Shao J, Lu HC, Wu LQ, Lei J, Yuan RF, Shao JH. Simple cholecystectomy is an adequate treatment for grade I T1bN0M0 gallbladder carcinoma: Evidence from 528 patients. World J Gastroenterol 2022; 28(31): 4431-4441 [PMID: 36159006 DOI: 10.3748/wjg.v28.i31.4431]
Corresponding Author of This Article
Jiang-Hua Shao, MD, PhD, Chief Doctor, Full Professor, Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Nanchang University, No. 1 Minde Road, Nanchang 330006, Jiangxi Province, China. shao5022@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Observational Study
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Shao J, Lu HC, Wu LQ, Lei J, Yuan RF, Shao JH. Simple cholecystectomy is an adequate treatment for grade I T1bN0M0 gallbladder carcinoma: Evidence from 528 patients. World J Gastroenterol 2022; 28(31): 4431-4441 [PMID: 36159006 DOI: 10.3748/wjg.v28.i31.4431]
World J Gastroenterol. Aug 21, 2022; 28(31): 4431-4441 Published online Aug 21, 2022. doi: 10.3748/wjg.v28.i31.4431
Simple cholecystectomy is an adequate treatment for grade I T1bN0M0 gallbladder carcinoma: Evidence from 528 patients
Jun Shao, Hong-Cheng Lu, Lin-Quan Wu, Jun Lei, Rong-Fa Yuan, Jiang-Hua Shao
Jun Shao, Hong-Cheng Lu, Lin-Quan Wu, Jun Lei, Rong-Fa Yuan, Jiang-Hua Shao, Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China
Author contributions: Shao J and Lu HC contributed equally to this work; Shao J, Shao JH, and Lu HC were involved in study concept and design, drafting of the manuscript and study supervision; Wu LQ contributed to collect data; Lei J and Yuan RF contributed to analyze the data; Shao JH, Shao J, and Lu HC critically revise the manuscript; all authors have read and approve the final manuscript.
Supported bythe National Natural Science Foundation of China, No. 81773126, No. 81560475, and No. 82160486.
Institutional review board statement: The study was reviewed and approved by the Second Affiliated Hospital of Nanchang University Institutional Review Board, No. 74.
Informed consent statement: Patients from the Surveillance, Epidemiology, and End Results (SEER) database consented to participate in any scientific research worldwide.
Conflict-of-interest statement: There are no conflicts of interest to report.
Data sharing statement: The datasets used or analyzed in this study are available from the corresponding author at shao5022@163.com. Patients from the Surveillance, Epidemiology, and End Results (SEER) database consented to participate in any scientific research worldwide.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Corresponding author: Jiang-Hua Shao, MD, PhD, Chief Doctor, Full Professor, Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Nanchang University, No. 1 Minde Road, Nanchang 330006, Jiangxi Province, China. shao5022@163.com
Received: April 21, 2022 Peer-review started: April 21, 2022 First decision: May 30, 2022 Revised: June 12, 2022 Accepted: July 25, 2022 Article in press: July 25, 2022 Published online: August 21, 2022 Processing time: 117 Days and 3 Hours
ARTICLE HIGHLIGHTS
Research background
The surgical treatment of T1b gallbladder cancer has been controversial.
Research motivation
To solve the problem of choosing the surgical treatment for T1b gallbladder cancer.
Research objectives
To explore the optimal surgical approach in patients with T1b gallbladder cancer of different pathological grades.
Research methods
Analysis of survival differences in patients with different pathological grades of T1b gallbladder cancer who received different surgical treatment methods.
Research results
Patients with grade I T1b gallbladder cancer who underwent simple cholecystectomy attained a survival benefit equivalent to that of simple cholecystectomy with lymph node resection or radical cholecystectomy.
Research conclusions
Simple cholecystectomy is an adequate treatment for grade I T1b gallbladder carcinoma (GBC), whereas expanded radical resection is more suitable for grade II-IV T1b GBC.
Research perspectives
Simple cholecystectomy is a suitable treatment for patients with grade I T1b GBC.
