Recent advances and current challenges in endoscopic resection with the full-thickness resection device

Table 1 Summary of major clinical studies with current applications of full-thickness resection device for endoscopic full-thickness resection

	Ref.	Study type	Total FTRD cases, n	Site (s)	Type of lesion	Technical success, %	R0 resection, %	Full-thickness resection, %	Adverse events, %
1	Schmidt et al[19]	Retrospective	24	Colon; Rectum	Non-lifting polyps (n = 13); Appendiceal polyps (n = 5); Diagnostic (n = 3); Subepithelial tumor (n = 2); Polyp involving diverticulum (n = 1)	83.3	75.0	87.5	8.3
2	Schmidt et al[25]	Prospective	181	Colon; Rectum	Difficult adenomas (79.0%); Cancer (8.3%); Subepithelial tumor (12.7%)	89.5	76.9	81.0	9.9
3	Meier et al[12]	Retrospective	1178	Colon; Rectum	Difficult adenomas (67.1%); Cancer (18.4%); Subepithelial tumor (6.8%); Diagnostic (1.3%)	88.2	80.0	89.9	12.1
4	Boger et al[23]	Retrospective	68	Colon; Rectum	Non-lifting polyps (n = 29); Cancer (n = 13); Subepithelial tumor (n = 9); Polyps in appendix or diverticulum (n = 17)	88.2	76.8	NA	5.9
5	Hajifathalian et al[37]	Retrospective	56	Stomach; Duodenum	Mesenchymal neoplasm including GIST (n = 26); Diagnostic (n = 10), NET (n = 9); Adenomas (n = 6); Adenocarcinoma (n = 5)	93.0	68.0	NA	21.0
6	Meier et al[39]	Prospective	29	Stomach	Subepithelial tumor (n = 29)	89.7	76.0	65.5	31.0
7	Ichkhanian et al[20]	Retrospective	66	Colon/appendiceal orifice	Polyps involving appendiceal orifice	89.0	93.0	91.0	17.0
8	Zwager et al[28]	Prospective	367	Colon; Rectum	Difficult polyps (n = 133); T1 cancer (n = 71); Incomplete resection (n = 150); Subepithelial tumors (n = 13)	83.9	82.4	83.2	9.3
9	Zwager et al[29]	Retrospective	330	Colon; Rectum	Primary resection of T1 cancer (n = 132); Secondary resection of T1 cancer (n = 198)	87.0	85.6	NA	2.2

FTRD: Full-thickness resection device; GIST: Gastrointestinal stromal tumors; NA: Not available; NET: Neuroendocrine tumor.