Knockdown of DEAD-box 51 inhibits tumor growth of esophageal squamous cell carcinoma via the PI3K/AKT pathway

Table 1 Correlation of DDX51 expression with the clinicopathologic features of ESCC patients

Characteristics	Cases (n = 118)	DDX51 expression level		P value
		Low (n = 52)	High (n = 66)
Age (yr)				0.740
< 50	30	14	16
≥ 50	88	38	50
Gender				0.201
Male	91	43	48
Female	27	9	18
Tumor size				0.194
< 30 mm	20	12	8
30-50 mm	66	29	37
≥ 50 mm	32	11	21
Differentiation degree				0.025a
High	26	11	15
Moderate	53	30	23
Low	39	11	28
pT				0.154
T1	8	6	2
T2	51	23	28
T3 + T4	59	23	36
pN				0.012a
N0	42	25	17
N1 + N2	76	27	49
pTNM				0.002a
I + II	37	24	13
III + IV	81	28	53

^aP < 0.05 indicated statistical significance. Statistical analysis was performed using the chi-square test. TNM: Tumor-node-metastasis.

Table 2 Comparison of Kaplan–Meier survival curves

	B	SE	Wald	P value	HR	95%CI
Differentiation	0.052	0.157	0.110	0.740	1.053	0.774-1.433
pN	0.029	0.451	0.004	0.949	1.029	0.425-2.491
pTNM	1.078	0.518	4.323	0.038	2.939	1.064-8.119
DDX51	0.893	0.241	13.686	< 0.01	2.443	1.522-3.921