Simple cholecystectomy is an adequate treatment for grade I T1bN0M0 gallbladder carcinoma: Evidence from 528 patients

Table 1 General characteristics and survival data for 528 patients with T1b gallbladder cancer

Characteristics	n = 528, n (%)	10-year survival
		OS, %	DSS, %
Age, yr
< 70	220 (41.7)	46.4%	62.7%
≥ 70	308 (58.3)	21.9%	58.9%
		P < 0.001	P = 0.023
Gender
Male	143 (27.1)	13.7	47.5
Female	385 (72.9)	37.8	64
		P = 0.007	P = 0.016
Grade
Grade I	161 (30.5)	33.1	64.7
Grade II	269 (50.9)	32.6	62.1
Grade III, IV	98 (18.6)	28.6	48.9
		P = 0.056	P = 0.002
Histological type
Adenocarcinoma	387 (73.3)	30.5	61.6
Papillary	79 (15.0)	40.2	61.8
Other	62 (11.7)	29	51
		P = 0.059	P = 0.058
Surgery
SC	346 (65.5)	27.8	55.1
SC + LN	131 (24.8)	35.5	66.3
RC	51 (9.7)	50.3	75.9
		P < 0.001	P = 0.002

OS: Overall survival; DSS: Disease-specific survival; SC: Simple cholecystectomy; LN: Lymph node resection; RC: Radical cholecystectomy; N: Number.

Table 2 Multivariate Cox proportional hazards model for 10-year overall survival and disease-specific survival in 528 patients with T1b gallbladder cancer

Variable	10-year overall survival		10-year disease-specific survival
	HR (95%CI)	P value	HR (95%CI)	P value
Age, yr
< 70	Referent		Referent
≥ 70	2.03 (1.57-2.63)	< 0.001	NA	NA
Gender
Male	Referent		Referent
Female	0.71 (0.55-0.91)	0.007	0.62 (0.45-0.87)	0.005
Grade
Grade I	Referent		Referent
Grade II	NA	NA	1.21 (0.83-1.76)	0.321
Grade III, IV	NA	NA	2.20 (1.43-3.38)	< 0.001
Histological type
Adenocarcinoma	Referent		Referent
Papillary	NA	NA	NA	NA
Other	NA	NA	NA	NA
Surgery
SC	Referent		Referent
SC + LN	0.71 (0.53-0.95)	0.020	0.56 (0.37-0.83)	0.004
RC	0.54 (0.32-0.89)	0.015	0.49 (0.27-0.92)	0.025

SC: Simple cholecystectomy; LN: Lymph node resection; RC: Radical cholecystectomy; N: Number; HR: Hazard ratio; CI: Confidence interval; NA: Not available.

Table 3 General characteristics and survival data for 161 patients with grade I T1b gallbladder cancer

Characteristics	n = 161, n (%)	10-year survival
		OS, %	DSS, %
Age, yr
< 70	72 (41.7)	65.8	70.6
≥ 70	89 (58.3)	58.0	79.1
		P = 0.0221	P = 0.431
Gender
Male	49 (27.1)	54.6	72.6
Female	112 (72.9)	63.6	75.9
		P = 0.0301	P = 0.071
Histological type
Adenocarcinoma	116 (73.3)	62.8	76.2
Papillary	32 (15.0)	60.1	74.6
Other	13 (11.7)	46.2	60.6
		P = 0.799	P = 0.562
Surgery
SC	105 (65.5)	60.1	76.1
SC + LN	41 (24.8)	65.2	75.3
RC	15 (9.7)	56.6	67.0
		P = 0.734	P = 0.953

¹P < 0.05.

OS: Overall survival; DSS: Disease-specific survival; SC: Simple cholecystectomy; LN: Lymph node resection; RC: Radical cholecystectomy; N: Number.

Table 4 Multivariate Cox proportional hazards model for 10-year overall survival and disease-specific survival in 161 patients with grade I T1b gallbladder cancer

Variable	10-year overall survival		10-year disease-specific survival
	HR (95%CI)	P value	HR (95%CI)	P value
Age, yr
< 70	Referent		Referent
≥ 70	1.67 (1.07-2.59)	0.023	NA	NA
Gender
Male	Referent		Referent
Female	0.62 (0.40-0.96)	0.031	NA	NA
Histological type
Adenocarcinoma	Referent		Referent
Papillary	NA	NA	NA	NA
Other	NA	NA	NA	NA
Surgery
SC	Referent		Referent
SC + LN	NA	NA	NA	NA
RC	NA	NA	NA	NA

SC: Simple cholecystectomy; LN: Lymph node resection; RC: Radical cholecystectomy; N: Number; HR: Hazard ratio; CI: Confidence interval; NA: Not available.