Meta-Analysis
Copyright ©The Author(s) 2020.
World J Gastroenterol. Feb 28, 2020; 26(8): 865-876
Published online Feb 28, 2020. doi: 10.3748/wjg.v26.i8.865
Table 1 Characteristics of the nine selected studies comparing type 2 diabetes mellitus resolution by laparoscopic sleeve gastrectomy and Roux-en-Y gastric bypass in this study
Ref.CountryStudy typeSample size
Key findings
LSGLRYGB
Du et al[1], 2017ChinaRandomized clinical trial1974Overall remission rate achieved with LRYGB and LSG was 75.9% at 1 yr and 56.4% at 3 yr
Safety profile, T2DM resolution and other morbid obesity-related comorbidities by both procedures are comparable
Garg et al[42], 2017IndiaRetrospective clinical4040The median duration of T2DM was higher in LRYGB than LSG (2.2 vs 1.8), respectively
Both LRYGB and LSG showed significant but similar improvement in T2DM remission
Park and Kim[43], 2015South KoreaRetrospective Cohort Study104236The study found comparable results with insignificant differences between LRYGB and LSG
Perrone et al[27], 2016ItalyProspective clinical trials162142LSG is more effective in obese men than in women for excess weight loss. However, there is no difference in terms of the remission of comorbidities
LRYGB showed similar findings in both genders for excess weight loss and comorbidity resolution, including T2DM
Perrone et al[44], 2017ItalyProspective clinical trial162142LRYGB showed better T2DM resolution rate in the short-term
Neither LRYGB nor LSG showed a significant difference in T2DM remission in the long-term
Praveenraj et al[14], 2016IndiaRetrospective clinical trial5432LRYGB showed better surgical outcomes than LSG in patients > 50 yr
LSG had shorter operative times and shorter hospital stays
Peterli et al[45], 2018FinlandThe SLEEVEPASS multicenter, randomized clinical trial120120Complete or partial remission of T2DM was reported in 37% after LSG and in 45% LRYGB. No significant difference in terms of T2DM resolution is reported between LRYGB and LSG
Wallenius et al[29], 2018SwedenProspective clinical trial1518There was a similar decrease in post-op fasting blood glucose in both the LRYGB and LSG groups
LRYGB and LSG showed similar outcomes in glycemic control, with insignificant differences in short- and mid-term follow-up
Yang et al[22], 2015ChinaRandomized clinical study2223LSG and LRYGB had comparable effects on T2DM remission in the Chinese study cohort with a BMI of 28-35 kg/m2