Basic Study
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jan 28, 2022; 28(4): 464-478
Published online Jan 28, 2022. doi: 10.3748/wjg.v28.i4.464
Knockdown of DEAD-box 51 inhibits tumor growth of esophageal squamous cell carcinoma via the PI3K/AKT pathway
Dong-Xin Hu, Qi-Feng Sun, Lin Xu, Hong-Da Lu, Fan Zhang, Zhen-Miao Li, Ming-Yan Zhang
Dong-Xin Hu, Qi-Feng Sun, Lin Xu, Hong-Da Lu, Fan Zhang, Zhen-Miao Li, Department of Thoracic Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250000, Shandong Province, China
Ming-Yan Zhang, Department of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250000, Shandong Province, China
Author contributions: Hu DX, Sun QF, Xu L, Li ZM, Lu HD, and Zhang F contributed to the material preparation, data collection and analyses; Hu DX and Zhang MY contributed to the first draft; All authors contributed to the study conception and design, commented on previous versions of the manuscript, and read and approved the final manuscript.
Supported by the Natural Science Foundation of Shandong Province, No. ZR2020QH194.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of Shandong Provincial Hospital Affiliated to Shandong First Medical University.
Institutional animal care and use committee statement: All animal experiments were approved with Shandong Provincial Hospital Affiliated to Shandong First Medical University.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ming-Yan Zhang, MD, Associate Chief Physician, Department of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No. 324, Jingwuwei Seventh Road, Huaiyin District, Jinan 250000, Shandong Province, China. zhangmingyan@sdfmu.edu.cn
Received: August 8, 2021
Peer-review started: August 8, 2021
First decision: November 7, 2021
Revised: November 15, 2021
Accepted: January 6, 2022
Article in press: January 6, 2022
Published online: January 28, 2022
Processing time: 166 Days and 22.7 Hours
Core Tip

Core Tip: Our study revealed that DEAD-box helicase 51 was upregulated in esophageal squamous cell carcinoma (ESCC) tumor tissues and promoted tumor proliferation and development by upregulating the phosphorylation of phosphoinositide 3-kinase/AKT pathway members. These data extend our knowledge of the function and molecular mechanism of the DEAD-box family in tumor biology and provide a potential therapeutic target for ESCC treatment.