Copyright
©The Author(s) 2019.
World J Gastroenterol. Aug 21, 2019; 25(31): 4452-4467
Published online Aug 21, 2019. doi: 10.3748/wjg.v25.i31.4452
Published online Aug 21, 2019. doi: 10.3748/wjg.v25.i31.4452
Table 1 Relationship between APChigh and clinical characteristic and known prognostic genes
| Characteristic | APChigh | APClow | P-value |
| Age | 66 ± 8 | 61 ± 9 | 0.084 |
| Stage | |||
| I | 5 | 25 | 0.031 |
| II | 10 | 12 | 1 |
| III + IV | 29 | 7 | 0.043 |
| Grade | |||
| 1 | 4 | 33 | 0.031 |
| 2 | 15 | 5 | 0.047 |
| 3 | 25 | 6 | 0.039 |
| Lymph node metastasis | |||
| N0 | 7 | 23 | 0.027 |
| N1 | 10 | 12 | 1 |
| N2 | 11 | 4 | 0.031 |
| N3 | 16 | 5 | 0.035 |
| Distant metastasis | |||
| M0 | 7 | 9 | 0.781 |
| M1 | 37 | 35 | 0.812 |
| Gene | |||
| KIT | 29 | 15 | 0.031 |
| PIK3CA | 32 | 12 | <0.001 |
| KRAS | 28 | 16 | 0.038 |
| MLH1 | 28 | 16 | 0.038 |
Table 2 Association between differential mRNAs and APChigh
| mRNA | P-value (t-test) | P-value (Wilcoxon test) | Fold change | Regulation |
| BTAF1 | 1.45E-08 | 4.81E-10 | 2.00561 | Up-regulation |
| ARID5B | 1.20E-06 | 1.30E-07 | 2.011267 | Up-regulation |
| ZNF81 | 2.04E-06 | 3.84E-09 | 2.175277 | Up-regulation |
| JMY | 1.60E-09 | 4.99E-11 | 2.094035 | Up-regulation |
| MAP3K14 | 7.83E-07 | 3.00E-07 | 2.092268 | Up-regulation |
| PDE4D | 5.58E-07 | 4.33E-08 | 2.151154 | Up-regulation |
| CRYBG3 | 4.92E-07 | 1.10E-07 | 2.242404 | Up-regulation |
| PARD3B | 2.59E-06 | 9.38E-08 | 2.007173 | Up-regulation |
| PPARGC1B | 1.76E-08 | 2.04E-09 | 2.576507 | Up-regulation |
| TRANK1 | 6.01E-07 | 1.15E-08 | 2.165217 | Up-regulation |
| REV3L | 6.32E-07 | 1.14E-09 | 2.13368 | Up-regulation |
| IL6ST | 3.07E-07 | 1.30E-07 | 2.168223 | Up-regulation |
Table 3 APChigh associated KEGG pathways
| MSigDB | Size | ES | NES | P-value | Group |
| Kegg_b_cell_receptor_signaling_pathway | 74 | 0.579 | 1.712 | 0.012 | High |
| Kegg_pancreatic_cancer | 70 | 0.472 | 1.597 | 0.025 | High |
| KEGG_PROSTATE_CANCER | 89 | 0.450 | 1.570 | 0.025 | High |
| Kegg_prostate_cancer | 211 | 0.396 | 1.541 | 0.032 | High |
| Kegg_neurotrophin_signaling_pathway | 126 | 0.437 | 1.533 | 0.046 | High |
| Kegg_progesterone_mediated_oocyte_maturation | 85 | 0.412 | 1.491 | 0.040 | High |
| Kegg_ascorbate_and_aldarate_metabolism | 25 | -0.674 | -1.851 | 0.002 | Low |
| Kegg ppar_signaling_pathway | 69 | -0.456 | -1.621 | 0.003 | Low |
| Kegg_drug_metabolism_other_enzymes | 51 | -0.590 | -1.789 | 0.003 | Low |
| Kegg_steroid_hormone_biosynthesis | 55 | -0.595 | -1.853 | 0.004 | Low |
| Kegg_porphyrin_and_chlorophyll_metabolism | 41 | -0.617 | -1.833 | 0.004 | Low |
| Kegg_drug_metabolism_cytochrome_p450 | 70 | -0.569 | -1.776 | 0.012 | Low |
| Kegg_retinol_metabolism | 63 | -0.556 | -1.687 | 0.012 | Low |
| Kegg_metabolism_of_xenobiotics_by_cytochrome_p450 | 68 | -0.572 | -1.782 | 0.014 | Low |
| Kegg_pentose_and_glucuronate_interconversions | 27 | -0.638 | -1.734 | 0.016 | Low |
| Kegg_linoleic_acid_metabolism | 29 | -0.589 | -1.691 | 0.019 | Low |
| Kegg_alpha_linolenic_acid_metabolism | 19 | -0.565 | -1.662 | 0.020 | Low |
| Kegg_arachidonic_acid_metabolism | 58 | -0.424 | -1.541 | 0.031 | Low |
- Citation: Du WB, Lin CH, Chen WB. High expression of APC is an unfavorable prognostic biomarker in T4 gastric cancer patients. World J Gastroenterol 2019; 25(31): 4452-4467
- URL: https://www.wjgnet.com/1007-9327/full/v25/i31/4452.htm
- DOI: https://dx.doi.org/10.3748/wjg.v25.i31.4452