Ever-increasing diversity of drug-induced pancreatitis

Table 1 The earliest classification system of drug-induced pancreatitis, as proposed by Trivedi et al[16]

Class I	Class II	Class III
≥ 1 case documenting a positive re-challenge	With or without drug re-challenge	All drugs associated with drug induced pancreatitis
≥ 20 case reports	10-20 case reports	< 10 case reports

Table 2 The more recent classification system of drug-induced pancreatitis, proposed by Badalov et al[13]

	Minimum No. of case reports	Re-challenge required	Latency established	Alternative causes of pancreatitis excluded
Class Ia	1	Yes	N/A	Yes
Class Ib	1	Yes	N/A	No
Class II	4	No	Yes1	N/A
Class III	2	No	No	N/A
Class IV	1	No	No	N/A

¹In greater than 75% of cases. N/A: Not applicable.

Table 3 Classes of medications implicated in drug-induced pancreatitis grouped according to the three-class system of classification

Class I	Class II	Class III
Aminosalicylates	Alkylating antineoplastics	Aminosalicylates
Anticonvulsants	Angiotensin-converting enzyme inhibitors	Antacids
Antimetabolite antineoplastics	Anticonvulsants	Antiarrhythmics
Antimicrobials	Antimicrobials	Antibacterials
Hormone replacement therapies	Antitubercular agents	Anticholinesterases
Loop diuretics	Interferons	Anticonvulsants
Non-biologic immunosuppressives	Nonopioid analgesics	Antidepressants
Nonsteroidal anti-inflammatories	Reverse transcriptase inhibitors	Antifungals
Opiates	Somatostatin analogs	Antihypertensives
Reverse transcriptase inhibitors	Thiazides	Antimetabolite antineoplastics
Steroids		Antineoplastics
		Antiplatelets
		Antivirals
		Atypical antipsychotics
		Cholesterol lowering agents
		Cyclooxygenase II inhibitors
		Estrogens
		Immunomodulators
		Nonsteroidal anti-inflammatories
		Parasympathetic agents
		Proton pump inhibitors
		Selective serotonin agonists
		Somatostatin analogs
		Steroids
		TNF-alpha inhibitors
		Vitamins