.26	0.002
LMWK	7.17 ± 1.88	11.05 ± 3.63	< 0.001
Liver stiffness value	4.41 ± 1.35	8.75 ± 5.12	< 0.001
APRI	13.63 ± 10.72	80.37 ± 108.07	< 0.001

PLT: Platelet; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; ALB: Albumin; GGT: Gamma-glutamyl transferase; ALP: Alkaline phosphatase; TB: Total bilirubin; LMWK: Low-molecular-weight kininogen; APRI: Aminotransferase-to-platelet ratio index.

Table 2 Correlation between core-fucosylated low-molecular-weight kininogen level with the laboratory indicators

Fibrosis indicator	Correlation, r	P value
Liver stiffness value	0.5789	0.0000
PLT	-0.4404	0.0001
ALP	0.3052	0.0000
APRI	0.2180	0.1133
GGT	0.1487	0.0232
AST	0.1366	0.0367
ALT	0.0936	0.1353
ALB	-0.0315	0.6177

PLT: Platelet; ALP: Alkaline phosphatase; APRI: Aminotransferase-to-platelet ratio index; GGT: Gamma-glutamyl transferase; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; ALB: Albumin.