Roles of phosphatidylinositol-3-kinases signaling pathway in inflammation-related cancer: Impact of rs10889677 variant and buparlisib in colitis-associated cancer

doi:10.3748/wjg.v29.i40.5543

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Oct 28, 2023 (publication date) through Nov 6, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Oct 28, 2023; 29(40): 5543-5556
Published online Oct 28, 2023. doi: 10.3748/wjg.v29.i40.5543

Table 1 Clinical and demographic details of the recruited patients

	CRC (n = 15)	CAC (n = 7)	UC (n = 10)
Median age (range)	63 (39-67)	58 (20-71)	65 (52-69)
Race
Malay	11	2	5
Chinese	4	2	3
Indian	-	3	2
Gender
Male	9	3	4
Female	6	4	6
Smoking status
Smoker/Ex-smoker	2	1	-
Non-smoker	13	6	10
Stage¹
I	2	1	Not applicable
II	-	-
III	7	4
Adenocarcinoma types¹
Poorly differentiated	-	1	Not applicable
Moderately differentiated	7	1
Well differentiated	1	3
Mayo score (range)¹	Not applicable	Data unavailable	1-3
Geboes score (range)¹	Not applicable	Data unavailable	2A.1-2A.2
Presentation	Rectal bleeding	Rectal bleeding, abdominal pain, severe diarrhea	Diarrhea, loss of appetite

¹Some data are unavailable.

All data are expressed as n except where indicated in the table. UC: Ulcerative colitis; CRC: Colorectal cancer; CAC: Colitis-associated cancer.

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Citation: Razali NN, Raja Ali RA, Muhammad Nawawi KN, Yahaya A, Mohd Rathi ND, Mokhtar NM. Roles of phosphatidylinositol-3-kinases signaling pathway in inflammation-related cancer: Impact of rs10889677 variant and buparlisib in colitis-associated cancer. World J Gastroenterol 2023; 29(40): 5543-5556
URL: https://www.wjgnet.com/1007-9327/full/v29/i40/5543.htm
DOI: https://dx.doi.org/10.3748/wjg.v29.i40.5543