Analysis of lactate dehydrogenase activities and isoenzyme patterns in colorectal cancer tissues

Table 1 Lactate dehydrogenase activities in colorectal cancer tissues and adjacent noncancerous tissues (¯x ± s)

Tissues	n	Total activities (u/g tissue)	Specific activities (u/mg protein)
Cancer tissue	16	62.70 ± 13.50	63.41 ± 12.41
Adjacent Control
Proximal tissue	16	43.15 ± 22.95d	38.22 ± 19.77b
Distal tissue	16	44.81 ± 17.24b	39.92 ± 15.15b

^bP < 0.01,

^dP < 0.01 vs cancer tissue

Table 2 Lactate dehydrogenase isoenzyme patterns in colorectal cancer tissues and adjacent noncancerous tissues (¯x ± s)

Tissues	n	LDH isoenzyme (%)					LDH4 + LDH5/LDH1 + LDH2
		1	2	3	4	5
Cancer tissue	16	1.65 ± 1.42	15.54 ± 3.80	26.59 ± 6.25	36.63 ± 6.80	19.13 ± 8.05	3.6 ± 1.4
Adjacent control
Proximal tissue	16	4.93 ± 6.19	19.18 ± 5.29a	30.05 ± 4.04	37.03 ± 8.24	8.76 ± 6.04e	2.3 ± 1.2a
Distal tissue	16	4.28 ± 2.55b	22.17 ± 4.57b	34.38 ± 5.75e	30.76 ± 5.83a	8.11 ± 6.32e	1.7 ± 0.9e

^aP < 0.05,

^bP < 0.01,

^eP < 0.001 vs cancer tissue. LDH: lactate dehydrogenase.