γ-aminobutyric acid B2 receptor: A potential therapeutic target for cholangiocarcinoma in patients with diabetes mellitus

Table 1 Univariate analysis of γ-aminobutyric acid B2 receptor expression and clinicopathological characteristics of cholangiocarcinoma patients

Clinicopathological data	GABBR2 expression		P value
	High (IHC index ≥ 8)	Low (IHC index < 8)
Diabetic status
DM	13	2	0.109
Non-DM	8	7
Sex
Male	10	6	0.580
Female	8	3
Survival
≥ 5 mo	14	6	1.000
< 5 mo	7	3
Histological type
Papillary	4	6	0.030a
Non-papillary	17	3
Histological grading
Well differentiated	13	7	0.672
Moderately differentiated	5	1
Poorly differentiated	3	1
Tumor size (longest diameter)
> 7 cm	6	7	0.020a
≤ 7 cm	15	2
Regional lymph node involvement
Yes	10	8	0.543
No	8	4
Distant metastasis
Metastasis	14	4	0.418
Non-metastasis	7	5

^aP < 0.05.

GABBR2: γ-aminobutyric acid B2 receptor.