Review
Copyright ©The Author(s) 2021.
World J Gastroenterol. Apr 21, 2021; 27(15): 1531-1552
Published online Apr 21, 2021. doi: 10.3748/wjg.v27.i15.1531
Table 1 Implication of severe acute respiratory syndrome coronavirus 2 on patients with hepatic disorders
Hepatic disorders
Main findings of the study
Ref.
NAFLDNAFLD is associated with a higher risk of symptomatic, severe, and progressive COVID-19Hashemi et al[137], 2020
SARS-CoV-2 infection in patients with NAFLD required ICU admission and mechanical ventilation concomitant with increased NAFLD progression to NASHSachdeva et al[212], 2020
Liver cirrhosisPatients with liver cirrhosis and COVID-19 are related to worse clinical outcomes and a high mortality rate than patients with COVID-19 aloneKushner and Cafardi[139], 2020
SARS-CoV-2 co-infection augmented liver injury as evidenced by worsens decompensated clinical statusSarin et al[143], 2020
Cirrhotic patients with COVID-19 had a higher risk of mortality than COVID-19 patients alone, but they are equally mortality rate with cirrhosis patients without COVID-19Bajaj et al[144], 2021
HCCPatients with HCC consider a risk group, and HCC is positively related to deterioration symptoms and bad outcomes in COVID-19Zhang et al[213], 2020
Patients with cancer are more susceptible to infection and poorer prognosis of COVID-19Liang et al[147], 2020
Hepatitis BPatients infected with HBV tend to have a more severe form of COVID-19Chen et al[150], 2020
SARS-CoV-2 and HBV co-infection showed monocytopenia, lymphopenia, and thrombocytopenia, as well as metabolic disordersLiu et al[151], 2021
COVID-19 may induce HBV reactivation, but it rarely occursAldhaleei et al[152], 2020
Hepatitis CPatients infected with HBV or HCV showed a high risk of mortality and morbidity if co-morbid with COVID-19Mirzaie et al[155], 2020
Patient with hepatic c and COVID-19 has an undesirable clinical outcomeMostardeiro et al[156], 2020
HCV pre-existing was associated with high mortalityMangia et al[157], 2020