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©The Author(s) 2021.
World J Gastroenterol. Jun 14, 2021; 27(22): 3130-3137
Published online Jun 14, 2021. doi: 10.3748/wjg.v27.i22.3130
Published online Jun 14, 2021. doi: 10.3748/wjg.v27.i22.3130
Table 1 Clinical and biochemical characteristics of coronavirus disease 2019 patients with and without diarrhea, n (%)
| Overall, n = 51 | Patients with diarrhea, n = 10 | Patients without diarrhea, n = 41 | Significance | |
| Gender, male | 40 (78.4) | 8 (80) | 32 (78) | NS |
| Age | 64 (57; 71) | 63 (56; 70) | 65 (57; 71) | NS |
| Hypertension | 34 (66.6) | 6 (60) | 28 (68.3) | NS |
| Heart disease | 13 (25.5) | 4 (40) | 9 (21.9) | NS |
| Diabetes | 13 (25.5) | 2 (20) | 11 (26.8) | NS |
| COPD | 5 (9.8) | 1 (10) | 4 (9.75) | NS |
| CKD | 5 (9.8) | 1 (10) | 4 (9.75) | NS |
| Active smokers | 2 (3.9) | 1 (10) | 1 (2.4) | NS |
| Obesity | 13 (25.5) | 2 (20) | 11 (26.8) | NS |
| WBC (cell count/μL) | 6730 (5256; 9110) | 6595 (4672; 7420) | 6730 (5420; 9480) | NS |
| Neutrophils (cell count/μL) | 5455 (3700; 7760) | 5310 (3112; 6527) | 5310 (3112; 6725) | NS |
| CRP (mg/L) | 74 (27; 131) | 73 (25; 161) | 74 (29; 127) | NS |
| D-dimer (ng/mL FEU) | 720 (545; 1061) | 710 (560; 1511) | 720 (540; 1060) | NS |
| Fecal calprotectin(mg/kg) | 60 (21.5; 108) | 58 (31; 75) | 64 (18; 108) | NS |
| Fecal-RNA detection (n = positive) | 39 (76.5) | 10 (100) | 29 (70.8) | NS |
| Deceased | 3 (5.9) | 1 (10) | 2 (4.8) | NS |
| Hospital stay | 5 (2.5; 8) | 5 (2.75; 6.75) | 5 (3; 9.25) | NS |
Table 2 Clinical and biochemical characteristics of coronavirus disease 2019 patients with and without severe acute respiratory syndrome coronavirus 2 fecal detection, n (%)
| Overall, n = 51 | Patients without fecal SARS-CoV-2, n = 12 | Patients with fecal SARS-CoV-2, n = 39 | Significance | |
| Gender, male | 40 (78.4) | 12 (100) | 28 (71.8) | NS |
| Age | 64 (57; 71) | 62 (57; 68) | 65 (56; 72) | NS |
| Hypertension | 34 (66.6) | 6 (50) | 28 (71.8) | NS |
| Heart disease | 13 (25.5) | 1 (8.3) | 12 (30.8) | NS |
| Diabetes | 13 (25.5) | 2 (16.6) | 11 (28.2) | NS |
| COPD | 5 (9.8) | 0 (0) | 5 (12.8) | NS |
| CKD | 5 (9.8) | 1 (8.3) | 4 (10.25) | NS |
| Active smokers | 2 (3.9) | 1 (8.3) | 1 (2.6) | NS |
| Obesity | 13 (25.5) | 0 (0) | 13 (33.3) | P = 0.021 |
| WBC (cell count/μL) | 6730 (5256; 9110) | 6105 (4870; 8400) | 7110 (5525; 9115) | P = 0.038 |
| Neutrophils (cell count/μL) | 5455 (3700; 7760) | 4390 (3485; 7417) | 5550 (3965; 8110) | P = 0.035 |
| CRP (mg/L) | 74 (27; 131) | 113 (88; 150) | 58 (24.5; 125) | P = 0.029 |
| D-dimer (ng/Ml FEU) | 720 (545; 1061) | 580 (402; 791) | 723 (562; 1157) | P = 0.011 |
| Fecal calprotectin (mg/kg) | 60 (21.5; 108) | 39 (14; 71) | 74 (29; 132.5) | P < 0.001 |
| Diarrhea | 41 (80.4) | 0 (0) | 29 (74.35) | P < 0.001 |
| Deceased | 3 (5.9) | 0 (0) | 3 (7.7) | NS |
| Hospital stay | 5 (2.5; 8) | 3 (2; 5) | 5 (3; 9.75) | NS |
- Citation: Zerbato V, Di Bella S, Giuffrè M, Jaracz AW, Gobbo Y, Luppino D, Macor P, Segat L, Koncan R, D'Agaro P, Valentini M, Crocé LS, Ruscio M, Luzzati R. High fecal calprotectin levels are associated with SARS-CoV-2 intestinal shedding in COVID-19 patients: A proof-of-concept study. World J Gastroenterol 2021; 27(22): 3130-3137
- URL: https://www.wjgnet.com/1007-9327/full/v27/i22/3130.htm
- DOI: https://dx.doi.org/10.3748/wjg.v27.i22.3130