Prospective Study
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 14, 2021; 27(22): 3130-3137
Published online Jun 14, 2021. doi: 10.3748/wjg.v27.i22.3130
High fecal calprotectin levels are associated with SARS-CoV-2 intestinal shedding in COVID-19 patients: A proof-of-concept study
Verena Zerbato, Stefano Di Bella, Mauro Giuffrè, Anna Wladyslawa Jaracz, Ylenia Gobbo, Diego Luppino, Paolo Macor, Ludovica Segat, Raffaella Koncan, Pierlanfranco D'Agaro, Michael Valentini, Lory Saveria Crocé, Maurizio Ruscio, Roberto Luzzati
Verena Zerbato, Anna Wladyslawa Jaracz, Ylenia Gobbo, Diego Luppino, Michael Valentini, Infectious Diseases Unit, Trieste University Hospital (ASUGI), Trieste 34125, Italy
Stefano Di Bella, Roberto Luzzati, Infectious Diseases Unit, Clinical Department of Medical, Surgical and Health Sciences, Trieste University, Trieste 34123, Italy
Mauro Giuffrè, Lory Saveria Crocé, Liver Unit, Clinical Department of Medical, Surgical and Health Sciences, Trieste University, Trieste 34127, Italy
Paolo Macor, Department of Life Sciences, Trieste University, Trieste 34127, Italy
Ludovica Segat, Raffaella Koncan, Pierlanfranco D'Agaro, Department of Hygiene and Public Health Unit, Trieste University Hospital (ASUGI), Trieste 34125, Italy
Maurizio Ruscio, Division of Laboratory Medicine, Trieste University Hospital (ASUGI), Trieste 34125, Italy
Author contributions: Zerbato V and Di Bella S conceived/organized the study and wrote the manuscript; Giuffrè M performed the statistics; Zerbato V, Jaracz AW, Gobbo Y, Luppino D and Valentini M collected samples and provided help with conduction of the study; Segat L, Koncan R and D'Agaro P performed the virologic analysis; Macor P, Crocé LS, Ruscio M and Luzzati R reviewed the manuscript.
Institutional review board statement: This study was conducted according to the declaration of Helsinki and approved by the Ethics Committee (Unique Regional Ethical Committee, Friuli Venezia-Giulia 16 April 2020), No. CEUR 2020-OS-072.
Clinical trial registration statement: This study did not involve clinical trials.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare no conflicts of interest.
Data sharing statement: All study participants provided written consent prior to study enrollment.
CONSORT 2010 statement: CONSORT not applicable.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Stefano Di Bella, MD, Doctor, Infectious Diseases Unit, Clinical Department of Medical, Surgical and Health Sciences, Trieste University, Trieste 34123, Italy. stefano932@gmail.com
Received: February 2, 2021
Peer-review started: February 7, 2021
First decision: February 27, 2021
Revised: March 12, 2021
Accepted: April 21, 2021
Article in press: April 21, 2021
Published online: June 14, 2021
Processing time: 125 Days and 17.7 Hours
Core Tip

Core Tip: In this prospective study of 51 hospitalized patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia, whether fecal calprotectin correlated with SARS-CoV-2 intestinal shedding was investigated. We found that high fecal calprotectin level is a common finding among hospitalized coronavirus disease 2019 (COVID-19) patients, especially those with SARS-CoV-2 fecal shedding. Obese COVID-19 patients showed high fecal viral shedding.