©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 21, 2021; 27(15): 1531-1552
Published online Apr 21, 2021. doi: 10.3748/wjg.v27.i15.1531
Published online Apr 21, 2021. doi: 10.3748/wjg.v27.i15.1531
Impact of cytokine storm and systemic inflammation on liver impairment patients infected by SARS-CoV-2: Prospective therapeutic challenges
Fares E M Ali, Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut 71524, Egypt
Zuhair M Mohammedsaleh, Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk 71491, Saudi Arabia
Mahmoud M Ali, Osama M Ghogar, Pre-graduated students, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut 71524, Egypt
Author contributions: Ali FEM designed and critical wrote the manuscript; Mohammedsaleh ZM performed the manuscript proof editing and revision; Ali MM and Ghogar OM collected data and drafting the manuscript.
Conflict-of-interest statement: No potential conflicts of interest and financial support for this work.
Corresponding author: Fares E M Ali, MSc, PhD, Lecturer, Research Scientist, Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Al-Azhar University Street, Assiut 71524, Egypt. faresali@azhar.edu.eg
Received: January 26, 2021
Peer-review started: January 27, 2021
First decision: February 10, 2021
Revised: February 17, 2021
Accepted: March 29, 2021
Article in press: March 29, 2021
Published online: April 21, 2021
Processing time: 77 Days and 9 Hours
Peer-review started: January 27, 2021
First decision: February 10, 2021
Revised: February 17, 2021
Accepted: March 29, 2021
Article in press: March 29, 2021
Published online: April 21, 2021
Processing time: 77 Days and 9 Hours
Core Tip
Core Tip: Implications of fast coronavirus disease 2019 (COVID-19) outbreak are huge annoying problems that affected countries' health and economies around the world. Patients associated with hepatic impairment are considered at a high-risk target for severe acute respiratory syndrome namely coronavirus 2 severity and mortality. A good understanding of virus machinery provides excellent ideas about how to combat this monster. We provide detailed information about the recent mechanisms of COVID-19 pathogenesis, implications on several hepatic disorders, and potential therapeutic strategies.