Copyright
©The Author(s) 2021.
World J Gastroenterol. Aug 21, 2021; 27(31): 5259-5271
Published online Aug 21, 2021. doi: 10.3748/wjg.v27.i31.5259
Published online Aug 21, 2021. doi: 10.3748/wjg.v27.i31.5259
Characteristics | Intestinal GC | Mucinous GC | Diffuse GC | Total | P value |
Number | 31 | 4 | 15 | 50 | |
Age | 56.3 11.2 | 51.3 7.37 | 46.0 18.3 | 52.8 13.7 | 0.174 |
Sex, n (%) | 0.738 | ||||
Males | 18 (58.1) | 3 (75) | 8 (53.5) | 29 (58) | |
Females | 13 (41.9) | 1 (25) | 7 (46.7) | 21 (42) | |
Stage, n (%) | 0.33 | ||||
Stage 2 | 2 (6.5) | 0 | 0 | 2 (4) | |
Stage 3 | 13 (41.9) | 1 (25) | 6 (40) | 20 (40) | |
Stage 4 | 16 (51.6) | 3 (75) | 9 (60) | 28 (56) | |
Grade, n (%) | - | - | |||
G1 | 5 (16.1) | ||||
G2 | 11 (35.5) | ||||
G3 | 15 (48.4) | ||||
MMR status | |||||
MSI | 2 | - | - | 2 | |
MSS | 29 | 4 | 15 | 48 |
Characteristics | CD8+ cells | CD68+ cells | CD163+ cells | |||
TC | TS | TC | TS | TC | TS | |
Histological type | ||||||
Intestinal | 214 ± 44.9 | 202 ± 14.7 | 303 ± 21.7 | 244 ± 12.4 | 173 ± 17.3 | 170 ± 9.67 |
124-305 | 173-232 | 259-347 | 219-269 | 138-208 | 151-190 | |
Diffuse | 49.5 ± 6.63 | 66.0 ± 6.03 | 339 ± 23.6 | 225 ± 23.8 | 51.7 ± 8.60 | 55.5 ± 8.94 |
36.0-63.1 | 43.6-98.3 | 291-388 | 176-274 | 34.1-69.4 | 37.2-73.9 | |
Mucinous | 7.53 ± 2.50 | 52.5 ± 37.5 | 101 ± 59.0 | 219 ± 16.2 | 12.5 ± 11.8 | 62.5 ± 12.5 |
2.26-34.3 | 23.9-82.9 | 64-125 | 126-264 | 6.32-78.2 | 36-121 | |
P = 0.045 | P = 0.059 | P = 0.071 | P = 0.471 | P = 0.032 | P = 0.011 | |
TIME type | ||||||
ID | 43.7 ± 4.05 | 43.2 ± 5.93 | 367.5 ± 36.9 | 213.1 ± 35.9 | 72.5 ± 18.3 | 48.7 ± 10.5 |
35.1-52.3 | 30.6-55.7 | 288-446 | 135-290 | 33.2-111 | 26.2-71.2 | |
IE | 19.4 ± 3.43 | 112 ± 15.2 | 157.3 ± 29.6 | 266.6 ± 25.8 | 55.5 ± 13.6 | 119.5 ± 16.3 |
12.2-26.7 | 80.1-144 | 94.5-220 | 211-321 | 26.5-84.4 | 84.9-154.1 | |
Inflamed | 229 ± 44.9 | 190 ± 16.5 | 352.8 ± 15.6 | 232.6 ± 13.7 | 165.6 ± 18.2 | 151.3 ± 12.1 |
138-319 | 156-223 | 321-384 | 204-260 | 128-202 | 126-175 | |
P = 0.042 | P = 0.004 | P = 0.674 | P = 0.060 | P = 0.024 | P = 0.011 | |
Status PD-L1 expression | ||||||
Positive | 341 ± 72.3 | 204 ± 52.7 | 430 ± 27.7 | 200 ± 8.19 | 231 ± 54.3 | 135 ± 29.5 |
66.3-488 | 58.4-350 | 341-518 | 174-226 | 58.4-404 | 41.3-229 | |
Negative | 49.0 ± 13.1 | 116 ± 20.7 | 261 ± 41.4 | 279 ± 37.9 | 96.3 ± 28.0 | 131 ± 28.2 |
20.1-77.9 | 72.0-159 | 169-352 | 195-362 | 34.6-157 | 69.5-193 | |
P = 0.010 | P = 0.075 | P = 0.252 | P = 0.715 | P = 0.032 | P = 0.260 |
Characteristics | ID TIME | IE TIME | Inf TIME | Total number |
Histological types of GC, n (%) | ||||
Intestinal | 1 (3.2) | 5 (16.1) | 25 (80.7) | 31 (62) |
Diffuse | 8 (53.3) | 5 (33.3) | 2 (13.3) | 15 (30) |
Mucinous | 1 (25) | 3 (75) | 0 | 4 (8) |
P < 0.001 | ||||
PD-L1 expression status, n (%) | ||||
PD-L1 positive GCs | 1 (5.6) | 0 | 8 (94.4) | 9 (18) |
PD-L1 negative GCs | 9 (21.9) | 13 (31.8) | 19 (46.3) | 41 (82) |
Total number | 10 | 13 | 27 | 50 |
P < 0.001 |
- Citation: Mashukov A, Shapochka D, Seleznov O, Kobyliak N, Falalyeyeva T, Kirkilevsky S, Yarema R, Sulaieva O. Histological differentiation impacts the tumor immune microenvironment in gastric carcinoma: Relation to the immune cycle. World J Gastroenterol 2021; 27(31): 5259-5271
- URL: https://www.wjgnet.com/1007-9327/full/v27/i31/5259.htm
- DOI: https://dx.doi.org/10.3748/wjg.v27.i31.5259