Serum exosomal hsa-let-7f-5p: A potential diagnostic biomarker for metastatic pancreatic cancer detection

Table 1 Demographic characteristics of patients with localized or metastatic pancreatic cancer, n (%)

Variables	Patients with metastatic pancreatic cancer (n = 17)	Patients with localized pancreatic cancer (n = 19)	P value
Age, years	64.32 ± 8.00	61.88 ± 8.92	0.3941
Gender			0.3452
Male	10 (58.8)	14 (73.7)
Female	7 (41.2)	5 (26.3)
Clinical symptoms
Abdominal pain	9 (52.9)	12 (63.2)	0.5352
Abdominal bloating or diarrhea	3 (17.6)	4 (21.1)	0.5662
Yellow urine or icterus	6 (35.3)	7 (41.2)	0.7242
Marasmus	2 (11.8)	2 (10.5)	0.6552
Asymptomatic	6 (35.3)	9 (47.4)	0.4632
Staging			< 0.0012
I	0	3
II	0	8
III	0	8
IV	17	0

¹Calculated using a t-test.

²Calculated using Fisher’s exact test or a χ² test.

Table 2 The top eight named (previously reported) differentially expressed exosomal microRNAs identified in this study

MicroRNA	log2 (FC)	P value	microRNA_seq	Regulation
hsa-let-7f-5p	7.735016707	0.000929468	TGAGGTAGTAGATTGTATAGTT	Up
hsa-miR-150-5p	7.14531257	0.007156657	AACCCGTAGATCCGAACTTGTG	Up
hsa-miR-15b-5p	1.118971956	0.026993311	TCGAGGAGCTCACAGTCT	Up
hsa-miR-151a-3p	1.0528602	0.015206751	CAACGGAATCCCAAAAGCAGCTG	Up
hsa-miR-200b-3p	-0.675276934	0.038884084	TAATACTGCCTGGTAATGATGA	Down
hsa-miR-200b-5p	-1.12850605	0.000277183	CATCTTACTGGGCAGCATTGGA	Down
hsa-miR-203b-5p	-7.79645688	0.013200973	TAGTGGTCCTAAACATTTCACA	Down
hsa-miR-204-3p	-8.83325841	0.000617642	GCTGGGAAGGCAAAGGGACGT	Down

FC: Fold change.