Efficacy and safety of sirolimus in the treatment of gastrointestinal angiodysplasias

Table 1 Clinical effectiveness scoring system for sirolimus treatment

Score	0	1	2	3	4
Bleeding episode	0	1	2-3	4-6	> 6
Duration of bleeding (days)	0	≤ 7	8-30	31-60	> 60
Hb (g/L)	≥ 120	90-120	60-90	30-60	< 30
Blood transfusion (mL)	0	≤ 200	200-400	400-800	> 800
Severity of dizziness and fatigue	None	Mild, does not affect work or daily life	Moderate, partially affects work and daily life	Severe, significantly affects work and daily life	Incapacitating, unable to perform daily work and life activities, requires symptomatic treatment
Duration of dizziness and fatigue (days)	0	≤ 15	15-30	30-45	> 45

Hb: Hemoglobin.

Table 2 Patients’ principal characteristics, management, and adverse events

No.	Gender	Age	Disease course	Clinical symptoms	Comorbidities	Past treatment	Dosage of sirolimus	Adverse events
1	Female	66	3 years	Melena	None	Endoscopic	2 mg, q.d.	Mouth ulcers, diarrhea
2	Female	62	6 months	Melena	Bronchial asthma		2 mg, q.d.	Elevated triglycerides
3	Male	49	14 years	Hematochezia	None	Surgery	1 mg, q.d.	Pulmonary infection
4	Female	64	5 years	Melena	Hypertension, bronchial asthma, mitral regurgitation	Endoscopic	2 mg, q.d.	Diarrhea
5	Male	48	11 months	Melena	Hypertension, pituitary tumor, multiple hepatic hemangiomas	Endoscopic	1 mg, q.d.	None
6	Female	68	1 year	Hematochezia	Hypertension, type 2 diabetes		2 mg, q.d.	Mouth ulcers
7	Female	70	20 months	Melena	Aortic valve stenosis with regurgitation, mitral stenosis		2 mg, q.d.	None
8	Female	39	9 years	Melena	None	Endoscopic, Surgery	2 mg, q.d.	Mouth ulcers
9	Male	52	2 years	Melena	Old cerebral infarction		2 mg, q.d.	Mouth ulcers, rash
10	Female	73	8 months	Melena	Pulmonary emphysema		1.5 mg, q.d.	None
11	Female	74	2 years	Melena	Pulmonary emphysema; atrial fibrillation		1 mg, q.d.	None

q.d.: Quaque die.

Table 3 Median transfusion volume before and after sirolimus treatment

Blood transfusions (mL)	Pre-sirolimus	Post-sirolimus	Z value	P value
3 months	400 (0, 5000)	0 (0, 1200)	-2.823	0.005
6 months	800 (400, 10400)	0 (0, 2300)	-2.807	0.005