Fabian O, Bajer L. Histopathological assessment of the microscopic activity in inflammatory bowel diseases: What are we looking for? World J Gastroenterol 2022; 28(36): 5300-5312 [PMID: 36185628 DOI: 10.3748/wjg.v28.i36.5300]
Corresponding Author of This Article
Ondrej Fabian, MD, PhD, Assistant Professor, Postdoc, Clinical and Transplant Pathology Centre, Institute for Clinical and Experimental Medicine, Videnska 1958/9, Prague 14021, Czech Republic. ondrej.fabian@ikem.cz
Research Domain of This Article
Pathology
Article-Type of This Article
Minireviews
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0 = No erosion, ulceration or granulation tissue; 1 = Recovering epithelium + adjacent inflammation; 2 = Probable erosion-focally stripped; 3 = Unequivocal erosion; 4 = Ulcer or granulation tissue
Table 4 Nancy histological index
Grade
Criteria
Grade 0 (no histological significant disease)
No or mild increase in chronic inflammatory infiltrate
Grade 1 (chronic inflammatory infiltrate with no acute inflammatory infiltrate)
Moderate or marked increase in chronic inflammatory infiltrate that is easily apparent. No acute inflammatory infiltrate is present
Grade 2 (mildly active disease)
Few or rare neutrophils in lamina propria or in the epithelium that are difficult to see
Grade 3 (moderately active disease)
Presence of multiple clusters of neutrophils in lamina propria and/or in epithelium that are easily apparent
Grade 4 (severely active disease)
Loss of colonic crypts replaced with “immature” granulation tissue (disorganized blood vessels with extravasated neutrophils) or the presence of fibrinopurulent exudate
0 = Normal; 1 = Two or more neutrophils in lamina propria in one high-power field and/or any presence of intraepithelial neutrophils; 2 = Crypt abscesses, erosions, ulcers
Citation: Fabian O, Bajer L. Histopathological assessment of the microscopic activity in inflammatory bowel diseases: What are we looking for? World J Gastroenterol 2022; 28(36): 5300-5312