Mitochondrial metabolomic profiling for elucidating the alleviating potential of Polygonatum kingianum against high-fat diet-induced nonalcoholic fatty liver disease

doi:10.3748/wjg.v25.i43.6404

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Nov 21, 2019; 25(43): 6404-6415
Published online Nov 21, 2019. doi: 10.3748/wjg.v25.i43.6404

Table 1 Potential biomarkers identified from mitochondrial samples

Retention time, min	Molecular weight, Da	VIP	Potential biomarker	Formula	Change trend
Retention time, min	Molecular weight, Da	VIP	Potential biomarker	Formula	Model-PKRP
ESI-
15.0667	338.208	1.57637	PGJ2	C₂₀H₃₀O₄	Up
5.52016	203.082	1.39807	Ascorbate-2-sulfate	C₆H₈O₉S	Down
2.09975	267.074	1.36283	Allopurinol-1-ribonucleoside	C₁₀H₁₂N₄O₅	Down
1.78773	298.069	1.33035	D-4'-Phosphopantothenate	C₉H₁₈NO₈P	Up
15.384	293.18	1.24297	Sodium tetradecyl sulfate	C₁₄H₃₀O₄S	Up
20.3338	383.189	1.19012	Bortezomib	C₁₉H₂₅BN₄O₄	Up
3.96113	254.08	1.14379	Pantothenic acid	C₉H₁₇NO₅	Up
6.51405	455.097	1.11557	Flavin mononucleotide	C₁₇H₂₁N₄O₉P	Up
ESI+
7.0308	301.208	1.53312	Pinolenic acid	C₁₈H₃₀O₂	Up
1.09652	266.124	1.44566	N6-Methyl-2'-deoxyadenosine	C₁₁H₁₅N₅O₃	Up

VIP: Variable importance in the projection; ESI: Electrospray ionization.

Table 2 Results of metabolic pathway analysis in mitochondrial samples

No	Pathway	Match status	P-value	Impact	Details
1	Riboflavin metabolism	1/11	0.031049	0.33333	KEGG

KEGG: Kyoto Encyclopedia of Genes and Genomes.

Citation: Yang XX, Wei JD, Mu JK, Liu X, Li FJ, Li YQ, Gu W, Li JP, Yu J. Mitochondrial metabolomic profiling for elucidating the alleviating potential of Polygonatum kingianum against high-fat diet-induced nonalcoholic fatty liver disease. World J Gastroenterol 2019; 25(43): 6404-6415
URL: https://www.wjgnet.com/1007-9327/full/v25/i43/6404.htm
DOI: https://dx.doi.org/10.3748/wjg.v25.i43.6404