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World J Gastroenterol. Jul 7, 2023; 29(25): 4009-4020
Published online Jul 7, 2023. doi: 10.3748/wjg.v29.i25.4009
Recent advances and current challenges in endoscopic resection with the full-thickness resection device
Elijah J Mun, Mihir S Wagh
Elijah J Mun, Division of Gastroenterology, University of Colorado School of Medicine, Aurora, CO 80045, United States
Mihir S Wagh, Interventional Endoscopy, Division of Gastroenterology, University of Colorado School of Medicine, Aurora, CO 80045, United States
Author contributions: Mun EJ contributed drafting of the manuscript; Wagh MS contributed critical review of the manuscript and endoscopic image acquisition.
Conflict-of-interest statement: Dr. Mun discloses no conflict of interest for this article; Dr. Wagh is consultant for Boston Scientific, Olympus, Medtronic, Fujifilm and ConMed.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Mihir S Wagh, FACG, FASGE, MD, Professor, Interventional Endoscopy, Division of Gastroenterology, University of Colorado School of Medicine, 1635 Aurora Court, F735, Aurora, CO 80045, United States. mihir.wagh@cuanschutz.edu
Received: February 10, 2023
Peer-review started: February 10, 2023
First decision: March 15, 2023
Revised: March 27, 2023
Accepted: June 5, 2023
Article in press: June 5, 2023
Published online: July 7, 2023
Processing time: 138 Days and 6.7 Hours
Abstract

Endoscopic full-thickness resection (EFTR) has emerged as a viable technique in the management of mucosal and subepithelial lesions of the gastrointestinal tract (GIT) not amenable to conventional therapeutic approaches. While various devices and techniques have been described for EFTR, a single, combined full-thickness resection and closure device (full-thickness resection device, FTRD system, Ovesco Endoscopy AG, Tuebingen, Germany) has become commercially available in recent years. Initially, the FTRD system was limited to use in the colorectum only. Recently, a modified version of the FTRD has been released for EFTR in the upper GIT as well. This review provides a broad summary of the FTRD, highlighting recent advances and current challenges.

Keywords: Endoscopic full-thickness resection; Full-thickness resection device; Colorectal neoplasm; Subepithelial lesions; Scarred non-lifting polyps

Core Tip: Endoscopic full-thickness resection (EFTR) is an emerging technique for tissue resection of lesions in the gastrointestinal tract (GIT) not amenable to conventional resection approaches. The novel full-thickness resection device (FTRD) is a combined full-thickness resection and closure device that allows for EFTR of lesions in the GIT. EFTR with FTRD is feasible, safe, and efficacious and should be considered as a viable option for resection of select lesions in the lower and upper GIT.